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Database: UniProt
Entry: A0A1K2G1Q9_9ACTN
LinkDB: A0A1K2G1Q9_9ACTN
Original site: A0A1K2G1Q9_9ACTN 
ID   A0A1K2G1Q9_9ACTN        Unreviewed;       429 AA.
AC   A0A1K2G1Q9;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   13-FEB-2019, entry version 13.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   Name=hom {ECO:0000313|EMBL:SFY53311.1};
GN   ORFNames=STEPF1_06592 {ECO:0000313|EMBL:SFY53311.1};
OS   Streptomyces sp. F-1.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=463642 {ECO:0000313|EMBL:SFY53311.1, ECO:0000313|Proteomes:UP000095403};
RN   [1] {ECO:0000313|EMBL:SFY53311.1, ECO:0000313|Proteomes:UP000095403}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Streptomyces sp. F1 {ECO:0000313|EMBL:SFY53311.1};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FKJI03000039; SFY53311.1; -; Genomic_DNA.
DR   RefSeq; WP_070027850.1; NZ_FKJI03000039.1.
DR   BioCyc; GCF_900079405:G1FMJ-5600-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000095403; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095403};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:SFY53311.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095403};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      352    425       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      11     18       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    206    206       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     106    106       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     191    191       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   429 AA;  44491 MW;  C92B6B1875F6A809 CRC64;
     MRTRPLKVAL LGCGVVGSEV ARIMTTHADD LAQRIGAPVE LAGVAVRRPS KVREGIDPAL
     VTTDATALVK RGDIDVVVEV IGGIEPARSL ITTAFEHGAS VVSANKALLA QDGAALHAAA
     EEHGRDLYYE AAVAGAIPLI RPLRESLAGD KVNRVLGIVN GTTNFILDKM DSTGAGYQEA
     LDEATALGYA EADPTADVEG FDAAAKAAIL AGIAFHTRVR LDDVYREGMT EVTAADFRSA
     KEMGCTIKLL AICERARDGA SVTARVHPAM IPLSHPLASV RGAYNAVFVE SDAAGQLMFY
     GPGAGGSPTA SAVLGDLVAV CRNKLNGTTG PGESAYAALP VSPMGDVVTR YHISLDVADK
     PGVLAQVATV FAEHGVSIDT VRQQGKDGEA SLVVVTHRAL DAALSGTVEA LRKLDTVRGV
     ASIMRVEGE
//
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