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Database: UniProt
Entry: A0A1L3L2W2_9RHIZ
LinkDB: A0A1L3L2W2_9RHIZ
Original site: A0A1L3L2W2_9RHIZ 
ID   A0A1L3L2W2_9RHIZ        Unreviewed;       440 AA.
AC   A0A1L3L2W2;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   10-APR-2019, entry version 10.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   Name=thrA {ECO:0000313|EMBL:APG84439.1};
GN   ORFNames=SAMCCGM7_Ch1681 {ECO:0000313|EMBL:APG84439.1};
OS   Sinorhizobium americanum CCGM7.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=1408224 {ECO:0000313|EMBL:APG84439.1, ECO:0000313|Proteomes:UP000027923};
RN   [1] {ECO:0000313|EMBL:APG84439.1, ECO:0000313|Proteomes:UP000027923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCGM7 {ECO:0000313|EMBL:APG84439.1,
RC   ECO:0000313|Proteomes:UP000027923};
RA   Peralta H., Aguilar-Vera A., Diaz R., Mora Y., Martinez-Batallar G.,
RA   Salazar E., Vargas-Lagunas C., Encarnacion S., Girard L., Mora J.;
RT   "Genomic differences between typical nodule nitrogen-fixing rhizobial
RT   strains and those coming from bean seeds.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CP013051; APG84439.1; -; Genomic_DNA.
DR   RefSeq; WP_037384462.1; NZ_CP013051.1.
DR   STRING; 1408224.SAMCCGM7_c3539; -.
DR   OrthoDB; 1464088at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000027923; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027923};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:APG84439.1};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      355    439       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    207    207       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     107    107       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     192    192       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   440 AA;  46776 MW;  6247904A276A9965 CRC64;
     MADALKIGVA GLGTVGASLV RILQERHEML ATTCGRPIEL IAVAARDRTK DRGIDLSKAV
     WFEDAVALAS EAEIDVFVEL MGGAGDPAYS SVKAALERGI HVVTANKALL AKHGIELAGI
     AEEQGALLNY EAAVAGGIPV IKALRESLTG NTVSRVYGIM NGTCNYILTK MEKEGLTFKA
     CLEEAQRLGY AEADPTFDIE GNDTAHKLSI LTSLAFGTAI AADDIYLEGI TNISIEDIQA
     AADLGYRIKL LGVAQRTDSG IEQRVHPTMV PHDSVIAQVD GVTNAVAVES DILGELLMVG
     PGAGGNATAS AVLGDIADIA KSRPGAQHVP AFGRPTTALM PYKRARMQSH EGGYFIRLKV
     VDRTGVFANI AGHMAENDIS LESIMQHSKH YADPAEPKTI ILVTHATHEA SVRKAIVSIK
     SEGYLVGEPQ VIRIERPKDW
//
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