ID A0A1L0G652_9ASCO Unreviewed; 641 AA.
AC A0A1L0G652;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=SAMEA4029010_CIC11G00000002665 {ECO:0000313|EMBL:SGZ52029.1};
OS [Candida] intermedia.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=45354 {ECO:0000313|EMBL:SGZ52029.1, ECO:0000313|Proteomes:UP000182334};
RN [1] {ECO:0000313|EMBL:SGZ52029.1, ECO:0000313|Proteomes:UP000182334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 141442 {ECO:0000313|EMBL:SGZ52029.1,
RC ECO:0000313|Proteomes:UP000182334};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; LT635758; SGZ52029.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L0G652; -.
DR STRING; 45354.A0A1L0G652; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000182334; Chromosome iii.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000182334}.
FT DOMAIN 18..217
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 322..574
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 93..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 71386 MW; 20CD6FDBB2C66750 CRC64;
MDGATKSWLI KKFGPSEDEV LTRLVTVQNL FNFSNEDIYI QWEAFVVTHE NGDADLSLVN
IEKFQQYLQD LLANNHQKRT PAVKKVRDLS NKRPIDFSSS PGVVLPSTPS LKRKKPILTS
EPDSSPSKKD VASSPIKAQS SNTVLETLNP DVEVDNIADN VQLTANFDPE KFKFRTMAMK
LLESADVLDD QIDMFSQQLL TEYKDKDIQL GNPCMSSQFD IVCCGRIVPD SPFYDSMIVQ
NLNDKSLFLE TSRLGGIGQR IPLDLSNLEE YSFFPGQVVG LRGRNPTGRA FVAHDVIALP
QLGTPVSSGS ELSEFSKEGS KILIAAGPFT NQHTLDYSRL EKLVDHVNTE VKPQAVLLFG
PFLDITNKAV ESGNVELPHT AANQQPKNLD ELFRAVVTPV LKKFDPSIQV VLLPSLKDSA
SKHASYPQSS LDRKRLGLPK NFKCFPNPSN FSINEIMVGA SNADVFKDLK DIYKSGVSPE
KSKLFSNRFE RIANHVFEQR RFYPVFPGSV KRVALPKEEG EKVTNLLDGM MGEELAETEV
GGSSLEVPYI GVTELSHSLP DVLIVPSELK YFAKVIKGVV VINPGQFIRP NKDPLREDGS
YVVMTTRGPD ANDENNIEPV EGSDLFYHNV FKRSRIDIMK T
//
