ID A0A1J9R8T8_9EURO Unreviewed; 816 AA.
AC A0A1J9R8T8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN ORFNames=ACJ73_03711 {ECO:0000313|EMBL:OJD24919.1};
OS Blastomyces percursus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=1658174 {ECO:0000313|EMBL:OJD24919.1, ECO:0000313|Proteomes:UP000242791};
RN [1] {ECO:0000313|EMBL:OJD24919.1, ECO:0000313|Proteomes:UP000242791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EI222 {ECO:0000313|EMBL:OJD24919.1,
RC ECO:0000313|Proteomes:UP000242791};
RA Cuomo C.A., Schwartz I.S., Kenyon C., De Hoog G.S., Govender N.P.,
RA Botha A., Moreno L., De Vries M., Munoz J.F., Stielow J.B.;
RT "Emmonsia species relationships and genome sequence.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:57924; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000426};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC ChEBI:CHEBI:58315; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001038};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJD24919.1}.
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DR EMBL; LGTZ01000464; OJD24919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J9R8T8; -.
DR STRING; 1658174.A0A1J9R8T8; -.
DR VEuPathDB; FungiDB:ACJ73_03711; -.
DR OrthoDB; 1908494at2759; -.
DR Proteomes; UP000242791; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.310.20; -; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR001079; Galectin_CRD.
DR InterPro; IPR041640; Tyrosinase_C.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR Pfam; PF18132; Tyosinase_C; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS51304; GALECTIN; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242791}.
FT DOMAIN 656..807
FT /note="Galectin"
FT /evidence="ECO:0000259|PROSITE:PS51304"
FT REGION 638..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 92517 MW; 379F3FAB1BCD3AC9 CRC64;
MAGTNYKPPE YLSKRPYEYY AITGIKAGTV PEQKKAPIRQ EIDEWSNNKE NSDQVDLFVM
AWRNLMNMSP RERGSFFQVA GIHGQPYVPY DEPDTNMEDT KDKGYCTHNN ILFPIWHRPY
LVLLEQLLYE NMITDIIPKF PKDRQTELKE AADSWRLPFW DWAINHRVPT LAKYPTTTIP
TPNGKRERVD NPLYQFKMST NEPFLSEGVG QVFDPWAGED GKGMYFNFGP CIGTSRSPDI
EDSQNPESET WKHGVVNNNQ VGIALKSPGW MGGGKYGAAS EMVYRLLTHP LDYPSFATTF
RAKGQDDISK DINLEYIHNN IHGWVGGNFT GHMSEIPVAT FDPLFWLHHC NIDRMWAIWQ
ALNPDKWFET ADKNTFFQEA IGLADTITPQ TKLRPFHSDK KGTCWTPEGA RDVLNFGYTY
PELQAWDSKY NSGGTYNREL HVTDIRKTIN EKYGASRTEL LENPTLGDKT DDGVKSNDFA
FSVRYKKYAL GGNPFNIKIY LAPGDGKPRT PESDYVTEVY NFSFPAIIGG KEVCSNCTSV
EATESKATSY LSITYVLVQC VKRGILASLE EAVVTKFLQK NLYWRVYQRG RELDRFAMEK
IELEVLGSFN NAQHHKDTTI LSGFEGFRDI PSLAGGPDGA LDPKLKQKSK PPPTNPPAPP
SAGLHKNSSL DLKVDFTTDG VIILDSTSVD LNQIQTDTID NTQVAFNNGS DTLFLISFRR
AEGQIVFNTN FGGKWGAEER VSLAGRLKNR QAAIMVHDQG EGFELSIDFV HVAWFKKRDK
RPIKRLRYSV NKNQKPVLSD ALKVSVYPSM QKVFSR
//
