ID A0A1K1YCH6_9GAMM Unreviewed; 404 AA.
AC A0A1K1YCH6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SFX59730.1};
GN ORFNames=SAMN02745752_02178 {ECO:0000313|EMBL:SFX59730.1};
OS Marinospirillum alkaliphilum DSM 21637.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinospirillum.
OX NCBI_TaxID=1122209 {ECO:0000313|EMBL:SFX59730.1, ECO:0000313|Proteomes:UP000182350};
RN [1] {ECO:0000313|EMBL:SFX59730.1, ECO:0000313|Proteomes:UP000182350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21637 {ECO:0000313|EMBL:SFX59730.1,
RC ECO:0000313|Proteomes:UP000182350};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; FPJW01000008; SFX59730.1; -; Genomic_DNA.
DR RefSeq; WP_072326491.1; NZ_FPJW01000008.1.
DR AlphaFoldDB; A0A1K1YCH6; -.
DR STRING; 1122209.SAMN02745752_02178; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000182350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000182350};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SFX59730.1}.
FT DOMAIN 3..263
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 384
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 404 AA; 42522 MW; EFC18762F60039C7 CRC64;
MSVYIYDAGR TPFGRHAGVL AGVRPDDLLG GLIAQLIKRN PFDLIDYEDV VAGCASQAGE
DARNVARHAA LLAGLPVQVG GLTVNRLCGS GLAAILDAAR AIRCEEGDLF LAGGVESMSR
APFVVGKADA AFSRKFEVFD SSIGARFPNP LIENQFGSDT MPETADNVAR QLGISRDDCD
AFALRSQIHY SQALAAGHFE SEVLAVQIQH KKKPPVLIEQ DEHPRPDTTL ESLSRLMPLY
EGGVVTPGNA SGINDGAAAV IMGNSSVGQR YDLRPRARLL AGAVAGVEPR FMGLGPVNAI
KKALLRAGLK LSDMDVIEIN EAFAAQVLGC TRSLGLADDD PRLNPKGGAI ALGHPLGASG
ARLVATALHF LEQTGGRFAL VSLCIGLGQG IACVLERCES HNKN
//
