ID A0A1L3KJU8_9VIRU Unreviewed; 2947 AA.
AC A0A1L3KJU8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=RdRp {ECO:0000313|EMBL:APG77698.1};
OS Hubei virga-like virus 9.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923342 {ECO:0000313|EMBL:APG77698.1};
RN [1] {ECO:0000313|EMBL:APG77698.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCM51642 {ECO:0000313|EMBL:APG77698.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KX883792; APG77698.1; -; Genomic_RNA.
DR RefSeq; YP_009336553.1; NC_032765.1.
DR GeneID; 30853794; -.
DR KEGG; vg:30853794; -.
DR Proteomes; UP000204460; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23254; Kitaviridae_RdRp; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW mRNA capping {ECO:0000256|ARBA:ARBA00023042};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000204460};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 281..504
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 2065..2386
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 2699..2812
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2947 AA; 336351 MW; 31CCE25CE81E7A37 CRC64;
MSFAKGYCYM RLFTTLPSGE RSKIRQSLGP YPTMKAVCGA IYQHFRTDDD VFLPMLGETA
TGMMHCFAEA RRKSQVGKDV VATMLTPREF FLLYARLKVR LGAIGGKCYL SWLRQLGLNK
VLALRLEERL GKFPVFEDVM TELMYVIDDF DTYISVPMKV GPRMLHVDSA SHKQRFIEIM
WEKTFYGYRV GASGMDDELP TNAMPMLLGM GGLQHQDVLQ AVLTDAMRHD PVTKQRVIDA
HTHKVKEVLA GGNEKLHVKY QLTDLEKNKL ILSYPGFKFE WSKRPTSHPH AMSAAARVCE
TQYALTMLGY RSGMNLKNFV AMIKDIGGKP EVHIQRGRLN VHTCAPILDH RDDQRHSRST
DAIAQIAANL PNRPRKKLRD HLHDPEKYRA LICHRKSQYC SITAKYCIFI HSTYDMTLQD
IADSLSMAKS DGGVIAVLYD ADMLVKKSGY LPDQKCHWMV TDSENCLTAR FCLRRKRKVI
RFSFDNDSSY NYEHDYNEYV KLFMTCAIRS KSGELYYTEI VNYTLDTAFI RITRSKFTVT
KSTILRRCLY FRDSDDRVVV HTYRYHPTGT DKHWEAHFSP INIIVTRRMY NMIMAYALDQ
ASSRFSVAQI FSYAKSVNVR RVNNGVAITE MEGMPPDELY DLSVAIFVQA FDTRFCANTV
AKTATDEAID TRNSGTAGIF ELMMLKLKDL LRLGHKEVKV HSDGSELPII DVDAEVSVSI
YAKMRMWLRR KRVLKIETEN MVRTMDVATW LPPHAIEYAL DREPILASLD QVGEGTRVCT
DDFETMIRDR IESAVAPSDS RTAVVPDLTA GSEKCPFCSR CCKWRPVVAE VPDVLLKEYL
GYTEINVEGD GNCFYYALIL SLGISLSVTD LKKLLNESRY KPDVCGGGDL DVLLTTDNAF
ANNAVLYLVL YEMRMAVTVV IENQGKDGVS VFSAQRYSPT AVGVTAEVVL KLSKQHYTVL
RQPTSNISEV GSSVDSRVEL DYPKLRTMII GLTPIQCREV ITRSLHDGLT LAKFCDDVNV
TICGKFDYEV NDPDVVLEFD GSGVIIVFGS LERLLWNLFE TYLYSRCTDV ERKDWDDTRH
FKFAGKFTNR ADAKVAEIMN MFGIDVCGKS VLDLGGAPGG VYSMLKGLKA DKVHTYSHPR
ILKYYPRLRN DACVFLKDIR DVNFNTEWDF VISDIADENT YRWDDSHTTF SYQLDAVMTA
LKYGGTAIVK HGNIWSLLAN AKRLSRYFSH FSRVIIVKPF LANPNTSEVY VVLHTYVNIG
SDAISVEGLP HAVVRMMTGA RKMMDSLDGV KPSVETVSAL KKYMEGLKSG NASIVHERGK
IFYSATDDDT TTNIIWFPTD TEADSDVDDE SSVSVSEELL VSDGDSCKTG HHIVPTLPVD
CDTWSVSNKS DAAQSDVTDV IPRCSHCETN MYHDIIASDT MRTSMPERVH LLLCKFFSTN
PDLKYFQGMH YYTNLVIEAN DSVTDDEGLL SLLTALFSHR LSILLTEDDI DLFFDNRSLT
PMLSLLVESE RDSAKLSIIR LWQNIAMTCA HYVIHEWAKH LKRDTIEEFS TFGPYTALPF
VWSMLKRHEG GNYDYMCERE YIDKFVASVS NEVLFNEYKD ALGCMKSEAQ WEGNRLIRYK
VPDFRKTVRR MISRFVRNNI TRRNETETLM LPEKVGQPRR TIADKGTMRS TVSYNGKVLR
TINSSDFRIV PERRNENEAM VDEYDLRLLS KCTVTGKELM LADGKENMVN GRMLSAPRVE
PLKEPTNADA SAFQLLTTDT LSLQLPVVTV CDRDVLLRDL LVIMLDLSDM ERNFCSYKWH
PWLRNVDASY LVRQVCNLSV QVTDRSNGYY VVIHLSDKPT ERRFLVVVCH SGVDIRSCLV
KFVIRFHTEC DKYKFVPILQ PDTMTCSRTH SLLVETLNQN MKHRYKRIVR EICSDDRVYM
KSERRSDDLN EATKIMHDNW ADKGIVDYKY GFKPSFYGDS TTDSRIKNAM AEIIEYWRVS
DAMITNNCVE FHKSMRLHDR RFISSTAESP EGYAVYDRIE RRWIVKSLKQ EAKYEYCCDG
QKMMLFDDAI ALENDVASRY LVVSSDTVLM QDAKLYKGAV NVCQRIGDQC FEDVEVQLVS
GVPGCGKTTE AIRNFTFPCP GTDGDIILFP TKVAADDFRE RLKRQHKTVD EKVLKMHVMT
IDSFLINDRK YPAYGKLLVD EALMLHCGAI FVAACKARVK RIYLIGDVKQ IPWINRTPLR
VTRQNITDIV TPTRYLSVSY RCTVSTAAML SGLYPNGMMA NGTTTGDMQY RITPNPLVGY
TDKSAHYLVY TQGDKREFMA NNKGLSVNTI HEYQGKENDH IVLIRGTSKA LDLYEKIAYN
LVAVSRHKVS FTYVTPNAVK DAVIPMIARV NNTSKPQLMK FSKMSAGYLP ADITMATYPV
EKVENYHDAV LSCTAKYGVE NVAAHFPVLS EVEEVRVLPA IRKVNVIKPS VQKFQAYYDL
VFPGNSTHDM RYDPYHVMHS DLEVFTERTR MNPSYVSGVS RKGKRFDNME PRLRTSMAVT
RPNNQIESLL GMIKRNQAAP KLLGLQDAEE MAKILEKCFV STYIRKDCRQ MYDGYREDPI
RADPAAINNW LDGQPPGTVR LIERLEAAHE TDLTRYKYMI KNKVKPQLDT NAPYVYSAVQ
TIAYQGKSIN ALFCPIFKYL RQRMMPILKK KFLIYTDMSA DEFAESVCRR VGPTVMNDKN
FLEVDISKYD KSQSRVVLLF ECAMMRNFGV PEYWVNLWWN AHESTTLVDK DNHISCDVDF
QRKSGDASTF FGNTMFLMAL MATLYDLNNV DFACFAGDDS LIIGGPNLHH DYSEQCANLF
NLESKFLRCY KYKNFCSKFF LVVDECVYFV PDPMKLLTKL GRHDVVNWTH LEEFTTSMRD
VTASYGDARV CAELAKAAAD RYNVGIDLTP LIESMYLLFR DPTLMREFFG EPQHGVMSRD
TSLPKFD
//
