ID A0A1L3KH04_9VIRU Unreviewed; 2777 AA.
AC A0A1L3KH04;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Beihai picorna-like virus 59.
OC Viruses; Riboviria.
OX NCBI_TaxID=1922604 {ECO:0000313|EMBL:APG76708.1};
RN [1] {ECO:0000313|EMBL:APG76708.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BHBei77099 {ECO:0000313|EMBL:APG76708.1}, and BHZC37451
RC {ECO:0000313|EMBL:APG78921.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
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DR EMBL; KX883321; APG76708.1; -; Genomic_RNA.
DR EMBL; KX884500; APG78921.1; -; Genomic_RNA.
DR Proteomes; UP000201315; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR014872; Dicistrovirus_capsid-polyPr_C.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF08762; CRPV_capsid; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000201315};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT TRANSMEM 942..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..711
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1600..1726
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT COILED 131..166
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2777 AA; 315882 MW; AA0B8A14760174BA CRC64;
MGIYSIPVEE EKKEIPQVVQ TPMKSLGRTQ DDLMGVKRAK MEFKKAKKKA IGLNAINKRK
ERSRMKTSER VFSDCFQIDT LDEAIAQEIK ALKIKESIES CAKLQRKKVD EKIEQTKGSP
NYLRRREAAE LRKMNINKKA AKKIRKKKNQ EERKKTKIHV ESLEETINID NVDVKHENEV
NSLNWKPYEE TGGEGPEFSV NQSPMYEESK TYFPDQTSDI LQKARIASDE ACAQLDKKLL
EIQQDVRQRD PTLKLSELFK KYGFKISLDL LEKFYFILQL VVDKFKIGYD YLVEFIDKLL
VLCTPAIEEL LQVNFSKVFD WTGYLLDCVA LFIAIYFIRD NAYMGIFIHS ITSKYIGDAG
GILLSLISTV VSIMTKQSEI VVESFDCVTS FLDTILNSEV FSCFRTLFLS LFSFKVFGDR
AKGILTLFFG GKEHGSILHL AKSVFVVIER LIAISALILG GMSISEALLS QNPLDLYVKK
LNDLLASDIY YGLPKEGNIS ANEFLTQFRD IQNDRNALLK TRIVNNSRWV YIEGLYRDAR
LRSEGIKINI ESHRVTPVSI VNCGDPGVGK STMLDTVLRV LCSVHNWKYD PNIVYAKVIS
SEYWEGYDPL CQKIIHLSEL GNVSKKIVEN SGDPNLNLFC TLVSQEKMNL NMAAVDLKGK
ISASPYVVYI DTNNESLNAD AATGHGAAIR RRSIYIEQKV NEPYRKEGGS CELDVSKIDG
VDYDDIWTFT VYKYQSVDAH RSKKEFNYIY NYSQVVTLLV DLFRAHAIKL DNATYVSDNI
GSKISKIMEA KVDVEAEEMK FPIVAMSCGT EFDTTPISYF EEGKGEESHQ VNWCTCGNIE
GHTVYCQLYE GRHYINERMF EVSEQRGVIE VEANDNYITR IVEVIHNKFY SPRAYNMFQH
CHRVAAYTSK VGKYCLAEAN VKMRLWALND YIKDEFQFDL KLLFILLYLF LIIYSLCGIG
YAFFIGINLL FFYAHQIKNL SLSGLARRYV KGKLLLKQDI AERDRRNAWN DLRDYVTDDV
FVADSLSFLS REVLCVAGAI TTITGIYTLT KYLRRARPQT EASDKDMNHI EETEIYGVSK
SYTRVASPQM LNWTNAQKNV VRATYTGDEA SFIAMVSGNT RHVMITRNEG KDIIVTYAYA
LMIRGRYGLM NKHSFPEKGL VSIKVNTTGL NQQASYTVET VVNCEKLIAV HEDVVLIKFQ
GAEARDITKH LYKQILDIGT GFVVTTPISF VLDTEKLKIR MNGDRGYISY SPTYRYEWIG
HCKGKCGLPL IAKLHNNSFC IIGLHSAGSD ANPTSYAIPL ATIDWTKIDE LRAESIELDI
SDLPLISPSE RSMTRFIPLT TIQYYGRLEN VTVLKNQKSH LQGTFFKKSS SLRKFLYDRS
VFDITEFTRP VMKHKTINGF YICPYQNNVE QWCGPRPCPD LKILGEAVKV YFDRVSNGLK
GITIQPWDVD TAINGAVYDP FCRKLNMSTG TGYPFIGKKY QYFERIDVKG LIKYEMIPEL
KLMIKERIAE IESGKAKPFI YEGCLKDEPV SLAKASIAKT RLFSSGNLVD LIIMRMFLGP
ILTLMIEFND LFCTAVGIDA HRDGDKFMKF FEFKEQDWDF VFGEGDYKYY DKKQGTALAR
AMNEFIILLA KSLGYNERAL RFLSFILEMN VCPFYIVLGD LYCVPGSQPS GMYGTAETNS
LKGALMIIYV YLKLGGDPQM IWDYLRFKTY GDDLLTAMSK YILGFFDMVK FSSIIESDFG
LQFTSSDKTT ELQPFIPSSD ITFLKRNIKY STKLKRFIMV LDISSIVRSL EWVNPSDEVS
PEKQMISCAQ SALREIFFHE NINFDEFRTL IIHDIATNMR FNEKEIRSML PTYDDILLSL
QPQYNDVSGG STSPSKMAVS KTREDDLEVN KGIIVTESLD RHSNSEWSAE EKDHERDFNQ
NLKEKFVENQ MALIRMKKEF EMLVNPNPNV TYFTAMRSEL YHKNESYKKA MDKFWGAKFA
MDSLAGDIAT LRRILNGRGV HVESDSIVIG NTPDEVKHYE NVQDVSGEPS AEMSSKGFPY
DSRVSDIGDL GEFLKRPVLI YNSDHYGWTP NAYGGIQLQP MSLLLLNPTI RAKLRNFAYM
RATLCIRVVF SGTPFHSGKV VVCLMPLSGD NLNLNVWDTV DLTGEFSTKY LCTQVKKKII
SVHDNKPLEI RHKHLSYLPL CRLFNSWPDT LGASSVFDDY SGYAELYVRN LNDIRSVSNQ
SGHVSASIYA WLEDVEIGTS TGTKMEIVVE SDERKVGPIE KITSKMAHAM YELRNIPYLG
RYALASSSIS KGISNISAIL GYSYPTKYND PTYTKHYVLQ NGCHTIGMGT GKKLTLDPGQ
EVTVDTSFCG IDNDEMVISY ICSIPSMITK VEWITSSTPM IPLATIPVTP TLPSCTGLIG
NYRYTQPSNM SFAAGPFNYW SGDVTFILQL VKSQFHRGKI AVVWEPNGYQ MSLTTGDQYL
AWQNTVILDL QETKEAEFTV HWKRKSDWLP LQYIFDTGYA DTSADAANGV LKIYPITTLT
SPDDTVPVEI NIWSYSKNMR FNVMNRNQYL LNTSEVVVES LEFLVNDDIM SYSLNEETNS
GDNISVLHFG EEPISFRALL KKFDTIAPIT CTPATAVRVV VPIGKVHDEN NLFSYLYHAY
LGRRGGMRFR FIRAQGVSDG DISTAWLNPP SSMFLDAISV DNTASLKHTM NNYVRFYGGN
ERTFEIEAPY YSANLMTPNY NEGSLARNWV RQYVRYVSAS VISGSTINSQ FGVVDRAVAD
DFSFVRYIGP PGRRELF
//
