UniProt: A0A1L2ZMB0

Database: UniProt
Entry: A0A1L2ZMB0_9MICC

LinkDB:  A0A1L2ZMB0_9MICC 
Original site:  A0A1L2ZMB0_9MICC

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Ontology (5)   
   GO (5)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (13)   
   InterPro (9)   
   Pfam (2)   
   PROSITE (2)   
All databases (22)   

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ID   A0A1L2ZMB0_9MICC        Unreviewed;       326 AA.
AC   A0A1L2ZMB0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   ORFNames=BHE16_04130 {ECO:0000313|EMBL:APF40337.1}, HD598_000286
GN   {ECO:0000313|EMBL:MBB5511599.1};
OS   Neomicrococcus aestuarii.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Neomicrococcus.
OX   NCBI_TaxID=556325 {ECO:0000313|EMBL:APF40337.1, ECO:0000313|Proteomes:UP000183530};
RN   [1] {ECO:0000313|EMBL:APF40337.1, ECO:0000313|Proteomes:UP000183530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B18 {ECO:0000313|EMBL:APF40337.1,
RC   ECO:0000313|Proteomes:UP000183530};
RA   Luo Y.;
RT   "Genome sequencing of Zhihengliuella aestuarii B18 antagonistic to
RT   Plasmodiophora brassicae.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:MBB5511599.1, ECO:0000313|Proteomes:UP000580797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 105783 {ECO:0000313|EMBL:MBB5511599.1,
RC   ECO:0000313|Proteomes:UP000580797};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
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DR   EMBL; CP018135; APF40337.1; -; Genomic_DNA.
DR   EMBL; JACHDR010000001; MBB5511599.1; -; Genomic_DNA.
DR   RefSeq; WP_071893819.1; NZ_JACHDR010000001.1.
DR   AlphaFoldDB; A0A1L2ZMB0; -.
DR   STRING; 556325.BHE16_04130; -.
DR   KEGG; nae:BHE16_04130; -.
DR   OrthoDB; 9807233at2; -.
DR   Proteomes; UP000183530; Chromosome.
DR   Proteomes; UP000580797; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   CDD; cd02134; KH-II_NusA_rpt1; 1.
DR   CDD; cd22529; KH-II_NusA_rpt2; 1.
DR   CDD; cd04455; S1_NusA; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   NCBIfam; TIGR01953; NusA; 1.
DR   PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR   PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 2.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR   SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183530};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription antitermination {ECO:0000256|ARBA:ARBA00022814,
KW   ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW   ECO:0000256|HAMAP-Rule:MF_00945}.
FT   DOMAIN          112..177
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
SQ   SEQUENCE   326 AA;  35708 MW;  CA86443F0D24F041 CRC64;
     MDIDMAALRE LERDRDIPIS VLLPTIEQAL VLAYHRSPGA IDKARAEVDR KTGHVTIWAM
     EYDENDEEVG EFDDTPTGFG RIAASTARQI ILQRLRDAED DNILGEFRGK EGELVSGQIQ
     QGMSTHTVLV NLGTVEAILP PPEQVPGEKY PHGGRIRAYV VDVRKGQKGP SITVSRSHPN
     LVRKLFELEV PEIADRTVEI VSLAREAGHR SKIAVRSRKQ GVNAKGACIG EMGSRVRAVM
     NELGEEKIDI VDYSDNPAVF IASALSPARV TNVTILDENT RSARVLVPEG QLSLAIGKEG
     QNARLAAKLT GWRIDIAADP STSREQ
//

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