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Database: UniProt
Entry: A0A1L1RP70_CHICK
LinkDB: A0A1L1RP70_CHICK
Original site: A0A1L1RP70_CHICK 
ID   A0A1L1RP70_CHICK        Unreviewed;      4867 AA.
AC   A0A1L1RP70;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000060582};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSGALP00000060582};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000060582, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000060582, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000060582,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000060582}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000060582};
RG   Ensembl;
RL   Submitted (DEC-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AADN04000014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC147971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000085872; ENSGALP00000060582; ENSGALG00000009705.
DR   GeneTree; ENSGT00940000155507; -.
DR   OrthoDB; 5161at2759; -.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Proteomes; UP000000539; Chromosome 5.
DR   ExpressionAtlas; A0A1L1RP70; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4186   4206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4409   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4473   4495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4668   4689       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4748   4771       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    399       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1253   1467       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3929   3957       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      458    478       {ECO:0000256|SAM:Coils}.
FT   COILED     3222   3242       {ECO:0000256|SAM:Coils}.
FT   COILED     3589   3616       {ECO:0000256|SAM:Coils}.
FT   COILED     4332   4352       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4867 AA;  552324 MW;  B874218902680D54 CRC64;
     MAEGGEGGED EIQFLRTDDE VVLQCVSSIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICNFVL EQSLSVRALQ EMLTNTGDNA SEGAAQGGHR TLLYGHAILL RHSFSEMYLT
     CLTSSRSQTD KLAFDVGLRE NAAGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSMSNGSI QVDASFMQTL WNVHPTCSGS NITEGYLLGG HVVRFFHGHD ECLTIPSTDQ
     NDSQQKKVLY ETGGAGVRAR SLWRVEPLRI SWSGSNIRWG QPFRLRHITT GMYLALNDDE
     GLVMLDREKS DTTSSAFCFR ASKELKEKQD STLKRDIDGM GVPEIKYGDS VCFIQHVASA
     LWLTYKAPDA KSARLGLLKR KVILHQEGHM DDGLTLQRCQ HEESQAARII RNTTSLFSQF
     ISGNNRTLSP IALPVEEMAQ TLQDLIKYFQ PPGEDLEHED KQNKLRSLKN RQNLFKDEGM
     LALVLNCIDR LNDYNSAAHF AEISRVENGT AWKEILNLLY ELLAALIRGN RNNCTQFSSN
     LDWLISKLDR LESSSGILEV LHCILIESPE ALNVIAEEHI KSIISLLDKH GRNYKVLDVL
     CSLCVCNGVA VRANQNLICD NLLPRRDLLL QTRLINDVTS IRPNIFLGVA EGSAQYKKWY
     FELIIDQVDP FLTAEPTHLR VGWASTSGYA PYPGGGEGWG GNGVGDDLYS FGFDGLHLWS
     GRVPRAVASV NQHLLSSDDV VSCCLDLGVP SISFRINGQP VQGMFENFCT EGFFFPVVSL
     SAGVKARFLL GGRHGEFKFL PPTGYAPCYE ALLPKEKMKL EPVKEYKRDS DGVRDLLGTT
     QFLSQASFIP CPIDTSQIAL PFHLEKIRDK LAENIHELWG MNKIELGWTY GKIRDDNKRH
     HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIVHAN PAAEEDLKKV KLPKNYIMSN
     GYKPAPLDLS EVKLLPSQEF LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KNKRNPRLVP
     YALLDERTKK SNRDSLREAV RTFAGYGYNV EPPDQEIADQ TVEKVSIDKI RFFRVEQSYA
     VKSGKWYFEF EAVTGGDMRV GWARPGCRPD IELGADDQAF VFEGSKGQRW HQGSGFFGRS
     WQPGDVVGCM INLDDKSIIF TLNGELLITS KGSELAFADF GIESGFVPIC SLGLSQIGRM
     NLGMDASTFK YYTMCGLQEG FEPFAVNMNR DVAMWFSKRL PTFVNVPKNH PHIEIWRIDG
     TIESPPRLKV THKTFGTQNS NSDMIYCRLS MPIEFRSSFN FGVGVENASS DALQKRKHSQ
     EFPASSTTCF YSLRIFAGQD PSSVWVGWVT PDYHFYSENF DINKNCTVTV TLGDERGRVH
     ESVKRSNCYM VWGGDIAANS QRSGRSNVDL EIGCFVDLAT GMLSFTANGK ELGTCYQVEP
     NTKLFPAAFV QPTSTNLIQF ELGKLKNTMP LSAAIFKSEE RNPVPQCPPR LDVQTITPVL
     WSRMPNSFLK VETERVSERH GWVVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMKFHY
     HTLKLYSSVC ALGNTRVAYA LCSHVDISQL FYTIDNQYLP GLLRSGFYDL LISIHLDHAK
     QAKLMMNNEF IIPVTEETRT IKLYPDETKK HGLPGVGLST CLKPSFNFST PCFIVTSEEH
     QTSSPDIPLD TLKSKAISML TEAVQCSGSH IRDPVGGHIA FQFVPVLKLI ATLLVMGVFD
     DDDVKQVLIL IDPNVFGDHK EEAEEKTEKE EVTQVEEKAV EAGEKAVKET KAPTKGLLQT
     RLPESVKLQM CHLLNYFCDC ELQHRVEAIV SFADHYVSKL QYNQKYRYNE LMQALNMSAA
     LTAKKTKEFR SPPQEQINML LNFQLGEDCP CPEEIRDELY DFHDDLLIHC GIPLEEEEEE
     EEDSSLTGKL RSLIYKIKGP PKPEKIEPRE EEDKSPTTLK ELISQTMVRW SQEDQIQDPE
     LVRIMYTLLR RQYDSIGELL QALRKAYTIS AASVKDTINL LAALGQIRSL LSVRMGKEEE
     LLMINGLGDI MNNKVFYQHP NLMRVLGMHE TVMDVMVNVL GGDKSQIAFP KMVASCCRFL
     CYFCRISRQN QKAMFEHLSY LLENSSVGLA FPSMRGSTPL DVAAASVMDN NELALALEEP
     DLDKVVTYLA GCGLQSCPVL LAKGYPDIGW NPIEGERYLS FLRFAVFVNS ESVEENASVV
     VKLLIRRPEC FGPELRGEGG NGLLAAMQEA IRISENPTRD LPSQGYKREG DEEEEEEEEI
     VHMGNAIMSF YSALIDLLGR CAPEMHLIQS GKGEAIRIRS ILRSLVPTED LVGIISIPLK
     LSTVNKDGTV NEPDMSANFC PDHKAPMVLF LDRVYGIKDQ SFLLHLLEVG FLPDLRASAS
     LDTVSLSTTE AALALNRYIC SAVFPLLKRC APLFSGTEHH ASLVDSMLHT IYRLSKGRSL
     TKAQRDTIEE CLLAICHHLR PSMLQQLLRR LVFDVPLLNE YCKMPLKLLT NHYEQCWKYY
     CLPSGMGSYG IAAEDELHLT EKLFWGIFDS LSHKKYDPEL FRMALPCLSA IAGALPPDYL
     DTRIRSTLEK QTSVDPEGNF DPKPVNTANL VLPEKLEYIV SKYAEHSHDK WAFDKTNNGW
     KYGVSLDENT KTHPLIRPFK TLTEKEKEIY RWPVRESLKT MLAMGWSLER TKEGGEGMLH
     QRENEKLRSI SQSSQGNGYS PAPLDLTNVV LSRELQGMVE VMAENYHNIW AKKKKMELES
     KGGGSHPLLV PYDTLTAKEK SRDREKAQEL FKFLQVNGII ISRGLNDMDL DASSMEKRFA
     FKFLKKILKY VDSAQEFIAH LEAIVTSGKT EKSPHDQEIK FFAKVLLPLV DQYFTNHCLY
     FLSSPTKTLS SSGYASNKEK EMVASLFCKL AALVRHRISI FGSDSTTMVS CLHILAQSLD
     TRTVMKSGSE LVKAGLRAFF ENAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL
     LPVLTSIFEH ISQYHFGVDL LLGDVQVSCY RILCSLYSLG TGKNIYVERQ RPALGECLAS
     LAAAIPVAFL EPSLNHYNPL SVFNTKSARE RAILGMPDTV EEMCPEIPQL DGLIKEINNL
     AESGARYTEM PHVIEVILPM LCNYLSYWWE RGSESVPESA GPCCTMITSE HLSIILGNIL
     KIINNNLGID EASWMKRIAV YAQPIISKAR PDLLKTHFIP TLEKLKKKAI KIVMEEEQLR
     ADSKSDTQEA ELLILDEFAV LCRDLYAFYP MLIRYVDNNR ANWLKKPDAD SDELFRMVAE
     VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDTKSKMSK AMQVKSGGQD QERKKSKRRG
     DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKTRY SHRDTDEEVK EHIRNNLHLQ
     EKSDDPAVKW QLNLYKDILK SDEPPDPEKN VERVQRISAA LYHLDQVEQP LRSKKAVWHK
     LLSKQRKRAV VACFRMAPLY NLPRHRSINL FLHGYQNYWI ETEEYSFEEK LVQDLATSPK
     KEEEEEEDTE KEQPDPLHQI ILYFSRNALT ERSKLEDDPL YIAYAAMMAK SCQEEEEEEE
     EDKEKTFEEK EMEKQRTLYQ QARLHDRGAA EMVLQMISAS KGHTGPMVVE TLKLGIAILN
     GGNTIVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL GMVTEEGTLI
     VRERGEKVLQ HDEFTRDLFR FLQLLCEGHN NDFQNYLRTQ MGNTTTVNII ISTVDYLLRL
     QESISDFYWY YSGKDVIDES GQRNFSKALA VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW
     DAVVGFLHVF ANMQMKLSQD SAQIELLKEL LDLLKDMVVM LLSLLEGNVV NGTIGKQMVD
     TLVESSSNVE LILKFFDMFL KLKDLTNSDA FKEHDPDGKG IISKKDFQKS MEAQKQYIQS
     EIEFLLSCAE ADENDMFNYI DFVERFHEPA KDIGFNVAVL LTNLSEHMPN DSRLQSLLEP
     AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRMQWE KPQVKESKRQ FIFDVVNEGG
     EQEKMELFVN FCEDTIFEMQ LASQISESDS AERLRKEEEP CYVVDIGDDE EEEKSLESPS
     AFALACAAVK KNVANFFKMV TVKNLRKQYR KVRKMTVKEM VKCFSFFWIL FVGVFQLFFT
     IVWGIFQILW STVFGGGLVE GAKNIKVTKI LGDMPDPTQF GIHDDVTEAE KTEGAEHGIR
     DELVQFVKGE KGETDIISDI FGIPTKKEGG SKHGHDAGLG DIAEILGSDI QSSLENNARK
     KKGLQIPETA KEAEAERKVE AEKADMEDGE KQDKAKEEQS EQPEEGKMKK KKRRHGQKIE
     KPEAVMANFF KALEIYQTKI LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLDEVE
     EDSNLWNSFE EEEEEEGMVF FVLEESTGYM APALRALAVI HTIISFVCVI GYYCLKVPLV
     VFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLVINTP SFPNNYWDKF VKRKVINKYG
     DLYGAERIAE LLGLDKNALD FSPVEESEPE AASLVSWLSS IDTKYHIWKL GVVFTDNSFL
     YLAWYTTMSI LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL
     YTVVAFNFFR KFYNKSEDED EPDMKCDDMM TCYLFHMYVG VRAGGGIGDE IEDPAGDPYE
     MYRIVFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV REDMETKCFI CGIGNDYFDT
     IPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESFV WKMYQERCWD FFPAGDCFRK
     QYEDQLG
//
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