ID A0A1L3KNP1_9VIRU Unreviewed; 1741 AA.
AC A0A1L3KNP1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=RNA-directed RNA polymerase {ECO:0008006|Google:ProtNLM};
OS Changjiang picorna-like virus 12.
OC Viruses; Riboviria.
OX NCBI_TaxID=1922785 {ECO:0000313|EMBL:APG78998.1};
RN [1] {ECO:0000313|EMBL:APG78998.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJLX29956 {ECO:0000313|EMBL:APG78998.1};
RX PubMed=27880757; DOI=.1038/nature20167;
RA Shi M., Lin X.D., Tian J.H., Chen L.J., Chen X., Li C.X., Qin X.C., Li J.,
RA Cao J.P., Eden J.S., Buchmann J., Wang W., Xu J., Holmes E.C., Zhang Y.Z.;
RT "Redefining the invertebrate RNA virosphere.";
RL Nature 540:539-543(2016).
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DR EMBL; KX884545; APG78998.1; -; Genomic_RNA.
DR RefSeq; YP_009336581.1; NC_032779.1.
DR GeneID; 30853829; -.
DR KEGG; vg:30853829; -.
DR Proteomes; UP000203432; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23194; Dicistroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000203432};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 459..639
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 938..1184
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1467..1595
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 1741 AA; 198597 MW; 55BEA004FD109BF7 CRC64;
MNKNNEFKIC EVDGYPQQPS ALIEQNLFNY FSKEITDKLK DYKQAILARD RLQTQLLGFE
IRDLVAHVRR ALKINTKTAL LRLNLVKDDS LHGIFASDFV AYDSKWNKPL FNKLSPKRLV
DVSSAQREDK TTKKQIQLSI QQQRKLKRNL FGGDSVISQG LWSSTEKVED ALDSVQDLSD
KLMSIVDETD DKALPSLLSK LNVLVENANS QIQDLNVKQV FDSIMESQAQ LTSASVKAQD
IFKRISDLFP GIAFGSAVII VVICAYYYVR TNEAKYYWYF CCASFFLGHC IGAEIGTWIM
RMAREPTGVQ TQGPSEAIGK FANLAIAGLH IGNADKGKLD KFVSFLTNSE RRSQTITDIM
DYMYEVLIHV ANIFLSMFGY DKIYSFKKGE DERADSIFGI YENIMKRIDD ELYEHNEASY
KEIVDLCDMC TEYLRNTRET ASNRSLVHQV RGIYSFCLNK RMAMAESHWK HTGYRPEPVC
LVLVGEPGVG KTQNVEYISA AYCAKTLPAS EQETLLTKGT APYVYIRHDE LEFWEGYKNK
HVVTVIDDLG QRRTSVGDAD SFIEVIRIIN SFPYHLHMAE LTKKENTFFT SRLLIVTSNM
TKFQPVTLYS SDAIARRLRF KFRVKVKEEY AAENGEIDPL KLPRDANGVG VFDPREVNYY
ISIDDEGNAV ERNGRTTHTF EQLMDMTLAQ SSFKDQQRQT KQERVNDMIR DILGVKKTED
LTPIVQQSGD NILFAETKRR SVEDPFERFI EQYYTKMFDQ KDLNVAAVTL TATEMISDQF
IIKANLVRYY DEHNTLDGFC YYFHTRDFVH DWWMKKHHGM FSRFTEFLRS KLQQPWLLNL
IEWVHNRPAL LAWLSILQKV LIALGILGVA GTLGFTAYGK IVEYTSFDPE TISDAELQKI
SSDHAAYFDG ALPQSTHVRV GRGTRKYNVK VKAAVKQGGS FVTDVLNVVK ANLYEFYIQK
KWTTINVESM MEAELVDFSK FGTVLFTHGR NVLTPFHFVT AVIDLLDDIK GTEGQMPYVV
FSPIGGSTRK RIFVSCDKFL EGILYLPRTT SDEEMYYEDY SVVELPKFVP CQRDIRKHFI
TDTETFDSPD VALICATKGD TTIVHGKGIA LSKEKPCLVT SPSSPPTALE SGWAYRIPTV
AGDCGGVVVL SAGSRSRTVI GGIHVGGSTA RGLGFSQKIP QSALLRFQSD HDSLDSRFEQ
LEVAQPDQAL DAVVQQGNFQ VRGRVAKCHN PYGKSKIGKS LVHSDRCQSY FDSRMAPSFL
RPDAKNDPFS RALTAYCANP SFDISDECFE RAYTEVKSHM LRFNAEPRVY TFEEAVRGVS
DHAYFKSLNR AASAGYPYSL EGITKKMIFG DGQEYTFHTP LAKKVRLNCE QIIHKAKNGQ
REFHVYTDNL KDETLPKEKV DIHKTRLFCG SPLDYTIVVR MYFGDFMAYV QRHCIDLGMA
IGVNPMSNDW HLIALQLLQK GGSADNARFG AGDYKRFDGS EISFVHWRIL DIINAYYGDD
EVGTQVRTIL WYDLVNSNHI MGTTIYTWNN SLPSGHPLTS IVNSLYNHLA MCYCYYSIQR
EMDYQLRGTF YDNVYLVVMG DDNLFGDTYE ASLFFTESNI AQHMTKLGLT YTSDTKDGIN
VSLRTLHDVS FLKRKFRMER DMSASGIFGL WCAPLQLEVV LETPMWFTKS KESHVDILKS
NIESSLRELS LHGRSVFELW APKLRETYYR EMRQNAYIAP PLLHIEYEEA RYAVASLDVM
Y
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