ID A0A1K1U0S6_9GAMM Unreviewed; 301 AA.
AC A0A1K1U0S6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:SFX06037.1};
GN ORFNames=SAMN02745752_00383 {ECO:0000313|EMBL:SFX06037.1};
OS Marinospirillum alkaliphilum DSM 21637.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinospirillum.
OX NCBI_TaxID=1122209 {ECO:0000313|EMBL:SFX06037.1, ECO:0000313|Proteomes:UP000182350};
RN [1] {ECO:0000313|EMBL:SFX06037.1, ECO:0000313|Proteomes:UP000182350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21637 {ECO:0000313|EMBL:SFX06037.1,
RC ECO:0000313|Proteomes:UP000182350};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FPJW01000001; SFX06037.1; -; Genomic_DNA.
DR RefSeq; WP_072324610.1; NZ_FPJW01000001.1.
DR AlphaFoldDB; A0A1K1U0S6; -.
DR STRING; 1122209.SAMN02745752_00383; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000182350; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000182350}.
FT DOMAIN 6..167
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 170..289
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 176
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 301 AA; 32147 MW; 5E59E0328FD4BD89 CRC64;
MTSSRKLAFI GMGVMGAPMA SHLVKAGHQV TVYNRTFEKA QAWAERHPGQ QAARTPALAA
ADAEIVLLCV GNDADVREVI SGRNGLLESL KPGSLIIDHT TASASLAKEM VECCDQKQID
FLDAPVSGGQ QGAENGQLTI MVGGNNAAFV RGEPIMQCFA KAVTHMGPAG SGQLTKMVNQ
ICIGGLVQAL AEGLNFAAAA GLDQQKVIDV ISLGAAGSWQ MNNRHKTMIA NEYEHGFAVD
WMRKDLGICL EQARQINAQL PVTALVDQFY SEVQQLGGGR WDTSSLLRRL QAFSKPADNK
N
//
