ID   A0A1L4BU10_9GAMM        Unreviewed;      1159 AA.
AC   A0A1L4BU10;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=F7310_08125 {ECO:0000313|EMBL:API87333.1};
OS   Francisella uliginis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=573570 {ECO:0000313|EMBL:API87333.1, ECO:0000313|Proteomes:UP000184222};
RN   [1] {ECO:0000313|EMBL:API87333.1, ECO:0000313|Proteomes:UP000184222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TX077310 {ECO:0000313|EMBL:API87333.1,
RC   ECO:0000313|Proteomes:UP000184222};
RX   PubMed=27881415;
RA   Challacombe J.F., Petersen J.M., Gallegos-Graves V., Hodge D., Pillai S.,
RA   Kuske C.R.;
RT   "Whole genome relationships among Francisella bacteria of diverse origin
RT   define new species and provide specific regions for detection.";
RL   Appl. Environ. Microbiol. 0:0-0(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; CP016796; API87333.1; -; Genomic_DNA.
DR   RefSeq; WP_072713120.1; NZ_CP016796.1.
DR   AlphaFoldDB; A0A1L4BU10; -.
DR   STRING; 573570.F7310_08125; -.
DR   KEGG; frx:F7310_08125; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000184222; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          3..70
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1159 AA;  129649 MW;  46ABC1F9F21B1831 CRC64;
     MISHLRVHTG FSVVDSTVRL GDLFSRAKDK DIAAIALTDV CNLFAAVKFY KQALGSGVKP
     IFGVELKIDT ELGVSDLILL AEDNDGYQNI VDLVSKAYQE ADRVGSIPLI PKSWLKESNL
     ENVICLNGGQ HGELGKAILA KDDTKVQEII AEDIAIFGQD NYVIEIHKLE YENEGLYNEK
     ALELATKHNL IAVVTNLTVF MESDDYDIHE IRACINEKTT ILDESRKSRF TRQQYLKSAD
     EMYETFNSLS VLVDNTLAIA KRCNVTFDLG KPCLPTVDIP DGLTEKEYFS KLCYQGLENR
     LEKVLANKPQ DKHDHIIKVY KDRLQREIDI ICDMGFPGYF LIVEDFIRWS KENDIPVGPG
     RGSGAGSLVA YSLLITDIDP LPYGLLFERF LNPERVSMPD FDIDFCIQGR DRVIKYVEQK
     YGKQSVGQII TYGTMAAKGV VRDVVRVMGQ SFGFGDRIAK LIPETPGTTF KKILHEGEPL
     YDEMQADEDV AEIVEKAQKL EGLPRSLGKH AAGIVISPTV ISDFAPIYCE DKGGDIVTQF
     DKGDVEDVGL VKFDFLGLKN LTIIKNAIAS INAKRPSDEI PLNISDIPLD DEKTFKLLQA
     GNTTGIFQLE SQGMRQIVKD LGTSNFEEII ALVALYRPGP MENIPTFIDR KHGRKRTTYL
     HPLLEEVLRE TYGIPVYQEQ VMQMAQKLAG YTLGAADLLR RAMGKKKPEE MEQQRKIFKE
     GAAKYHNIEA GLADEIFDQM EAFAGYGFNK SHAAAYALIA YQTAWLKAHY PDEYMAALMS
     GDMGNTDQLV KFILDCKNMG ITVLSPNVNK SVYDCIAISK GTILLGLGAI KGLGGEAIKS
     ILTERDAEGE FSSIFDLTRR VDLRKVNKKA LEALCFAGAI KDISRNRATA FNSIEKAIKN
     AGYVNEMAAA GQNDLFGFTE QESDTDNELE RECISEEWSL KELLINEKKA LGMYFSGHII
     DEESHWRNHV SFSDLQKIQQ PNMDGNSVRI IASMITPAIR RKTKTGRILY IINIDDEFDR
     ADCLVGEDVF ALVKDNIQVD DIVVVEGKVS RDVQRECNKL SVDKVQPISQ YIDENFSKVE
     LNLRSKNVNP TNLKKVLDNL KTNIASTDIH KENVLEITVS LDDVEGKFDY LQKPFSIYKF
     VNDISRLIAE GSTVSLSGV
//