ID A0A1K2FKX3_9ACTN Unreviewed; 311 AA.
AC A0A1K2FKX3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Thioredoxin reductase {ECO:0000313|EMBL:SFY47687.1};
DE EC=1.8.1.9 {ECO:0000313|EMBL:SFY47687.1};
GN Name=trxB_1 {ECO:0000313|EMBL:SFY47687.1};
GN ORFNames=STEPF1_00898 {ECO:0000313|EMBL:SFY47687.1};
OS Streptomyces sp. F-1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=463642 {ECO:0000313|EMBL:SFY47687.1, ECO:0000313|Proteomes:UP000095403};
RN [1] {ECO:0000313|EMBL:SFY47687.1, ECO:0000313|Proteomes:UP000095403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Streptomyces sp. F1 {ECO:0000313|EMBL:SFY47687.1};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000849};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; FKJI03000002; SFY47687.1; -; Genomic_DNA.
DR RefSeq; WP_070026528.1; NZ_FKJI03000002.1.
DR AlphaFoldDB; A0A1K2FKX3; -.
DR OrthoDB; 9786503at2; -.
DR Proteomes; UP000095403; Unassembled WGS sequence.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase (NADP) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR PANTHER; PTHR48105:SF28; THIOREDOXIN REDUCTASE GLIT (AFU_ORTHOLOGUE AFUA_6G09740); 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:SFY47687.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095403}.
FT DOMAIN 6..281
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 311 AA; 33135 MW; 563FD358EC901874 CRC64;
MDTQLYDTVI VGGGPAGLNG ALYLGRSRRR VLLVDSGDAR NMAAGVMHNV LTNDGAAIAD
FRARARAQLA SYDVTFRDDE VVSAESGGDH VVVTAKESGT VRARTLLYAA GVRSVLPPVP
GLAPLWGKAV FECPYCHAWE VRERRFAVYG GGVPSECLAS TLTVWSDDIT YLAGGRALPA
DEQDRLAAAK VPVLTEGVRE LRPHPEGLEV VFADGRTASY GAMFLHLDIE PRVAPLRPWL
TAPDLESVQT DDRGRTSLPR LYVAGDLGRN MQQAAMAAAS GGLAAMAINA DLIREDRPGS
LPEPPPPAPA R
//