ID A0A1K1N691_9PROT Unreviewed; 1044 AA.
AC A0A1K1N691;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=SAMN05216414_11461 {ECO:0000313|EMBL:SFW30868.1};
OS Nitrosovibrio sp. Nv17.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosovibrio.
OX NCBI_TaxID=1855339 {ECO:0000313|EMBL:SFW30868.1, ECO:0000313|Proteomes:UP000183249};
RN [1] {ECO:0000313|EMBL:SFW30868.1, ECO:0000313|Proteomes:UP000183249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nv17 {ECO:0000313|EMBL:SFW30868.1,
RC ECO:0000313|Proteomes:UP000183249};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
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DR EMBL; FPIQ01000014; SFW30868.1; -; Genomic_DNA.
DR RefSeq; WP_072294237.1; NZ_FPIQ01000014.1.
DR AlphaFoldDB; A0A1K1N691; -.
DR OrthoDB; 9176627at2; -.
DR Proteomes; UP000183249; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF11; EFFLUX PUMP MEMBRANE TRANSPORTER; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000183249};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..496
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 548..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 878..898
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 905..925
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 931..954
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 975..996
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1008..1034
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1044 AA; 112701 MW; 30DFE1931BAF1E5F CRC64;
MDFSKFFIDR PIFAIVLSIV IFALGLIAIP LLPAGEYPEV VPPSVVVRAM YPGANPKEMA
DSIAVPLEEA INAVEGIMYM KSVAGSDGSL QVTVTFTPGI DPDTAAVRVQ NRVAQALSRL
PPDVRQYGVT TQKQSPTPLM FVSLSSPDNR YDGVYLRNYL TLNVKDKLSR LVGVGNVGLY
GEGDYAMRLW LNPNKLATRG LTAGDVVNAV REQNVQVSAG QLGAEPSPRS TDFLVPINVR
GRLRSEQEFG DIVLKSGDHG QLVRLSDVGR VELGSGDYTL HAMLNDKNGA SAGIFLTPNA
NSLAVARAVY AKFEELSANF PAGMTYRIVW DPTVFVRDSI RAVGQTLIEA VFLVVLVVIL
FLQTWRASII PLIAVPVSIV GTFAWLYLLG YSINTLTLFG LVLAVGIVVD DAIVVVENVE
RNIEAGLDPL AAAHQAMKEV SGPIVAIALV LCAVFVPMAF LSGVTGEFYK QFAVTIAIST
IISTINSLTL SPALAAKLLR RHDAPKDALT RLLERMLGWL FRPFNRLFLR SSGRYQGAVA
RTLGRRGIVF TVYAGLLLGT ATLFHVVPSG FIPNQDKLYL FAGAKLPEGA SLARTDAVTR
QLNGIARTIE GVDITESYVG MNALQSVNTP NQATSYVILK PFDQRQRSAE SIIAELNARL
VEIKDGQAYA LLPPPIQGLG NGSGYSLYLV DRAGLGYGAL QEALTAFQSA IAQTPGMTFP
VSSYQANIPQ LEVKVDRVKA MAQGVFLTDL FNTLQIYLGS IYVNDFNLFG RVYRVMAQAD
SAFRQKPEDI GNLYTRNAQG EMVPLGSMVT VQPAFGPDPV IRYNGYPAAD LIGDADPRVF
SSGQVITRLS EIAAEVLPRG ITLEWTDLSY QQVTQGNAAV IVFPLSILLV FLVLAALYES
WTLPLAVILI VPVCMCAALF GIWLAGGDNN IFVQVGLVVL MGLACKNAIL IVEFARELEI
QGKGTIDAAL EACRLRLRPI IMTSIAFIAG SIPLVLSHGA GSEVRHATGI TVFAGMLGVT
LFGLFLTPVF YVALRKLARL KPHG
//
