ID A0A1L3KKN0_9VIRU Unreviewed; 2975 AA.
AC A0A1L3KKN0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Hubei picorna-like virus 28.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923108 {ECO:0000313|EMBL:APG77971.1};
RN [1] {ECO:0000313|EMBL:APG77971.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QTM24820 {ECO:0000313|EMBL:APG77971.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX883931; APG77971.1; -; Genomic_RNA.
DR RefSeq; YP_009337284.1; NC_033099.1.
DR GeneID; 30854802; -.
DR KEGG; vg:30854802; -.
DR Proteomes; UP000201042; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23169; ps-ssRNAv-Picornavirales; 1.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000201042};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT DOMAIN 1484..1653
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 2180..2404
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2692..2826
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2975 AA; 339332 MW; 95F21C2EE4380366 CRC64;
MASYIVPSKS RSGGYAVYSP CEEAVPCGPV YGPKNTRNIY QRYDYLERLA FSLKRKWLKN
AYECQYKLAY YMQNGAIWYD AYGQTWVQVP KELFIEVNNY VWDEMLKEAR RNRKRHNGGK
HNRIKINICD YPCDPDVAWG LHQCEDSEDD APILRQGAKK KERVYHAEVW PEDHIYEQEW
ELVRNPNLLD RLKARLFLFK FVRKPLAYLR KFKVKEGYAS DYKFDANNEV LEEIPLRTYR
VVEQQMEEPH GENEQVLRAS NVVIGETQVE SVADEGLPVV SWVSMSSNEA FDSGFDRVLD
RFTFIDSIQW HMSDVHPQGM MLADMSFPQH AIDKMCQQNR GNVPFCVPFN IYRYWHGDME
IKLQINSNKF QTGRLQVSWY YYDTKVANDR DNMWICSQLP HCIINAGSSN ESTLVIPYKH
WKPLLSTRLR KGYVKPLHLG TLFIHVLAPL TIGPQATSPK SASISILVRL RNSKFTGLAD
GGIALSEQQM FKPSALASAA SSVLKQFNCD NPTSTSVVPY LVPTGSHSWC AGTGVTEVLH
NLRLDYNCLG VNRAIDHGTS ETTIANIVSH FGLLEPFVWS VDGDKNNKGS VLFEMNVHPI
VDKSKVHKWN HANTQLSNYA IPPVGVVSSM FMYWRGSLEI RFDIVASQFH TGRLLVAYVP
GISGGTQVTL EQARNSAHAI FSLQESQSFT FVVPYIADKP WWHRRYAGPQ RRREIAAPSK
LFVFVLNPLT PMDQVASTVT VLPYIRGGSD FEVAVPVQPA LGLNWNDTIF IANDYFMRTV
PGYAPIYFST WHSFGTGRQL IARYGPGSDH VAQWTLPNIP APPNSYAIWE LQEKINITPK
GKPFTSEYYL CAWKDSGYIY MFPVLKKEDA KAAALCLYKG QKPTDFMSYL VQFSADSSYG
KSNPAYCRPE YFSVEEITDY EVIEKQSDER GVVENVMSPV GTLPSSSYGI TFFNENFGDL
KDLCRRYQLL YSGAVELNVD GINGRDLALF TFPAIPRGLD LVTKNKELIW NIMRDGHIPL
ICDGFRFFRG SLRYKIVLPN DFDFNVWVQH HPDKPFDGPA VLNAEFKNDG ADLVRNHTYA
YYIQSTKVNN IVEFEVPCYI AGNYLVTGKR GEDANTDASD FYSLGEIAIG IDACCASKSS
ISFSLYYSFA DDACLNVFTG FGAKVFCDEA YSYAEPQMMS WLSSVSSATA SQMLGSLVTK
TVDGSVSRFE NRVKNKVMDA VTPLAEELSK EVLLAKHGIE TEMHEWMSNV GMTVALSQLM
HVLVNPTPAS LAVSFISILA IMCQASVSAL FKILQGAQEG LTKLFTRFWP QIAGQSSDLQ
GDAQQHAEFQ SEFLDELSKQ DVHHISSIIF TLWASAMGIT CVGPSKYPNF MRGVFTHVGI
LNNVGTLLKN MSDTIMYCVR HLLGATSEKR RLEMIVESNV IELREWVLEC NKLLDPRMFN
NLLRDQQYSN RVFDACLYGS ILVTEDLHKT CPKPRIILDT YKELCKLRDR IIAMGNHPDV
RFECFVVWLA GHRGIGKSFM TDTICAELLR AINYQTNEAM IYWLTSTTKY WNGVRNPPVI
ARDDAFNLNG TLMEEELGNY FMIKSSSVLN PNMAAVEDKN KRLNPLIYFL NSNFTFPVIS
PAKLPSAVYR RRQALIEARF TDEILQKYGA GDPENISSAE ILMPEERENF KHLLFRYSRN
PAVDKSEFWT NWMSYEELMQ WLRPKFIQFY QQEQKNFQRR VQTAYSLSSS GVHDFNLPDL
EVNSSLRSRV EQAKQLAARR LLEMRDETIE DPNITSIVKS WGQRLVDWWD CRVEKQSPEP
TPGCSFWDDE PIFQGTTKDL GESVKFEVVR TIFSECGKDM FAEWFAGGVW NPSNKFLEKW
MEYTGLQSET LKIMLEDIQD YRLTSSQFFD AFCPKKEFID QWPNFYPIVL WGIDLRLFTP
TPFNTGRVEG METLDQAVNY WRLASYRVHS RIFRNHAFTH DQIAQKIFGK SYAEIRSKEY
IDFMTTQYVN NLGIHCKFTQ FWLEYLPYCS EVQYCSSRDR FIYKNPFGFT TSVEARCNCK
NCPMRNPMLS RLLAYVWNQT HPNIQLCFNN SSNDSAILED WLEKAKSFAS CAWNHYLKPF
ATLVLAFIIK CIPIIVKILL SLAIAMGIRY TASKVFGPSA EIPNVNFNFE PTDFQVGKNY
FKFDSPKFKN TQNNFNKGFQ QSSEQRNAMA RAIINNTVIL ACAYVENGRR MNVNARCLMV
RGRSLLMLRH YYEECRSVLD KRPTFTLHFN VGGAASFREV LFEDVFGCMK RATANDGKSD
SNYCLCELPN FIPQFKSIIK FFATASQHLN LSRTMDLHCV GDQLYCDLEF KREGKFIVAS
NDEVCSNVVL ENAYTYNVQG RGMCGSVLVC NSVNNGNGAI VGMHVAGAPS KGKGIAEPLF
REMFDCYISH VNYPVVDDLD LKPIDDKHIK LNTNLMLLGK VDAEFSHHES GKSRIVPSLI
AGAVYPVITE VNPLKPNDPR QPEGSHPLYD GCNKHGTGHL VPFPKDIVDI VKEDLSSVLN
TRVLPVRNEV SILTEQQAIC GDPDVPHFES LNWTSSEGFP MSVYRPKGAY NKKWLFKLKE
TQSGYELLGM DERLKTLILA RRKAYREGTV PPTIYVDCLK DYRLSPEKCK MPGKTRIFSI
SPIQTTIDVK VHLGDFMASY KQNFIASEHA IGINPDSLDW TQVVHYLGEV GTKIVTGDYS
NFGPCLNSEM VSVAADNIKS WHEFNHAAEE HCNYVHNIIR EEIMNPLHLC EDIVYQTHNG
IASGSAMTGE INSEVNKAYI RVVYMMIMRE LSPKHASMAA FRENVRLLVY GDDFILSVSD
EICEYFNLET IIRYFQKLNI KVTSASKTDV VEKYTDLSQA TFLKRGFKKH PWRANIVLAP
VDINSVQECV NWVHKSNDPA EALLECCRAS MDLAYGHGPE YYKQHGERLV LACRQHNIVF
QPTSWRDRDN EIFGDGSQGE NISLRMTVPW FMRDE
//
