ID A0A1K1MCR9_SELRU Unreviewed; 583 AA.
AC A0A1K1MCR9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
GN ORFNames=SAMN02910323_0747 {ECO:0000313|EMBL:SFW20909.1};
OS Selenomonas ruminantium.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Selenomonas.
OX NCBI_TaxID=971 {ECO:0000313|EMBL:SFW20909.1, ECO:0000313|Proteomes:UP000182958};
RN [1] {ECO:0000313|Proteomes:UP000182958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C3 {ECO:0000313|Proteomes:UP000182958};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FPJA01000004; SFW20909.1; -; Genomic_DNA.
DR RefSeq; WP_072305592.1; NZ_FPJA01000004.1.
DR AlphaFoldDB; A0A1K1MCR9; -.
DR Proteomes; UP000182958; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF01554; MatE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000182958};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 456..566
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF13581"
SQ SEQUENCE 583 AA; 63623 MW; B8C98B6429850C06 CRC64;
MERNGVLVQQ KYMEYLGSTM GFIVSLYLAS IVDGILVSQL ISPAAFAAIN LTLPVYYARN
ILFFLFVDGG AVLAAQFIGA RDKVSCARVF TISIAWGAAA MTLLGIIGCL LLSPTASLLA
GNSSLQEAVA DYLLPLWLTG PLLILTNGVS SFLRLEGLHK LAIAIPVVAN ICNLAFDYLF
IAVFGWGIAG AGWATGAGYV CSLLLLLPYL RRPDRSWHLT AIPADNQRIF RRVMAVGLPM
AMIPLGLVLR NLAVNGIAVE TLGDMGALTV SLCNAALLYA LMFADGSSTA LASVCGALYG
EMDQKGVLQV LKRSLRLTFG LCLLIFLLIF IFPAEFIRFY GVENITPELI LYLRTSIIYM
LLLAHVFILR AFYQATRQEK AATIFSLLEG VVLVIGLFFL LSKFSLVLMW AAPAISAVAA
IGWLVWYMRR QARKMGRDSF LLMQQEKNSA VWETSIPATV EAATEAAEAV DEFCARFADL
DSRQSYAAQV TVEELCVNIA EHGGLGTDGH IDVFLRLQEQ PVSEIVVKVR DGGKPFNPVH
FLDEQGEEFS GLLMVRKLTT KIEYARILGF NTAIVTIGKR GPK
//
