ID A0A1L1SU87_MOUSE Unreviewed; 130 AA.
AC A0A1L1SU87;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Sperm surface protein Sp17 {ECO:0000256|ARBA:ARBA00014863};
DE AltName: Full=Sperm autoantigenic protein 17 {ECO:0000256|ARBA:ARBA00031837};
DE Flags: Fragment;
GN Name=Spa17 {ECO:0000313|Ensembl:ENSMUSP00000150651.2,
GN ECO:0000313|MGI:MGI:1333778};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000150651.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000150651.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150651.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000150651.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150651.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC spermatozoa to the zona pellucida with high affinity. Might function in
CC binding zona pellucida and carbohydrates.
CC {ECO:0000256|ARBA:ARBA00025518}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A1L1SU87; -.
DR SMR; A0A1L1SU87; -.
DR ProteomicsDB; 351561; -.
DR Antibodypedia; 32898; 306 antibodies from 26 providers.
DR Ensembl; ENSMUST00000214786.2; ENSMUSP00000150651.2; ENSMUSG00000001948.11.
DR AGR; MGI:1333778; -.
DR MGI; MGI:1333778; Spa17.
DR VEuPathDB; HostDB:ENSMUSG00000001948; -.
DR GeneTree; ENSGT00440000039164; -.
DR OMA; NCESEKE; -.
DR ChiTaRS; Spa17; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000001948; Expressed in seminiferous tubule of testis and 190 other cell types or tissues.
DR ExpressionAtlas; A0A1L1SU87; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:InterPro.
DR CDD; cd12100; DD_CABYR_SP17; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR047579; DD_CABYR_SP17.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR012105; Sp17.
DR PANTHER; PTHR10699; NEUROMODULIN; 1.
DR PANTHER; PTHR10699:SF16; SPERM SURFACE PROTEIN SP17; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF016533; Sp17; 1.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|MaxQB:A0A1L1SU87,
KW ECO:0007829|PeptideAtlas:A0A1L1SU87};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 14..51
FT /note="RIIa"
FT /evidence="ECO:0000259|SMART:SM00394"
FT REGION 84..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 130
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000150651.2"
SQ SEQUENCE 130 AA; 15065 MW; 1D70595613C1AF92 CRC64;
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR EKTSFDPAEW
GAKVEDRFYN NHAFKEQEQV EKCEQELAKS SGREETPVTP FEESTEEERE QEEAAALKIQ
SLFRGHVARE
//
