ID   A0A1K1QH46_9BACL        Unreviewed;       675 AA.
AC   A0A1K1QH46;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN02799630_04666 {ECO:0000313|EMBL:SFW59280.1};
OS   Paenibacillus sp. UNCCL117.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1502764 {ECO:0000313|EMBL:SFW59280.1, ECO:0000313|Proteomes:UP000182480};
RN   [1] {ECO:0000313|EMBL:SFW59280.1, ECO:0000313|Proteomes:UP000182480}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UNCCL117 {ECO:0000313|EMBL:SFW59280.1,
RC   ECO:0000313|Proteomes:UP000182480};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FPIU01000020; SFW59280.1; -; Genomic_DNA.
DR   RefSeq; WP_072335561.1; NZ_FPIU01000020.1.
DR   AlphaFoldDB; A0A1K1QH46; -.
DR   STRING; 1502764.SAMN02799630_04666; -.
DR   OrthoDB; 9814572at2; -.
DR   Proteomes; UP000182480; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182480};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          13..141
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          155..470
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   COILED          41..68
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   675 AA;  76614 MW;  0EEC09914CC8470D CRC64;
     MTEFAGSAAS QADFIWKNAE DLWGDFKHTD FGKIILPFTL LRRLECALES TRDAVREAYD
     NFKDAEIELD PILRQTAGYP FYNTSEYSLS TLGSTKTRRN LEDYIAQFSD NARAIFEEFE
     FGNTIIRLEK AGLLYTICKN FAGIDLHPDT VPDRVMSNIY EHLIRRFGAE VNEGAEDFMT
     PRDIVHLATA LLLDPDDALF EENPGLIRTL YDPTCGTGGF LTDAMNHVAD YGSHYKIPPV
     LVPHGQELEP ETHAVCVAGM LIRRLESDPG RDLSKNILQG STLSNDKFAG ERFHYCLSNP
     PFGKRWEKDK TAVEKEHKQG DLGRFGPGLP KISDGSMLFL MHLASKLELP QNGGGRAAIV
     LSGSPMFNGG AGSGESEIRR WLLENDLVEA IIALPTDIFF RTNIATYLWI LSNKKTEHRK
     DKVQLINATS LWTPIKNEGN KRRIVSDDQR RQILDIYSAA ENDKFSKMID YRVFGYRRIK
     VLRPLRMKLL LDEQGLSRLE SSDVWKKLTP AHQDFWLAAI KPVKGETKDY NWAETFVKEA
     VKSDEAKYIK VKANKTFIAE LLSTFGHKDP QAEPVLDAQG NMVPDTDLTD YENVPYLESI
     QDYFAREVLP HVPDAYIDES FTDDKDKLLG RVGYEINFNR FFYQYQPPRK LDDIDAELKQ
     VEGEIAALLA EVATE
//