ID A0A1L3KJ55_9VIRU Unreviewed; 2257 AA.
AC A0A1L3KJ55;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=SF3 helicase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Hubei picorna-like virus 82.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Polycipiviridae; Chipolycivirus; Hubei chipolycivirus.
OX NCBI_TaxID=1923167 {ECO:0000313|EMBL:APG77437.1};
RN [1] {ECO:0000313|EMBL:APG77437.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Spider133992 {ECO:0000313|EMBL:APG77437.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX883688; APG77437.1; -; Genomic_RNA.
DR RefSeq; YP_009330058.1; NC_032222.1.
DR GeneID; 30684905; -.
DR KEGG; vg:30684905; -.
DR Proteomes; UP000204491; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000204491};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 840..1020
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1961..2101
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT COILED 642..669
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2257 AA; 258690 MW; D2957CC5F71C5229 CRC64;
MKMSQSNNKS NKGLAAKQEK IRVYGKTRNF KANKRIQIRF NYAYTDKLGF EKKTRFEDGY
QWFVENLAKN VYSVEGFLII PSECIMVRYG SKNYQDVDGR LVATIFNGLR FVTNLDLDQV
VEMAALMSTV RMMTMKKHLF ITDAISLFIH NFRRYARDLS VVNSNIDIND QVAYERLVEK
AKDFRVVIPY KIGDEIGDFG DHIDRIISSE KYGIINDFDM MPKFPPTFEE MENIITKKIS
EAKKEFDEQT TVQGILRVYE KKLSGFETER FVSSFETVYI QKMQPILNYR CPPNWQNELI
QMMVLNVIDG EHITYGISEI EVPITELQAF KRTIQNLGTL RYMDFCFVPE LAEEVSDNEV
AVVEIPEYTS DIRKYVSLFK KEIEYQRSLQ LMAQRFALNL KLENPDNMFF NAYKILWRAM
ERRELDVSNG RGPTAEVESN NINRVEKLHL HQDCRKLQNT TLDFEEPSTS KKEASQDLTD
KNVFRRALDA FTQPVKSLKS SFSNIEDKIG DATHKIKEVA NKISVKLDDK GFATLAKGFS
EFDGSSFSAT LGSIKMLANT FFDQALQWIY KQFGFNISIK LDVSDLVITY ILWINTTSSQ
VKLLILGYLA MQCGILDFVF QILKSIALKV KDYMTNEDTG FAEELEKEEK ALQMKKQNVM
EDIEKKKDKI TSIFEKAEEP DETLWEKVWS GLEHGMPIVL GLGVVGVAAA FAYDAVDKPG
KIGDKVVKVC RAMSFIGLGL GSISAIIKHG MGIIKVAFDY INHYIRGKED TKIKKMETVV
NFLKKANYIP GVSNYVFATD TAAAVIFMRH YLEIPKIDKF IHEIEDATLR TTYGIRRREM
TQMYGAVKAA LHVAIQGAEI MHIQFYSEPG AGKTDLSQNV IKDLAAKFTE VRDALDEKKG
LPKMPNLDDD TVYFGMECEK YKDLYYGQKY MIIDEMNFFQ AEDQESIQFK LGLFSGKPTV
ANKAAIEDKG MLFNLNMVIS NTNNPFPAPN DVISPEALQR RRILIEAKVK PEFLTDGHID
PQKIADAGAN RNNSEHLSFT IIDPIKKPPQ PVNSSYVDLD YHQLVRVLKV KVENHILTEE
SRLENRTGAY SHVRSHIESM INRVEQSTIN GQDVRAIKKE ILRLAAYLKN AKTVDFSDPA
VINKEFRPMN RLVAATIEQY NRFRRAYDFI AAPFTSETAH QHALGPCIDD CGFEDVNFEG
ASILINRCPK CHYEACRGFQ LMLNASDLLN IYPHTSYPDA EPIIMTEDTI LERGENAGCT
TLKQYQDKKG SPYVVLEKCD DFTPMGSINH IFDPTKFNIY KIKGKEQLVY EEEIPSDEDK
RDSLLAYMRY LETMDSMSEV KKAINRKRSR YNANLIRLTY MERLKQAASS TWNTIKNVVV
NFVSGCLGYL GQGLEIGITS MIAIVVIWGS LYGIGKLLSG STDTAAYSKS IRTNTISRRL
EDTSLFVENQ NNENVKYARR GQVIMIAMDP TRTHLIGWIN GCCIQGNVFM VPNHFLKNLK
GTVHLLVLDP TKLTTSNNEG IYEMDVKVSD FKQIRGKDAA LVALPKIRMM VSLKKKFITE
EDLGDSNKNF STFRASYQGY RAPSDFDNIT VADFRTRINK NLYASEVMDS NPDPQNSSKF
DMHTFKALGD VRFGDSGSLV VHTNTKMQSH FLVGHMIQRS NIDRQPVGVF ITQEDLDMAL
QSFAVPQKLE VCHYQGKQLP ETHEYYKVFD FPENVCLADK DRSINETRGF AKTPIFGVFT
VETEPAILNS ADPRIPEGAR HPLKVSLNKS NGQNPPYISE EERDFMVKSL IQHYEKQLSY
PIRTIRIYNT LDAIRGTKEM GSVPINIHSS AGLPYADMPG VSGKRPFIRY DEEQKTYVVQ
DRIINDVKLY EHLYKSGIIP QNMKLEFIKK ELVGPNKIEN PKTRTVGTGN IIHQIVYNKC
NKALQLLVKN AWREGKTTSF AMGLDLEIHG NQIVQGLKYI DYMYDFDVKA WEASINYELL
TMANEVKVKL MQKAYASRGQ QCSYDYETIS QALVTDYTDC DVHFKDVIYA KNSGLLSGHP
GTFIENTDVH IMLVYLIARR ILTKHKKLGW ANATDIYNNI KVVVAADDIV MAISPLMRPY
FTPEDIKWGY STVGFEITSA DKSPEINVKT VEEIQFLKHK FKKDKEGIYH AYPLTSIIYQ
LFNWYRTDTK LGREELLLQN YSDAFRFSFF IGEEFYENTR ERFNKANLNN NIQWNFTYAE
MRAMILQDRE ELNMFEHSNE PKIRAEAENF YDRFFQQ
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