ID A0A1L3KL39_9VIRU Unreviewed; 2901 AA.
AC A0A1L3KL39;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Hubei picorna-like virus 39.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923119 {ECO:0000313|EMBL:APG78039.1};
RN [1] {ECO:0000313|EMBL:APG78039.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCM51450 {ECO:0000313|EMBL:APG78039.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX883974; APG78039.1; -; Genomic_RNA.
DR RefSeq; YP_009336612.1; NC_032790.1.
DR GeneID; 30853870; -.
DR KEGG; vg:30853870; -.
DR Proteomes; UP000202902; Genome.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23169; ps-ssRNAv-Picornavirales; 1.
DR CDD; cd00205; rhv_like; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR014872; Dicistrovirus_capsid-polyPr_C.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF08762; CRPV_capsid; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000202902};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT DOMAIN 1305..1479
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 2114..2335
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2625..2759
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2901 AA; 327434 MW; 85F1FA80CB5D6DDA CRC64;
MFKQDLQSEE NGIKPYVCVR NGGSRACCRF YPFSYREYTT FEYKFPFNPE DEKEDEEVVS
TNYFASLAEF VLGISYYCVL YQLLNISSWS KIYSGYAECT GKEKCYRLVV ASEKGVLEAE
VTGYHRRTIK QFANYMAVVV LKEYLTEDQV QQMLIYYTDL LSYDDNICEV QAENSHPQES
VQGEEVLTGT KHSNTILTNS TGNTESIPLA IKDDTLSYAS SEDLHQFDSL TERWMPLETI
TITTSQTSGT LLKEWYLPYD LLKSHIINPS LAPFMLFRYG ALSIEMKFVV NAHKFQSGKA
LASIKYDPVG LTDFGDLLPT CLQREHVMLD LSTNNQGTLQ IPFIYHRSFL HLNLQQDTEQ
TIVPSTYARV QLHILAKLLT GANQAVNMNI RPYYRFSKAS FAGMEAVHTV QMDVDAVVKG
MIPTKSLKAV LVGAEAFIDQ LGKTRNQDKP TVTSSTQVIP KPRNQFASGK GIFGGTVLRL
NPQVITSAVE VKQSTRTPRT VLEIAKVWGL KKIMAWTTTM KPDDHIDDII VDLHHNFKSS
NSRIESNVLT PVEYIASLYG FWSGTLECRL DFISNQFHTG AIMVSIQVSN QGTVFQEAAC
VYTKIFHLGD QKSVTFTIPY IYDTIWRRNT AQIYTPYTFE QDNRLPVDHI FTLGTNDFMR
IQFYVVNELR APDTVANVVQ MLAYIRAGPS FMVHSLKPSH LEVTKDVALF RDMPMFNVPA
LAPTAYITTS AEKRVTLTKE LTLDHTKIKF QMEGSLAENP DDTPDFNAGL NALHIQTLDS
QVNIKDILRR PIQLTKAISF NKTEVTNHVS LFIPLMVPSH NMVYSDSYET IYADGVTLTP
TAMLMNLFRF WRGSMRFTFV VEDSLSKNYT HWITHIPHSG VRKIGKIEFP KGPSLVGSSF
ASVPLVANVN ATECVEVPYD TELNWTLCHS ARNNEILSVR DQTDTNAGHI VFTPSCTCDV
TVWWEAGDDF EYESFLGVPS TITRDRLHGV YETEIKFQAE ASLYSKTLAK VNTIMNLPDQ
IADTLTNANN VGDAIISSST KAEKLLVKGL EICDNASAML ENISPLIESL EEKIRESLKS
FPGSIYDSTL FIQNGVEIIM DLVVAWLSKS WAVLGNIFVK AIAKLLGFSA VQTVLKYGTQ
IAAAIRNLVD PQIVVQAPSQ TVTLLGVLCG LVGTVVGVSL EAQNYSRFIY KLSERFVTTG
GIAYLNQVLR FVQSTFEVVR DLVMDALGYA DPNVKALQML SKDTGVISTF VKEANTILNE
ANASLLSDPG FRKRFWYTVS QAYQIQSILA VSPANVVSPI VTRLCTDVIK ASSEKFMDLS
CSPCRYEPFV ICIEGEPGIG KSFMTETMVS ELLGSIGFDR PSSGLIYTRP PGARFWSGYK
NQPVVVYDDW MNLNDSDQIL SQLSELYQMK STSDFIPEMA HLEEKKIKAN PLIVVLLCNG
AFPSCIGQKA IYPDAIFRRR DLVLRASLKE EWIGKDLRDL TEKESMDCGH LLFQRYASAK
VEGSLSTVQK TWSEVKPWLC ATYKRYHQQE TILVRKRIKK FQTQMRLNSE NYLDYSDPFS
LFYTSTIDIM EDTECNPNGW LPSEQLEAAV FKVVDLIKEK KDEVLEFHID SKPENVFQNF
PVGWESLSAS LASGMVFSGG VMAQILDWTA QGVGAFMRPL LENTGQVIEH ECMTCLEQMP
CYYVCGGVRS HSNPDAHHYM CMDCMIRMKR ANMGSHCPMC RVEPMLACLP KHLTRLYIVL
RWVVVNIGDR LVWIFSFFRD FLRSRSMVNS RLLLSALSSL IAFLQGDAVT TAVAASYVGA
GVVDAMYDPE LFVDVARSWI FNPLNMLAPS EEYYTPQSEV GDTAVQCITT DVVANDVVCN
DDQEMEKDPW DVLSPKEEAI MRCERNKKKA NSALSVSKTE LLNIQKKRAS ATPYCMHEGI
CDKLPYLEYR ETESSERYWS YVHSKNNTHN WVKIPYFACQ YENCPFADTR YLDTFVQDYM
VEHEINLAAL TQNIINAPRE GKQYYINKLP PFLRAEWMLA DSGLTDEELV KPFTWWEYLS
EKWAHYKQFF FVIAGVVGGI TALSSTYSMF ASLLNLGSST TIAPVVQVAS NDAHIRHLRG
QRDLRPLNRH STRPYVQSDT TSVVDKYIAR NYVSFQIYRD NVMIYQLSGV GLFNHWCLMP
RHYVSRLRED ASQGYTIKLV PALGRNGIKS HEATVYTFDA EDFKISSHTD AALFKVPASY
PMFKDIRSFC STDKDLSEHI NSRGSIFLVP GSDGSVPRIT DIDIFGRVNS AIISDDKEKF
EIRDVLHYGY SQVGACGSLV RVEHHQRPIV AMHCAGSGQG TLGDGYGVLV TQEALGELMH
LQVVTQCEDK DLGSLSEAKL LFGEEVNVHY LGTVPVEHIA HMPKKSKILP SLIHNQAGFE
CHTEPAILTS QDPRYQHEQS PLYYGAAKHG KKTIDFKSSI VNKAKRALWG GWISSMLPCV
AQPKRLTYEQ AVIGLPNVEY YDPMKLETSA GYPWTLEGKT TTKLEWLEIE RDSQQRLSKC
QLRAKLLAEV ERKEKLRQKG IVPITMFVDT LKDERKSHAK VLKQGGTRVF CASPIDYTIA
TRQNLLHFSA AFMKARLNVM SAVGINAKGP EWAGLVRHLG RVNNNNIITM DYSNFGPGFN
AEVARAASEI MIDWTMMHME GANILELQAL LKECTQSTHV CVNTVYQQTS GSPSGAAITV
IINSLVNLLY ILIAWDQLCG DTARLLNPDI YQVFREHVAV AVYGDDFIMS VSDDFKFLFN
TITIQTFLSH NGIAATAMDK EKVATIPFQS LLKSEFLKRG FMPHPTREYE WLSPLSWEAV
EDITQWVWKS ADLREATRVN CESALLEAHG HGKEVFEKFK RNINKALIKR KTKTLTLDWF
DLDRKFFEDD VGVRRTSYLF G
//
