ID   A0A1K2IE19_9FLAO        Unreviewed;       913 AA.
AC   A0A1K2IE19;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=SAMN05428642_1011066 {ECO:0000313|EMBL:SFZ90661.1};
OS   Flaviramulus basaltis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flaviramulus.
OX   NCBI_TaxID=369401 {ECO:0000313|EMBL:SFZ90661.1, ECO:0000313|Proteomes:UP000182544};
RN   [1] {ECO:0000313|EMBL:SFZ90661.1, ECO:0000313|Proteomes:UP000182544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18180 {ECO:0000313|EMBL:SFZ90661.1,
RC   ECO:0000313|Proteomes:UP000182544};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FPKV01000001; SFZ90661.1; -; Genomic_DNA.
DR   RefSeq; WP_072400679.1; NZ_FPKV01000001.1.
DR   AlphaFoldDB; A0A1K2IE19; -.
DR   STRING; 369401.SAMN05428642_1011066; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000182544; Unassembled WGS sequence.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182544};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          578..771
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   913 AA;  104235 MW;  FC693BC118AAD2E2 CRC64;
     MDKFSFLNAA HTAYFADLYD QYLQNPDTVE PSWRAFFQGY DFGSENYGLN GEIVEGVSTQ
     IPEYVQKEFQ VVRLIDGYRM RGHLFTKTNP VRDRRTYSPT LELHNFDLSD SDLDTVFNAG
     EILGIGAQTL REIIKHLDSI YCSSIGVEYM YLRNPEVIKW WQDQLNKNDN QPNFSAETKK
     YILSKLNQAV TFENFLQTKY VGQKRFSLEG GESLIPAISN VLFYAVEKYG VKECVLGMAH
     RGRLSTLINI FRKPVRELFS EFDGKDFEDE DIDGDVKYHL GLTLDKTYQN GKNIKMNLVP
     NPSHLETVAP VAEGITRAKI DSDYDGDNSK IIPIIVHGDA AIAGQGVVYE VAQMSQLNGY
     KTGGTIHIVV NNQIGFTTNY LDARSSTYCT DVAKVTLSPV LHVNSDDAEA VVHAVEMALE
     YRMRYKKDVY IDLLGYRKYG HNEGDEPRFT QPKLYKEIAK HSNPFKIYSD KLIAEKTIDK
     AYSDKIVSDF KETLETEYEK AKKADSSIVR EFMQERWTGF ERQGLDAMLE TEDTTYAKNK
     LENISKVVST VPEGAKFLRK AERILEGRAK MVFETDTLDW GMAETLAYGS LMEEGFNIRI
     SGQDVERGTF SHRHAILRDE KSEERINLLN TNPENKGKMD IYNSFLSEYG VLGFDYGYAM
     ATPNTLTIWE AQFGDFSNGA QIIFDQYLSA AEDKWKAQNG IVVLLPHGYE GQGSEHSSAR
     IERYLQLCGN DNMIVADCTT PGNFYHLLRR QMKRDYRKPL IVFTPKSLLR HPKAVSSLEE
     LATGSFQEVI DDTINPKGVK KLVFCTGKFY YDLLAERDEL KTEDVALVRI EQLFPLHTQK
     IQDVINKYPN VEKYVWAQEE PKNMGAWSHI AQRLDLVKIE VCSRPYASVP APGSSTRDKR
     RQKRVINAVF DKE
//