ID A0A1L3KJF3_9VIRU Unreviewed; 2628 AA.
AC A0A1L3KJF3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Polyprotein {ECO:0008006|Google:ProtNLM};
OS Wuhan spider virus 4.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923753 {ECO:0000313|EMBL:APG77425.1};
RN [1] {ECO:0000313|EMBL:APG77425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Spider133854 {ECO:0000313|EMBL:APG77425.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX883684; APG77425.1; -; Genomic_RNA.
DR RefSeq; YP_009345021.1; NC_033717.1.
DR GeneID; 30999574; -.
DR KEGG; vg:30999574; -.
DR Proteomes; UP000203297; Genome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd23169; ps-ssRNAv-Picornavirales; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000203297};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 862..1032
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 2525..2628
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2628 AA; 299556 MW; F6E142AF5FB7CC54 CRC64;
MSSQKKNTSV DASSNTVEVV PQEQPAPVSK LDQKAEGQVN ICRGEGVGKI YAHALAFPPC
FGRKQSDYSV MKILEYWSTH SYNASVPYKS FGNQVLHDLM SGKMFNFALG DVNRELSMLV
NSSGNVYIVS DSQLEIDFRK IMMPALSLAN TVREDASTLG IAQYKTICDI VGCLYDPERT
YMVAAIELYI SVKLQHIAAT TSTQNTRFIL SALKMNNTVA LVHQIFCAPT LIAKLTGVYR
LLELHDLAFT SCDWCTLDTL AKFVYQVWAW IMEKTELAKE FLANGFKWKS TDSEATPEEI
KDSEVVEGVK KDQSKEDSQA LRDIRFPAQE LVAPLPCNVC KQPSEVGCSL CGMHLCKGCM
PKNHLCNCYN AEPFFHESLV CSCARNMDCW WEAVAANLNL STPTVKRIVW RWLLRPDASD
FYIALLNMSG TALVPGVNDY ISFATRVAEF LQKPVINDGL EAAIVTCLAF NARVQFNRLE
AGNYERTYAV AYGKPKAYIN INYFPEGAGH YAHCVEPMVD PPTHDVWGAE FVSFDHYEQL
QHSHIQKMNE IYRYAESCRG SFKDMSDFEF LAEESLSISA SSSRQSTPSP SLKDISKIVD
NETHAALNSA QIATSVASSL NESEITTSSV SQVDSLKELI RNFQSYDVSG VTQNDNTDES
TKKEKVDVDQ LVETPPEGSF WELLKDCQWS AIGKRIKEWF KNISTEILLW FEENKIFAGL
ISLVCGIASF VGINIGTFAG GRASAFLKKF SDAQRTMYYT ERSFGSLSSV FSQTVDVAKE
VLGISPCPEV DDFKEDLVQT LNIALEMQKQ ATVSPGTFVN DGKKFLEFAE KYKSLAKIYE
KISKFRDSKY LTVLTPVWTQ LNTVYHSLQL AYNKVYVSIK SRPEVVCIYI YGESNIGKTH
MAERIVDMIN EYTGRSLSVY TVSKGNDYWN GYAQQDIIRI DDMNAVVGNE QDIDSVNVYN
ICSSAQFNPN QAALEDKNIM LNAKFLIICS NHPTVPSNSL VTYRYAWERR RNLFIKAEWP
EHEKCARGIM NCEHIKARDA RTEALKGKSD YAHLRLRLCN PVVSYKPDET ERPVQTLRRG
KVTDWAVISE SQLDAQGVVT DIDTIVRGAL WWENKYRVEY ERKLLATPQG QLYKEQALSW
EKKPFIMLAG DPGTGKSYVL QRISEKYQGN ILQINTESDF KDFHKNNFKA DNYDLVVIND
LSAYALNTDT TALRDFVQYI RTTYDENKVP SYLLVCAANI GLLESFLNTV DPTNEMFQLF
IRRFNRITCQ FKRRPNPKLT KIGNCIGLKL PTHYIEKDIV DKSKTPEFVE YYCDGNLLSQ
ESLVSAICFY KPKVVEVKQK FGLDIKDKII PDTVITFPLS TDDFLNMINK TNISQILKVI
TSGKVKTYSK KGMTLSNLAS KLQKIVKGCG DLKGSLILGL DDLLLQAWNK NLLKEFMGSN
IVMHFSDRMY YIEANVEKEE DITCGQLTCQ AEIIQKVVEE VEYLKEVVNM TTVFNEDRAF
LPHWVILASE IFSASLGVAV LSVSSVLSVM DQNETFKARE EALAMRSVFE EAVEKVKRDT
TTYIGETITG ASPYNVNLLR PGPKARDADQ YSHEDVDPIG YPDLANELET PKGKNNGQFN
SGKGSRYGFK RRDHVSWEQE VKHQSGRDDF VLNRDYLKSL PVMEQVKFEC ARGKPIQKSL
IEQVSHDPQT KTIVEKLLKN VCELHTISGE RLCSGIFIRG RTVRTVSHLL NEAAITQLRV
FTQDKKAYPV TLLRNDRTHH ILDLKVDDIH CPQYPDITQH FPDNSATIHE GSKSILVTPK
IDPLTGKLEI LLRPMFVKCL TYKRWTDGDH NVAWHYRGHK IGYSATGSQT EYGDCGSLLI
VCDPTITTGK CIGMHFAATQ ETALASEFRK DQYEDTLKYQ CLAIRENEYM IPDSDPDIPS
YVGRTKHRVF LPSKTKLSRN WYPVGPELVE PSVLDRRDPR GPPKDMLYDE CEKWLQEPPQ
IPAGHLDIAR GVAEELAHEV ADMFEEEGVK LRKLTSKEAL NKLRECDKSE PVNMHTSAGF
PYNIMTKQKG KAAFLEVDDQ GIRHFSKKPE NQKYVQLIQT KIAQIEDDKK SAEEQLGLVV
FQIFLKDEVV KKKKIYTEEK KTRTIGAVDL PFSIVYRKYF HCAQAYMLEY WQKLWHAVGI
NPLSLDWHYL YTKLAKNSVM GMDLDFKDWD FSHAPVLWDI ISTFWIILYQ RLDPNCTEKD
TRIRKKLYKF LTFALLLIGT EFHVIRKGLI SGYPGTSIDG SNINVFILVT AWIIIMVSVN
PRIANYTGFK EDVAVYVYSD DWYISMSQYV SKFFNGITIA KIYREFGFNP QSADKETEIQ
AYKPLNQCTF LAREFHLWNG FWIGPLKELN LNKSTHFCND RVSHYFWESP DRVCQSPDIV
ESVYRSLLPN AALRGKQYYE TYRLIYNKVV AVTGGPKAPS WQDQMAEMFP IPKEVKFPIG
FEIVHVPQII EGWQHPLPHN YKAYHNRTSY HYGPNYRYNG GPESNKMTKQ FKSVLELVNK
IFKKDYNSVL VNKYPPGGKI PWHKDNEPCL DLTSGIVGIT MCGDGKMHFK DTEREFQFYQ
NPGMAYVLTE ENLYKYAHMR DCHTVETYTF TFRRVVPRES SSPPQEHN
//
