ID A0A1L3KJ61_9VIRU Unreviewed; 2872 AA.
AC A0A1L3KJ61;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Hubei tetragnatha maxillosa virus 3.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923245 {ECO:0000313|EMBL:APG77448.1};
RN [1] {ECO:0000313|EMBL:APG77448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSZZ2994 {ECO:0000313|EMBL:APG77448.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
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DR EMBL; KX883696; APG77448.1; -; Genomic_RNA.
DR RefSeq; YP_009337339.1; NC_033122.1.
DR GeneID; 30854872; -.
DR KEGG; vg:30854872; -.
DR Proteomes; UP000202893; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23169; ps-ssRNAv-Picornavirales; 1.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR014872; Dicistrovirus_capsid-polyPr_C.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR InterPro; IPR024379; Waikavirus_capsid-1.
DR Pfam; PF08762; CRPV_capsid; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF12264; Waikav_capsid_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000202893};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT DOMAIN 1397..1557
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1942..2143
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2418..2552
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2872 AA; 324380 MW; 14E0BBCCE0F9EEAB CRC64;
MATTQGSSTC ASSFFSESSF ETDDFHSTGS PVLDTAHVTK SYCHNCNFTA ERVREVSHLT
AAEKVDFMYN WIRHVNSCHG FDEDEVDCYS EEESIEYESD EEVNRLGVWQ DDLFQEEQES
EYDHELYPSE PEESEVGDVT EDFYRMTTAE PEFLMVDGDR RITVKLVGVK SERIYPLPLS
AEDIFEVFDE YLQTSPFFTQ KLQTVRSILG NRKFARRVTR YLKQSRMTEG TAKFWTDWTF
DTRRHRDDFV KHLDKKIAKA EMAMQQDEVQ VEENTMFSDQ RETVQEDGFI ANQQQVSGQE
VSMQEQQWHV RNIMQKPMLV GVIPWSTKDE VEKLLKAYQV PGDTIVGPHY NQIATFAFWR
GHPTFRIQLN GTKFHCGRVI VAFIPFYSKK KHTDVLWSTN NLTSFPHVML DASISNSGIL
NIPFAHYQTY FGSVIPSAYS FLGQLVVSVF NRLSTSTTSS QTLDISVWVS YDNCELHQPC
HAHVPQFAQA ESGVEGAVKS VLPMITDLVA PGASSVIGSV AGGIANLDKP TDPVEISRWV
PNAVSSLNFG DGLDKSNRLS LRPGTATVTE VENISTTKDD MNLLELAKIP TVVSRVVWGT
ADAPQALLRT LKVNPCLWTA HGNGEGADPP VDVYTVNLLA YLSRPMKYWR GSIKYRIQII
ASAMHSGRLQ ISFTPGYLAS DFNNSNYANT FIVDLQEKSE VEFVVPYMAT RPWLRCDKIQ
EITTTNAGSV IGSTAVGFIK IHVLNRLCCP DTVAQHVDIN IFNSAGDDFE LAFPSDLAFF
RGIGNLVVQK NEAKAESGQE FVNTRTDTQA PQTITAGKGL LSSSVVTTLS ENAMDLKTVL
RRYQAVFTDS GVKIGTGVRK FLHAFQNTPT LSGVHKKYGV TAVQTRTHLC HYSELFTFWR
GSLRYKYVYH TKNPITFTVF HIPGVFGPDK FDPQVVSGDF SDLLVALTST GAQIAVSQIQ
NSIEFEIPFY APYQQLKTMD GGIMNATAAT GTVFIIGETT EQPELHYTLF QAAGDDFGLN
YLRGAPRVQI LKGKEIARDM SDAATSLYVG MKPTFAEKKS DSEKEESEER APAKAEMFSG
FRNPFTQTMN TAAAVERACN TSTNLLNSLS SQLGLAARAG TSDILEGEED GTDDDDDNGG
IVHQLLSALG SFATELLKNA GMKIKNLAVT IANLVSGFNS FLQASSFVVK VCAIVTVVSE
LFGSVMTTAK DKLFWLVSKF LNGRTEGNQR LVAESSAAIF SFAPVVMATA AVGLLMGGFA
KLPNDKETND VMKLVTERMR TFNFGCAAMS NLKSCYTQMK ELFDWIQDTC LNWLAPQFLA
SMKLQREFHD VETWTKFIDE TMATDYVDRS NWDTEFRSRI GRASEAAERY NQYLITGRIG
KEASIIREYV RKCYEMRDLV NESHKALPSR KDPFCVCIVG PPGVGKSGSV LYLADKVMDD
QNYPKQKRIC PVNPIAKQFS EGYAGHAAIY MDDISAFTSE EQYHHFFNLK ANTKYALDKP
FDKTDYFRSD FIFMTSNIPY PTPNFINDLD AFNRRRDVLI EMTFKDEETE QAAKDGVPGT
LKRDYSHAVF RFLNPRDETA EKGPPLTWEQ MEEEVKNRAR LHYINQEKQL RYLLSAAGYT
APPLISELPP DDMSKEDQLA WFQRVFHPVE EPIVPEAGDD GSGWWIKHHS EVEFDEEKVS
QHPLLSLYRP ELFSYLQWSG SEFCLSDKGL EQPNIAAEFA TLKCDFNRHH GNDWEKAKKD
MLITLASVSQ FKGVKGALDA TKVKLVELKE GLKTYWEKAK KWFEENCPVL GVMRTWPAKL
ALGLAGVAVL VGFGQRIVHR CLCAVVTHLG YRCPKCGKWP ELEKCRWKDW LIREWKEIYG
ETVDYVAGRV LTAEEEQGID ELRGRSFQGI RAGTEMKLNA EVGPYSDITA GGKQVRIFAH
HGPYNNETHG GARQRVFADS GQKTDDLITN RVIPCLYRLR GVHGGVPAEV NGFALGGRLL
LIPSHFYDVM DGKFELYYGK EWMVVLKDET RARHIPNKDL VIFTMPVSFH EHKSCVKHLI
SEKQLGLLSK TECLMMKQMN KDYVMAETVT ARTFKELHYE LDGEVPTEYF VAGLWEYRSV
ASPGACGSVL VTMDEKVEGQ ILGFHCAGNG TYGYSQIVTR EMIEPYVTTK LGTPTPECTK
QFGRVIPHGH FGRVGQLPKG QGVRQSDKTE IIPTAIQGAV SPPVTQPAIL SSRDPRYKGS
DNIMTKGIAK YGKPAVPFDP RHIAMVEESF NAEIEQWEVP RKAQVLNMLE TLQGIELLDG
FDRLPMNTSP GWPYTLTRPR TELGKAYLFD AEKTRIENKE LEKKWSARLA MAKLGERVES
VWTCCLKDER RPLAKIEAGS TRLFVIPPVD FSLLMRMYTL DFSVAFKVNR HTSFTKVGID
TQSLEWTKLY NYLAECSEYV VAGDFERFDG ALPPEMTHQF FKHCNYYYRR HGTCTEEDER
VRGVLADESV HTVMLANEDV FVTHVGNKSG NPNTVNINSV ANYYYMAISY LGLAERYSPE
NATMDKFRKN VRIAIYGDDN VLAIKREILE WYNQLTIADF LKGYGIVYTN ETKTGLTKYK
KLDEASFLKC SFANHESIAK VKVPLMTEAT ILELLNWTRK APDQDELLES NINDALRFAY
FYGSKYFNAL RGKVVAALKE RNKTLDVMTY SDFHYWFLFV CGKLPHGKSS AEMNLLEVVA
ASGNSGFARF MTRFLLGVPC GIASSMGWFV RSSDVKRTDE RFAIAIPSGE GKTWLCKKYP
HLFVDHDDIL LPAAKRSLKE HGMSWTRLWD MLDLELPLHD KRILLVHHPA NTRRQMLGSY
MLPKPSHIRF NAYQRMRLGD TAKVMERDQR NKEILTLARQ KAPYLFRDGR RN
//
