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Database: UniProt
Entry: A0A1L6FGY6_9RHOO
LinkDB: A0A1L6FGY6_9RHOO
Original site: A0A1L6FGY6_9RHOO 
ID   A0A1L6FGY6_9RHOO        Unreviewed;       357 AA.
AC   A0A1L6FGY6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=Tchl_3297 {ECO:0000313|EMBL:APR06103.1};
OS   Thauera chlorobenzoica.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Zoogloeaceae; Thauera.
OX   NCBI_TaxID=96773 {ECO:0000313|EMBL:APR06103.1, ECO:0000313|Proteomes:UP000185739};
RN   [1] {ECO:0000313|EMBL:APR06103.1, ECO:0000313|Proteomes:UP000185739}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3CB1 {ECO:0000313|EMBL:APR06103.1,
RC   ECO:0000313|Proteomes:UP000185739};
RA   Goris T., Mergelsberg M., Boll M.;
RT   "Complete genome sequence of Thauera chlorobenzoica, a
RT   Betaproteobacterium degrading haloaromatics anaerobically to CO2 and
RT   halides.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP018839; APR06103.1; -; Genomic_DNA.
DR   KEGG; tcl:Tchl_3297; -.
DR   KO; K01626; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000185739; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000185739};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185739};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:APR06103.1}.
FT   DOMAIN       38    337       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   357 AA;  39316 MW;  FA368DEA417017BE CRC64;
     MKIHIDDVRI QEIKELVPPV HVLREFPATP KAAAVAYEAR QGIHRILYGA DDRLLVVIGP
     CSIHDAAAAI DYANKLKVEA DRLKDDLLVV MRVYFEKPRT TVGWKGLIND PYLDNSFRIN
     EGVRLARKLL WEINELGLPA GTEFLDMITP QYIADLIAWG AIGARTTESQ VHRELASGLS
     CPVGFKNGTD GNLRIAVDAI KAAQAPHHFL SVTKAGHSAI VSTRGNEDCH VILRGGKEPN
     YDAASVDVAS KELAAASVCS KVMIDFSHAN SRKQHRLQIE VAKDTAAQMA AGDERIMGVM
     VESHLKEGRQ DLMPGKELEY GKSITDACIG WEDSVQVLDI LAEAVRQRRV KRAAEFE
//
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