ID A0A1L1RSV3_CHICK Unreviewed; 445 AA.
AC A0A1L1RSV3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Beclin-1 {ECO:0000256|ARBA:ARBA00018490};
GN Name=BECN1 {ECO:0000313|Ensembl:ENSGALP00010032737.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010032737.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010032737.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010032737.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|ARBA:ARBA00004419}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004318}.
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR AlphaFoldDB; A0A1L1RSV3; -.
DR Ensembl; ENSGALT00010054228.1; ENSGALP00010032737.1; ENSGALG00010022276.1.
DR VEuPathDB; HostDB:geneid_420018; -.
DR GeneTree; ENSGT00390000008164; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000002973; Expressed in heart and 12 other cell types or tissues.
DR ExpressionAtlas; A0A1L1RSV3; baseline and differential.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.3110; -; 1.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR InterPro; IPR029318; BH3_dom.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
DR Pfam; PF15285; BH3; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 100..124
FT /note="Beclin-1 BH3"
FT /evidence="ECO:0000259|Pfam:PF15285"
FT DOMAIN 130..256
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 259..440
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
SQ SEQUENCE 445 AA; 51135 MW; 1508A2739632541D CRC64;
MAAAGASTLL VSFVCQRCSQ PLKLDTSFKI LDRLTIQELT APLLTAAPAR PGDAQEESAL
SEEAFTEGRQ DGVSRRFIPP ARMMSTESAN SFTLIGEASD GGTMENLSRR LKVTGDLFDI
MSGQTDVDHP LCEECTDTLL DQLDTQLNIT ENECQNYKRC LEILEKMNED DKEKLQTELK
ELALEEEQLI QELEDVEKNR KIVAEDFERV RAEAERLEQE EAQYQKEYCE FKRQQLELDD
ELKSVENQMR YAQMQLDKLK KTNVFNATFH IWHSGQFGTI NNFRLGRLPS VPVEWNEINA
AWGQTVLLLH ALANKMGLKF QRYRLVPYGN HSYLESLTDK SKELPLYCSG GLRFFWDNKF
DHAMVAFLDC VQQFKEEVEK GETRFCLPYR MDVEKGKIED TGGSGGSYSI KTQFNSEEQW
TKALKFMLTN LKWGLAWVSS QFYNK
//
