ID A0A1L3KMA0_9VIRU Unreviewed; 1997 AA.
AC A0A1L3KMA0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNA-directed RNA polymerase {ECO:0008006|Google:ProtNLM};
OS Wenling crustacean virus 3.
OC Viruses; Riboviria.
OX NCBI_TaxID=1923486 {ECO:0000313|EMBL:APG78493.1};
RN [1] {ECO:0000313|EMBL:APG78493.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WLJQ142924 {ECO:0000313|EMBL:APG78493.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX884321; APG78493.1; -; Genomic_RNA.
DR RefSeq; YP_009336743.1; NC_032858.1.
DR GeneID; 30854061; -.
DR KEGG; vg:30854061; -.
DR Proteomes; UP000201162; Genome.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23194; Dicistroviridae_RdRp; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 559..734
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1214..1444
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1730..1858
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 221..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1997 AA; 225399 MW; BE31AC4E8F15BD1A CRC64;
MDKCNDNSLS ALMNNIDLAP QPDTDYDFAT ESDIKEYSIH SLAAAGALNI IQYLIDDYDP
RDQNLQSTAL YNYLRQFDFS EDSPTLITDL LTIRENFMNF AYINDTWDQV KCFLHLLTYK
GTPMYVTDFA GDDPIVTEIG FKNFKIKKTY YCDFDEFSYT INVNFAQLLL LLSGDVEENP
GPNNTTQSCE ETQRKKINQM QREIEKLKKL QRQHQNFMQR QVELEKRNRK KKRENGADRK
RYAQSAVEMA KEAVQSCART VKNIETAKAA GYLATNWVVP GLGTALATVV NGPKITAAID
KINPTIDMLQ GVLKSLTEAA DQLKAVFGIP KDYDVLEILI ACVSICQHLK DKNMLLLTVY
CTNLARHLGI TLGSLMSLIP NICPTNITYA AGSDTRQVAQ SLVSDMFSTA VKSPELLPFS
GFLAFFCGIF SLLCSGSVPT PAEMAKHFST VGRAAQGFKA VRDLFVWIFD YLAEIYYTTV
YGVSAEEYKF IQNFPQIENL YAAVTIIEQF DKSLIDASAA ISEQIMTVGF QLGEYHSQAT
RVNSRSNTQM IQSLQKRIHS QIEWASHSPA RCHTIRTQPV AVYLYGHPGV GKSVATEVLK
ARIYAKYLKE THTDFNTISF PRRAKNEYWE GYTGQPIVIL DDFGNVIDSQ QKPVEEYEEL
EYMVNTAQYP LKMAELKSKG VSNFTSEFII ASSNQKYPAI VSLVDPGAVF RRFHVWAEVT
IDPAYGVPLG RDDRGGHYYT FDKKTAAEKL NCTEDKIPPL VVDHYRFTCY KVSHNKQSGN
AEVYYIPGKN NLTFDKFWEY FCEENDRRKQ DSQGLAEAIM KMAGIEKPAP SLHERQILEK
FDRIFNPEKF IEAVAEAEDF QVELGENFFD AEDDETFGSI AHMYNIRARL NKIKEMFYVS
KARCNNSLQK MWKSAKACIT AAENKLITIA QFFLSFFSNT AQKFINYLPS VPTSDILVGI
CSTAAALFGV WYTGIFRSKS ADSSSAWCQF NRSPSDATAP CDRCASCKIL QYPKHGNMLV
HFLERTGIKS VRNDLLKQGI SRDDLENVRE EVRISLQRPV ANTVVRQCRL QQLVDSGFRA
TNVAEAHTIV SAPCWYDCTF CESYEEESGR FDLNNGRNLI DQTNNFLDLV AEQQAAAQGV
YDTQPRVSRP VNYAQRIYET QPAVPKQRQF AQRVYESNPR VPRARRLAQG LVDCLPNTEM
HLGARRYTYA QRDRVQIEQT TQVLLNNSVW IQAVDKNGMC CRSNGVFLVG RTMITTAHTI
MNPPHIDPIE YLVIQNPYST ERAIEIPIDQ CKISQAFQID GSPVDLALVS FPPVVPNRQR
ILSKFLNAGD IDLLKEGDLT FSGFYQHGNK TIVQEKYPQS FTVSTKTTEY FLHAPGTCPK
DPTRCVCPIK IGNHIDYDLE TSNGMCGALL SISNKLIHTK LIGFHVAGGA GVLALGVLTT
RQFLEKALSE HIERFKIPKS YLIDGRLPYS QSWVDTTKQV SLIELGDCLN VGTAPAPAAP
STTQLAPSMV FDKIQQHIAK PAYLRPVEVE GEGLVDPMLK GIKKIMGRQT FVDPDLLEAA
ANDVFQGLGT PIGGKGVVHS YEQAITGVDG DPYKRPINRT TSPGYPYNLT NKTKGKTAWL
GDGEEYIVDN PELRKDVESL ISDSRKGIRG NAISIATLKD EKRPIAKVDA GKTRVFEACP
QHLVIAIRQY FLDFAAHVMR NRIDNGIAVG INPYSLEWTK LAHHLQSKGN YMIAGDFSNF
DGSLLMQVLV KIVEKINDWY GDSEENQLIR AALWEHICNA DILVRGEVIR KTHSQPSGNP
LTVIINSLFN GIVMRIAYML LKKEQGLPAT CDYRKYVSEI IYGDDDIKSV STEITHWFNQ
LTLTDALASF GLTYTDETKT GKILPFKPLE DVAFLKRKFV IQKDGTFLAP MDLTNTLEIT
NWIRGKAKRT ATIENCEQTI MELSLHPQEV YEYWSTRIRE ELAAVGLSIQ VPTYYEQMET
YRYNRDMYAR TEYVPLW
//
