ID A0A1K2FR90_9ACTN Unreviewed; 786 AA.
AC A0A1K2FR90;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Helicase IV {ECO:0000313|EMBL:SFY50273.1};
DE EC=3.6.4.12 {ECO:0000313|EMBL:SFY50273.1};
GN Name=helD_4 {ECO:0000313|EMBL:SFY50273.1};
GN ORFNames=STEPF1_03521 {ECO:0000313|EMBL:SFY50273.1};
OS Streptomyces sp. F-1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=463642 {ECO:0000313|EMBL:SFY50273.1, ECO:0000313|Proteomes:UP000095403};
RN [1] {ECO:0000313|EMBL:SFY50273.1, ECO:0000313|Proteomes:UP000095403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Streptomyces sp. F1 {ECO:0000313|EMBL:SFY50273.1};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FKJI03000008; SFY50273.1; -; Genomic_DNA.
DR RefSeq; WP_070022701.1; NZ_FKJI03000008.1.
DR AlphaFoldDB; A0A1K2FR90; -.
DR OrthoDB; 9787585at2; -.
DR Proteomes; UP000095403; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000095403}.
FT DOMAIN 230..637
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 251..258
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 786 AA; 85942 MW; 0747756389FDFBED CRC64;
MAAQVQHSAV GSVQDAHDSA RDREISVEQA HLDRVYRRLE EKIHEAEFLM NDAAKRGQVG
TPGALAERDA QVFRAGIHLN RLNNEFEDFL FGRIDLLLGK DGKKGPDGAY TAVEPAEGAV
REDNTADIAE TLHIGRIGVL DAEYAPLVID WRAPAAAPFY RATPVEPGRV VRRRVIRSKG
RRVLGVEDDL MRPELTARLD GRELAVIGDG ALMAALGQAR GHTMRDIVSS IQAEQDLVIR
APAASITYVE GGPGTGKTAV ALHRAAYLLY QDRRRYAGGI LIVSPTPLLV AYTEGVLPSL
GEEGQVAIRA IGSLVDGAEA TLYDSPSVAR AKGSHRMLKV LRKAARGALE LGPAACAGHE
DDDTEGPRAL DGTPTRLRVV AFGRRLELEA EELDRIRRTA LGGTAPVNLL RPRARKLLLD
ALWEKSGAGT RHTDPELAAE LRSSFDEDIT TEDAFIGFLD AWWPELTPAR VLDAMADEKR
LGRWARRILN PGEVRKVARS LKRDGHSVHD IALLDELQAI LGVPARPRRK RELDPLDQLT
GLEELMPVRE ESQRERAERL AQERTEYAHV IVDEAQDLTP MQWRMIGRRG RHATWTVVGD
PAQSSWSDPD EAAEARDEAL GSRPRRRFRL TVNYRNPAEI AELAARVLAL AMPGSESPTA
VRSTGVEPRF TVVGESLEAT VRAEAERLLG LVDGTVGVVV AMNRREEARR WLAGLGDRVV
ALGSLEAKGL EYDATVVVSP AEIADESPAG LRVLYVALTR ATQQLTVVSG ERDEPDAAGV
PDLLRD
//
