ID A0A1L1SUZ0_MOUSE Unreviewed; 117 AA.
AC A0A1L1SUZ0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Aminolevulinic acid synthase 1 {ECO:0000313|Ensembl:ENSMUSP00000150950.2};
DE Flags: Fragment;
GN Name=Alas1 {ECO:0000313|Ensembl:ENSMUSP00000150950.2,
GN ECO:0000313|MGI:MGI:87989};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000150950.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000150950.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150950.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000150950.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150950.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A1L1SUZ0; -.
DR ProteomicsDB; 355212; -.
DR Antibodypedia; 4303; 372 antibodies from 34 providers.
DR Ensembl; ENSMUST00000215222.2; ENSMUSP00000150950.2; ENSMUSG00000032786.17.
DR AGR; MGI:87989; -.
DR MGI; MGI:87989; Alas1.
DR VEuPathDB; HostDB:ENSMUSG00000032786; -.
DR GeneTree; ENSGT00940000156030; -.
DR OMA; RAYFSGM; -.
DR ChiTaRS; Alas1; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000032786; Expressed in adrenal gland and 274 other cell types or tissues.
DR ExpressionAtlas; A0A1L1SUZ0; baseline and differential.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:InterPro.
DR GO; GO:0003870; F:5-aminolevulinate synthase activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006778; P:porphyrin-containing compound metabolic process; IEA:InterPro.
DR InterPro; IPR015118; 5aminolev_synth_preseq.
DR Pfam; PF09029; Preseq_ALAS; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A1L1SUZ0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 2..116
FT /note="5-aminolevulinate synthase presequence"
FT /evidence="ECO:0000259|Pfam:PF09029"
FT REGION 58..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 117
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000150950.2"
SQ SEQUENCE 117 AA; 12480 MW; D029AE23CE18D7CE CRC64;
METVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEVG AKPAPRTLST SAVHCQQVKE
TPPANEKEKT AKAAVQQAPD ESQMAQTPDG TQLPSGHPSP ATSQGSGSKC PFLAAQL
//
