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Database: UniProt
Entry: A0A1L3MEP9_9MICO
LinkDB: A0A1L3MEP9_9MICO
Original site: A0A1L3MEP9_9MICO 
ID   A0A1L3MEP9_9MICO        Unreviewed;       440 AA.
AC   A0A1L3MEP9;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=ASJ30_04165 {ECO:0000313|EMBL:APH00825.1};
OS   Janibacter indicus.
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Janibacter.
OX   NCBI_TaxID=857417 {ECO:0000313|EMBL:APH00825.1, ECO:0000313|Proteomes:UP000182938};
RN   [1] {ECO:0000313|EMBL:APH00825.1, ECO:0000313|Proteomes:UP000182938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YFY001 {ECO:0000313|EMBL:APH00825.1,
RC   ECO:0000313|Proteomes:UP000182938};
RA   Zhang Y., Guo Z.;
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CP013290; APH00825.1; -; Genomic_DNA.
DR   RefSeq; WP_072623987.1; NZ_CP013290.1.
DR   KEGG; jte:ASJ30_04165; -.
DR   KO; K00003; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000182938; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000182938};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182938};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      358    436       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      14     21       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    209    209       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     109    109       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     194    194       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   440 AA;  45341 MW;  0A5809EBC2DD35EA CRC64;
     MTTDQQTPLR VALLGGGVVG GSVARQLITQ ADDLAQRIGR PLELVGIAVR RAGRDRSDLG
     VDPALFTTDA AELVTRADIV VEVIGGIEPA RSLILSAMEH GASVVTANKA LLAEDGPTLY
     AAAADHGVDL YYEGAVAGAI PILRPIRDSL AGDSIRRVIG IVNGTTNFVL DAMDSTGAGF
     SETVERAQAL GYAEADPTAD VEGFDAAAKA AILSSLAFHS RVSSADVHRE GITEVSARDI
     AAAREMNCTV KLLAICERVE GPEGQPGISA RVHPALIPLT HPLASVREAY NAVFVEADGA
     GDLMFYGQGA GGDPTASAVL GDIVAVARTR VTGGRGPGES AYADLPVLSI GQAITRYHVS
     LDVADKPGVL ASVATVFATQ GVSIETVRQQ VVTDDHGDAR AMLIIVTHAA TDAALSATVT
     ELAGLDTVNE VTSVMRVEGN
//
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