ID   A0A1L3KMK2_9VIRU        Unreviewed;      1607 AA.
AC   A0A1L3KMK2;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0008006|Google:ProtNLM};
OS   Wenzhou picorna-like virus 14.
OC   Viruses; Riboviria.
OX   NCBI_TaxID=1923598 {ECO:0000313|EMBL:APG78593.1};
RN   [1] {ECO:0000313|EMBL:APG78593.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WZSLuoII97619 {ECO:0000313|EMBL:APG78593.1};
RX   PubMed=27880757; DOI=.1038/nature20167;
RA   Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA   Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT   "Redefining the invertebrate RNA virosphere.";
RL   Nature 540:539-543(2016).
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DR   EMBL; KX884382; APG78593.1; -; Genomic_RNA.
DR   RefSeq; YP_009337718.1; NC_033223.1.
DR   GeneID; 30855330; -.
DR   KEGG; vg:30855330; -.
DR   Proteomes; UP000203022; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   CDD; cd23195; Marnaviridae_RdRp; 1.
DR   Gene3D; 1.20.960.20; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR   InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR   InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF00680; RdRP_1; 1.
DR   Pfam; PF00910; RNA_helicase; 1.
DR   PRINTS; PR00918; CALICVIRUSNS.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR   PROSITE; PS51218; SF3_HELICASE_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000203022};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          307..489
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51218"
FT   DOMAIN          1328..1461
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50507"
SQ   SEQUENCE   1607 AA;  183877 MW;  89A7A7BEB5549B8E CRC64;
     MLNSLRLYCY YGTQQTPALL ALRSGYLAQS PDSDLFSDIF NIPNLIRLAW NGRGMSDPVE
     TVLYCIESTI SLVFKLGRSR SPLDAIIYCM DYIRTITKQS ITKSILQSSL MSRFKKLFSD
     FTFPEAIPMD SFRTQAPAIS WLRFGIDSLD GILDNYQSVS SCDIVVRFKK FILYSLCLYS
     TETMKLQFSE KLFTRIERNQ AIFNTEDKPM SMMLDVLRNF TYFLKHGLAV METGDWSLMW
     LSSDKIAKLH NEYIFLMSNF TPFITGNLKE CDTHSYMQRL DTNIEAIKRT INACKQSKLK
     SVDLSYLRKM HSELSAKQAD IYTEQFARES RDPPFGICIL GPPGVGKSSL IDVFGKCFAS
     KKGKQYDNTI KYTKNPTANF WDGYRTSQWM IVLDDVGFLD PRKAPNGDPT LMEILQIHNT
     TAFVPDQASL DLKGKTPCRC ELLVATSNTK DLNAEKYFQT PSAVLRRFDI NIEVSVKPAF
     ATEDGRLDHV RIKELNALRE RDGLKPLSDI YWNVNVFRYL ILPENRFERK VIFEGSIEDF
     LRHDDGMDKI LDNHISALNL RKANEKIREK VCVCKHVLEN GKFCNLLSNM CEHDYVEEVS
     DKDAEDEKPS FRRLKEIVSA HYEGFSSHVK KNVLAHFKTP DELNSVLESK GCKPITAFSS
     QAPELCDTDT EEFVDEEEMP VEFDRYDDYE LEQLEKDFIS KEKKLRNLKT QIYHTRNVHR
     VWPSLWQNHL DDLNERRIKC QHEIDTHIFR QYTVYKAVKD HRKSIVLKSA GVVAGVLSLV
     AAVTLAYKLY VSKSQAPKPI PSDSKVNPWK QQAEKVPYPA YMDTNTLSDR LSRNVGVIKI
     HVDDTKSEYI VVGALCVRGT YWVTTKHAFR RAKFISLVTQ NNKQGVTSNT QPIRYVESQH
     IVDDSRDLII LNFVQSRPCR SLYHLLPKED LFDINSDGRI LFKEEDGSSR DIEVTDIRKC
     GRPHTYSQGV FSPSYSVGEN DITYKGENFE GLCGFPIISE VDSLTRNRKA SKKIIIAGIH
     TAGSYFSSLG RVISRDWLDA TLPPLDEFCI QSASDDVEPI GYPEKEVALD DIHPKSPFNF
     LPSGQAELYG RLDYPRSTPR SSVGKTIMAD SVVKHCGVEI THSAPDMTSW RPMYHAAKDL
     VNPVQHLDSS IIKLCAYTYF RDISDRIKNP SDIEKYDMDT IVNGAPGVKF VDKMNFKTSM
     GFPFRGPKSK FLHPHPYKPF TDFKVFDEKV LDMVVEYEEN LAEGKRSGAV FTAHLKDEPR
     SLKKVAEGKT RVFTGANVAF TILLRKYFLS VTRLLQNNWQ AYNGAVGVNC FSTEWGDFYN
     YLTVYGSDRI VAGDYKAFDK RMPPLIILWA FEILIHLNKE LGDFSMTDIK IMRGLATDVA
     YPRVNFGGEL VEFVGGNPSG HALTVVINSL ANCLYMRYCF HVLAHEHKVP DICQQFSTYV
     NLLTYGDDNI MGVSPDVPFF NHSSISKVLS DVDITYTMAE KDQESVPYIS INDASFLKRK
     WKMIGGLWAC PLDETSIFRS LMLRLYDSSI GSRAHAKQVL DNACRELSLY GQEHYNQRIE
     QLKKVNSECK LRFEFYTWEE AFQKVYMSIC DETALDDDEL VEFFAQA
//