ID A0A1L4BSU1_9GAMM Unreviewed; 462 AA.
AC A0A1L4BSU1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN ORFNames=F7310_05775 {ECO:0000313|EMBL:API86894.1};
OS Francisella uliginis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=573570 {ECO:0000313|EMBL:API86894.1, ECO:0000313|Proteomes:UP000184222};
RN [1] {ECO:0000313|EMBL:API86894.1, ECO:0000313|Proteomes:UP000184222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX077310 {ECO:0000313|EMBL:API86894.1,
RC ECO:0000313|Proteomes:UP000184222};
RX PubMed=27881415;
RA Challacombe J.F., Petersen J.M., Gallegos-Graves V., Hodge D., Pillai S.,
RA Kuske C.R.;
RT "Whole genome relationships among Francisella bacteria of diverse origin
RT define new species and provide specific regions for detection.";
RL Appl. Environ. Microbiol. 0:0-0(2016).
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity and contains
CC distinct active sites for ATP binding, DNA binding, and interaction
CC with DnaC protein, primase, and other prepriming proteins.
CC {ECO:0000256|ARBA:ARBA00003574, ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR EMBL; CP016796; API86894.1; -; Genomic_DNA.
DR RefSeq; WP_072712447.1; NZ_CP016796.1.
DR AlphaFoldDB; A0A1L4BSU1; -.
DR STRING; 573570.F7310_05775; -.
DR KEGG; frx:F7310_05775; -.
DR Proteomes; UP000184222; Chromosome.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU362085};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085};
KW Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|RuleBase:RU362085}.
FT DOMAIN 182..450
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
SQ SEQUENCE 462 AA; 51665 MW; 6AEC30C547FBBE0B CRC64;
MDYQFKAAET TYSIEAEKAI LGNILLNNQN IELVEDLLLI EDFFDKRHRI IYKQINILNQ
ANTPFDVLIL SEYLATEGLL EEAGGEVYIV DLAANTPSVS NIKIYANIVK DKAKLRSLQS
SVNDIVQKIY SADSKNPDEV IDYAESRILD IAKERETLTK GPESIKSVIP KLVDRMSAIV
DAGTGLTGAS TGFIDLDKMT SGLQRANLGI IAARPSMGKT VLGINIAQNV AKISEKPVLV
FSLEMPSEDI VTRMLASQAR VEMNLLKECN RLNDAHWVKI TKAMKDLSDM PLYIDDTSSL
TPAEMRSRAR RLYNEHDGLS MILIDYLQLM KIPGYETNRT LEVSEISRSL KALAKELDIP
VIALSQLNRA VDDRKDKRPM MSDLRESGAI EQDADLIMFI YRDEVYNKDK EDNKNLGEII
IGKQRNGPIG AVHVRFDGQF ASFANLTNEN DNILPGDIGY NE
//
