ID A0A1K1NFL5_9FLAO Unreviewed; 1126 AA.
AC A0A1K1NFL5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN02927921_01254 {ECO:0000313|EMBL:SFW34240.1};
OS Sinomicrobium oceani.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Sinomicrobium.
OX NCBI_TaxID=1150368 {ECO:0000313|EMBL:SFW34240.1, ECO:0000313|Proteomes:UP000182248};
RN [1] {ECO:0000313|EMBL:SFW34240.1, ECO:0000313|Proteomes:UP000182248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12145 {ECO:0000313|EMBL:SFW34240.1,
RC ECO:0000313|Proteomes:UP000182248};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FPJE01000005; SFW34240.1; -; Genomic_DNA.
DR RefSeq; WP_072316497.1; NZ_FPJE01000005.1.
DR AlphaFoldDB; A0A1K1NFL5; -.
DR STRING; 1150368.SAMN02927921_01254; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000182248; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SFW34240.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000182248}.
FT DOMAIN 572..733
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 742..908
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1126 AA; 129080 MW; B575A4B29BB30310 CRC64;
MGTEQSPQTR KLQDAIARIQ PPQRIYLNGL IGSSLSFVIA DSFKNNDLPY LLILNDKEEA
AYYLNDLEQL IGEEHVLFYP GSYRRPYQIE ETDNANVLLR AEVLNRLNSR KKPALIVTYP
DALFEKVVTR KELEKNTLKM KVGETIAPDF INEVLFEYRF KRVDFVSEPG EFSVRGGIID
VFSFSNDEPY RIEFFGDEVD SIRTFDVETQ LSVHKLNKIT IIPNVENKVR NESREGFLEY
ISPKTVVFFQ SYEILSSRID SLFRKAEEAF ASLSTETKHA SPHELFCTPK HIHEQLSRLV
VAETGNQSGI AFRHKAKEKH GEIITFRTRP QPSFNKQFDL LIEDLDRNRA DGYTNYIFCV
SEQQAKRFHD IFEEIEGEVY YKTIVFPIYQ GFIDDDRKMV CYTDHQIFER YHKFHLKNGY
AKKQAITLKE LTQLEIGDYV THIDHGIGKF GGLQKIQVEG KLQEAIKLVY GDGDILYVSI
HSLHKITKYN GKDGKPPKIF KLGSSAWKNL KKKTKSRVKE IAFSLINLYA KRRTEKGYSY
APDSYLQHEL EASFIYEDTP DQSKATQDVK NDMESEHPMD RLVCGDVGFG KTEVAIRAAF
KAVDNSKQVA ILVPTTILAF QHYKTFSERL KDLPVTVDYL NRFRTAREKR DILEKLGTGQ
IDIIIGTHQL VNKNVQFKDL GLLIVDEEQK FGVAAKEKLK NLKENVDVLT LTATPIPRTL
QFSLMAARDL SVITTPPPNR YPIESHVIQF NEEIIRDAVS YEIQRGGQVF FIHNRIENIK
EVAGMIQRLV PDAKVGIGHG QMEGKKLEQL MLGFMNGEFD VLISTTIIES GLDVPNANTI
FINNANNFGL SDLHQMRGRV GRSNKKAFCY FITPPYSAMT EDARKRIQAL EQFTELGSGF
NIAMKDLEIR GAGDLLGGEQ SGFINDIGFD TYQKILSEAI EELKENEFKD LYPQDEETRE
YVKDTQIDTD FELLFPDEYV NNITERLNLY NRLSTITTEE ELEKYETDLI DRFGPLPRQV
KDLLNSVRIK WIASEAGLEK VVLKHGKMVG YFIADQQSSF YQSKTFNRVI RTVQQNPALC
KMKEKNTRLG GLRLLLTFDH ITSVNKALKA LSPFVVKEAA HSETGY
//
