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Database: UniProt
Entry: A0A1L0DKN7_9ASCO
LinkDB: A0A1L0DKN7_9ASCO
Original site: A0A1L0DKN7_9ASCO 
ID   A0A1L0DKN7_9ASCO        Unreviewed;       450 AA.
AC   A0A1L0DKN7;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=tRNA wybutosine-synthesizing protein 2 {ECO:0000256|PIRNR:PIRNR038972};
DE            Short=tRNA-yW-synthesizing protein 2 {ECO:0000256|PIRNR:PIRNR038972};
DE   AltName: Full=tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase {ECO:0000256|PIRNR:PIRNR038972};
GN   ORFNames=SAMEA4029010_CIC11G00000003711 {ECO:0000313|EMBL:SGZ56456.1};
OS   [Candida] intermedia.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC   Candida/Metschnikowiaceae.
OX   NCBI_TaxID=45354 {ECO:0000313|EMBL:SGZ56456.1, ECO:0000313|Proteomes:UP000182334};
RN   [1] {ECO:0000313|EMBL:SGZ56456.1, ECO:0000313|Proteomes:UP000182334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 141442 {ECO:0000313|EMBL:SGZ56456.1,
RC   ECO:0000313|Proteomes:UP000182334};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a
CC       component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
CC       modified guanosine with a tricyclic base found at the 3'-position
CC       adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes
CC       the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-
CC       adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14)
CC       to produce wybutosine-86. {ECO:0000256|PIRNR:PIRNR038972}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine =
CC         4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) +
CC         H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA-
CC         COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315,
CC         ChEBI:CHEBI:73550; EC=2.5.1.114;
CC         Evidence={ECO:0000256|ARBA:ARBA00036405};
CC   -!- PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004797, ECO:0000256|PIRNR:PIRNR038972}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR038972}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM5/TYW2 family. {ECO:0000256|PIRNR:PIRNR038972}.
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DR   EMBL; LT635760; SGZ56456.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1L0DKN7; -.
DR   STRING; 45354.A0A1L0DKN7; -.
DR   OrthoDB; 122704at2759; -.
DR   UniPathway; UPA00375; -.
DR   Proteomes; UP000182334; Chromosome v.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0031591; P:wybutosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR030382; MeTrfase_TRM5/TYW2.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR026274; tRNA_wybutosine_synth_prot_2.
DR   PANTHER; PTHR23245; TRNA METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR23245:SF25; TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG; 1.
DR   Pfam; PF02475; Met_10; 1.
DR   PIRSF; PIRSF038972; Trm12; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51684; SAM_MT_TRM5_TYW2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR038972};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182334};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR038972};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR038972};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694,
KW   ECO:0000256|PIRNR:PIRNR038972}.
FT   DOMAIN          168..444
FT                   /note="SAM-dependent methyltransferase TRM5/TYW2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51684"
SQ   SEQUENCE   450 AA;  51046 MW;  36698C24989A87E3 CRC64;
     MFGLRTFVSG HYTVQRSEVP YHPVKMPSKV GINNKHIIKS VKTLLEKHGI LDKSTKISSS
     DGYSYIYSVA PVEDVESILD EYSDEIVVKE YLVPSAARSI SRSLESVVRA YLEDARAAGV
     DVNVDLLMSK LPRKWSIYTP MVLFNTGGFD SEIWTEVFAS SINASSFFNV VRAAFPATIT
     HFAINKPIVE EDVMRRPFNL VALHGDFGPE TSEVLFELPK PDDLEDAFWC HVVQNGIYQT
     WAPRYTMFSR GNITEKKRVL DNFKNLKGLV VMDFYAGIGY FTLSYLANGG TLLCWELNPW
     SIEGLVKGLS ENGYKYQVFS NGEFLTKEDY DRHLAQGVRA FVFHESNENV VTRLQQLGRL
     PVSHINLGLL PSLQASWSTV KTVRDQWTSR DIVVHVHENE HKDRFEQLLS KIGDYFKGEV
     IHFEKVKTFA PDIWHVVVDI GIGGGKEKEN
//
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