ID A0A1L6J8V9_9SPHN Unreviewed; 221 AA.
AC A0A1L6J8V9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Phosphoribosylformylglycinamidine synthase subunit PurQ {ECO:0000256|HAMAP-Rule:MF_00421};
DE Short=FGAM synthase {ECO:0000256|HAMAP-Rule:MF_00421};
DE EC=6.3.5.3 {ECO:0000256|HAMAP-Rule:MF_00421};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase subunit I {ECO:0000256|HAMAP-Rule:MF_00421};
DE Short=FGAR amidotransferase I {ECO:0000256|HAMAP-Rule:MF_00421};
DE Short=FGAR-AT I {ECO:0000256|HAMAP-Rule:MF_00421};
DE AltName: Full=Glutaminase PurQ {ECO:0000256|HAMAP-Rule:MF_00421};
DE EC=3.5.1.2 {ECO:0000256|HAMAP-Rule:MF_00421};
DE AltName: Full=Phosphoribosylformylglycinamidine synthase subunit I {ECO:0000256|HAMAP-Rule:MF_00421};
GN Name=purQ {ECO:0000256|HAMAP-Rule:MF_00421};
GN ORFNames=BDW16_1529 {ECO:0000313|EMBL:PJI88264.1}, BRX38_08535
GN {ECO:0000313|EMBL:RSU41916.1}, BRX39_16415
GN {ECO:0000313|EMBL:RSU32376.1}, BRX40_07470
GN {ECO:0000313|EMBL:APR52287.1}, CA221_09875
GN {ECO:0000313|EMBL:RSU50809.1}, CA222_10040
GN {ECO:0000313|EMBL:RSU26607.1}, CA223_13075
GN {ECO:0000313|EMBL:RSU38680.1}, CA224_12325
GN {ECO:0000313|EMBL:RSU19819.1}, CA225_11725
GN {ECO:0000313|EMBL:RSU27388.1}, CA226_15205
GN {ECO:0000313|EMBL:RSV62467.1}, CA227_13030
GN {ECO:0000313|EMBL:RSX12094.1}, CA228_17175
GN {ECO:0000313|EMBL:RSV54380.1}, CA229_17325
GN {ECO:0000313|EMBL:RSV53095.1}, CA230_17495
GN {ECO:0000313|EMBL:RSW92420.1}, CA231_19695
GN {ECO:0000313|EMBL:RSV42977.1}, CA232_16495
GN {ECO:0000313|EMBL:RSV34755.1}, CA238_12035
GN {ECO:0000313|EMBL:RSV24106.1}, CA239_17590
GN {ECO:0000313|EMBL:RSV25113.1}, CA240_12810
GN {ECO:0000313|EMBL:RSV06032.1}, CA242_10755
GN {ECO:0000313|EMBL:RSV09429.1}, CA253_16585
GN {ECO:0000313|EMBL:RSU86642.1}, CA256_07635
GN {ECO:0000313|EMBL:RSU96335.1}, CA257_15900
GN {ECO:0000313|EMBL:RSV00921.1}, DAH52_19425
GN {ECO:0000313|EMBL:RSU91327.1}, DAH53_11640
GN {ECO:0000313|EMBL:RSU80421.1}, DAH54_17325
GN {ECO:0000313|EMBL:RSU76875.1}, DAH55_16730
GN {ECO:0000313|EMBL:RSU65758.1}, DAH56_17105
GN {ECO:0000313|EMBL:RSU57643.1}, DAH57_18685
GN {ECO:0000313|EMBL:RSZ18756.1}, DAH58_06355
GN {ECO:0000313|EMBL:RSZ16279.1}, DAH59_05245
GN {ECO:0000313|EMBL:RSZ01127.1}, DAH60_11100
GN {ECO:0000313|EMBL:RSZ10733.1}, DAH61_13910
GN {ECO:0000313|EMBL:RSY98186.1}, DAH62_12170
GN {ECO:0000313|EMBL:RSY94568.1}, DAH63_10150
GN {ECO:0000313|EMBL:RSZ09687.1}, DAH64_12625
GN {ECO:0000313|EMBL:RSY81846.1}, DAH65_12040
GN {ECO:0000313|EMBL:RSY84812.1}, DAH66_15665
GN {ECO:0000313|EMBL:RSY80607.1}, DAH67_12720
GN {ECO:0000313|EMBL:RSY70778.1}, DAH68_08250
GN {ECO:0000313|EMBL:RSY71458.1}, DAH69_09985
GN {ECO:0000313|EMBL:RSY61706.1}, DAH70_11070
GN {ECO:0000313|EMBL:RSY55953.1}, DAH71_02450
GN {ECO:0000313|EMBL:RSY56679.1}, DAH72_14645
GN {ECO:0000313|EMBL:RSY63748.1}, DAH73_13610
GN {ECO:0000313|EMBL:RSY33131.1}, DAH74_14300
GN {ECO:0000313|EMBL:RSY44133.1}, DAH75_12380
GN {ECO:0000313|EMBL:RSY37629.1}, DAH76_11120
GN {ECO:0000313|EMBL:RSY43705.1}, DAH77_18920
GN {ECO:0000313|EMBL:RSY20183.1}, DAH78_08655
GN {ECO:0000313|EMBL:RSY12741.1}, DAH79_10760
GN {ECO:0000313|EMBL:RSY27765.1}, DAH80_10915
GN {ECO:0000313|EMBL:RSY20343.1}, DAH81_12830
GN {ECO:0000313|EMBL:RSY12565.1}, DAH82_10230
GN {ECO:0000313|EMBL:RSY00948.1}, DAH83_07510
GN {ECO:0000313|EMBL:RSY07130.1}, DAH84_06985
GN {ECO:0000313|EMBL:RSX83770.1}, DAH85_11905
GN {ECO:0000313|EMBL:RSX90813.1}, DAH86_18245
GN {ECO:0000313|EMBL:RSX84025.1}, DAH87_03025
GN {ECO:0000313|EMBL:RSX99798.1}, DAH88_06975
GN {ECO:0000313|EMBL:RSX66522.1}, DAH89_10555
GN {ECO:0000313|EMBL:RSX73658.1}, DAH90_07800
GN {ECO:0000313|EMBL:RSX79636.1}, DAH91_06055
GN {ECO:0000313|EMBL:RSX63542.1}, DAH92_09545
GN {ECO:0000313|EMBL:RSX69212.1}, DAH93_06315
GN {ECO:0000313|EMBL:RSX46905.1}, DAH94_08720
GN {ECO:0000313|EMBL:RSX42428.1}, DAH95_10625
GN {ECO:0000313|EMBL:RSX37683.1}, DAH96_00330
GN {ECO:0000313|EMBL:RSX22838.1}, DAH97_03705
GN {ECO:0000313|EMBL:RSX33982.1}, DAH98_11060
GN {ECO:0000313|EMBL:RSX27275.1}, DAH99_11365
GN {ECO:0000313|EMBL:RSX23702.1}, DAI00_12465
GN {ECO:0000313|EMBL:RSX08022.1}, DAI01_12740
GN {ECO:0000313|EMBL:RSX05655.1};
OS Sphingomonas koreensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=93064 {ECO:0000313|EMBL:APR52287.1, ECO:0000313|Proteomes:UP000185161};
RN [1] {ECO:0000313|EMBL:APR52287.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ABOJV {ECO:0000313|EMBL:APR52287.1};
RA Conlan S., Thomas P.J., Mullikin J., Palmore T.N., Frank K.M., Segre J.A.;
RT "Whole genome sequencing of Sphingomonas koreensis.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000185161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ABOJV {ECO:0000313|Proteomes:UP000185161};
RA Conlan S., Thomas P.J., Mullikin J., Palmore T.N., Frank K.M., Segre J.A.;
RT "Whole genome sequencing of Sphingomonas sp. ABOJV.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000228629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSS26 {ECO:0000313|Proteomes:UP000228629};
RA Blow M.;
RT "Pac Bio to generate improved reference genome sequences for organisms with
RT transposon mutant libraries (support for FEBA project).";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:PJI88264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JSS26 {ECO:0000313|EMBL:PJI88264.1};
RA Han C.G.;
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:PJI88264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JSS26 {ECO:0000313|EMBL:PJI88264.1};
RX PubMed=29769716; DOI=10.1038/s41586-018-0124-0;
RA Price M.N., Wetmore K.M., Waters R.J., Callaghan M., Ray J., Liu H.,
RA Kuehl J.V., Melnyk R.A., Lamson J.S., Suh Y., Carlson H.K., Esquivel Z.,
RA Sadeeshkumar H., Chakraborty R., Zane G.M., Rubin B.E., Wall J.D.,
RA Visel A., Bristow J., Blow M.J., Arkin A.P., Deutschbauer A.M.;
RT "Mutant phenotypes for thousands of bacterial genes of unknown function.";
RL Nature 557:503-509(2018).
RN [6] {ECO:0000313|Proteomes:UP000286970, ECO:0000313|Proteomes:UP000287271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-NIH.Env2_1116 {ECO:0000313|EMBL:RSU26607.1,
RC ECO:0000313|Proteomes:UP000286970}, SK-NIH.Env3_1116
RC {ECO:0000313|EMBL:RSU38680.1, ECO:0000313|Proteomes:UP000287271},
RC SK-NIH.Env4_1116 {ECO:0000313|EMBL:RSU19819.1,
RC ECO:0000313|Proteomes:UP000287347}, SK-NIH.Env8_1116
RC {ECO:0000313|EMBL:RSU27388.1, ECO:0000313|Proteomes:UP000287976},
RC SK-NIH.Pt2_0716 {ECO:0000313|EMBL:RSU41916.1,
RC ECO:0000313|Proteomes:UP000287307}, SK-NIH.Pt4_0816
RC {ECO:0000313|EMBL:RSU32376.1, ECO:0000313|Proteomes:UP000287414}, and
RC SK-NIH.Pt6_1016 {ECO:0000313|EMBL:RSU50809.1,
RC ECO:0000313|Proteomes:UP000287315};
RA Johnson R.C., Deming C., Conlan S., Zellmer C., Michelin A., Lee-Lin S.-Q.,
RA Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P., Frank K.M.,
RA Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F., Palmore T.N.,
RA Segre J.A.;
RT "Genomic and Epidemiologic Investigation to Identify Sphingomonas koreensis
RT Point Sources in an Indolent Hospital Outbreak.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000286706, ECO:0000313|Proteomes:UP000286739}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-NIH.Env13_0417 {ECO:0000313|EMBL:RSZ16279.1,
RC ECO:0000313|Proteomes:UP000287513}, SK-NIH.Env14_0417
RC {ECO:0000313|EMBL:RSZ01127.1, ECO:0000313|Proteomes:UP000288569},
RC SK-NIH.Env16_0517 {ECO:0000313|EMBL:RSZ10733.1,
RC ECO:0000313|Proteomes:UP000287015}, SK-NIH.Env17_0517
RC {ECO:0000313|EMBL:RSZ18756.1, ECO:0000313|Proteomes:UP000287799},
RC SK-NIH.Env18_0517 {ECO:0000313|EMBL:RSY98186.1,
RC ECO:0000313|Proteomes:UP000288230}, SK-NIH.Env19_0617
RC {ECO:0000313|EMBL:RSY81846.1, ECO:0000313|Proteomes:UP000288258},
RC SK-NIH.Env20_0617 {ECO:0000313|EMBL:RSY84812.1,
RC ECO:0000313|Proteomes:UP000287482}, SK-NIH.Env21_0617
RC {ECO:0000313|EMBL:RSY94568.1, ECO:0000313|Proteomes:UP000287363},
RC SK-NIH.Env22_0617 {ECO:0000313|EMBL:RSZ09687.1,
RC ECO:0000313|Proteomes:UP000287001}, SK-NIH.Env23_0717
RC {ECO:0000313|EMBL:RSY70778.1, ECO:0000313|Proteomes:UP000287360},
RC SK-NIH.Env24_0717 {ECO:0000313|EMBL:RSY71458.1,
RC ECO:0000313|Proteomes:UP000287229}, SK-NIH.Env25_0717
RC {ECO:0000313|EMBL:RSY61706.1, ECO:0000313|Proteomes:UP000288269},
RC SK-NIH.Env26_0717 {ECO:0000313|EMBL:RSY55953.1,
RC ECO:0000313|Proteomes:UP000287417}, SK-NIH.Env27_0717
RC {ECO:0000313|EMBL:RSY56679.1, ECO:0000313|Proteomes:UP000286788},
RC SK-NIH.Env28_0717 {ECO:0000313|EMBL:RSY63748.1,
RC ECO:0000313|Proteomes:UP000288630}, SK-NIH.Env29_0717
RC {ECO:0000313|EMBL:RSY33131.1, ECO:0000313|Proteomes:UP000287038},
RC SK-NIH.Env30_0717 {ECO:0000313|EMBL:RSY44133.1,
RC ECO:0000313|Proteomes:UP000288207}, SK-NIH.Env31_0717
RC {ECO:0000313|EMBL:RSY37629.1, ECO:0000313|Proteomes:UP000287340},
RC SK-NIH.Env32_0717 {ECO:0000313|EMBL:RSY43705.1,
RC ECO:0000313|Proteomes:UP000288007}, SK-NIH.Env33_0717
RC {ECO:0000313|EMBL:RSY20183.1, ECO:0000313|Proteomes:UP000287541},
RC SK-NIH.Env34_0717 {ECO:0000313|EMBL:RSY12741.1,
RC ECO:0000313|Proteomes:UP000288649}, SK-NIH.Env35_0717
RC {ECO:0000313|EMBL:RSY27765.1, ECO:0000313|Proteomes:UP000287968},
RC SK-NIH.Env36_0717 {ECO:0000313|EMBL:RSY00948.1,
RC ECO:0000313|Proteomes:UP000288516}, SK-NIH.Env37_0717
RC {ECO:0000313|EMBL:RSY20343.1, ECO:0000313|Proteomes:UP000287028},
RC SK-NIH.Env38_0817 {ECO:0000313|EMBL:RSY12565.1,
RC ECO:0000313|Proteomes:UP000287257}, SK-NIH.Env39_0817
RC {ECO:0000313|EMBL:RSY07130.1, ECO:0000313|Proteomes:UP000287073},
RC SK-NIH.Env40_0817 {ECO:0000313|EMBL:RSX83770.1,
RC ECO:0000313|Proteomes:UP000288050}, SK-NIH.Env41_0817
RC {ECO:0000313|EMBL:RSX90813.1, ECO:0000313|Proteomes:UP000286739},
RC SK-NIH.Env42_0817 {ECO:0000313|EMBL:RSX84025.1,
RC ECO:0000313|Proteomes:UP000288181}, SK-NIH.Env43_0817
RC {ECO:0000313|EMBL:RSX99798.1, ECO:0000313|Proteomes:UP000286795},
RC SK-NIH.Env44_0817 {ECO:0000313|EMBL:RSX66522.1,
RC ECO:0000313|Proteomes:UP000286792}, SK-NIH.Env45_1017
RC {ECO:0000313|EMBL:RSX73658.1, ECO:0000313|Proteomes:UP000286760},
RC SK-NIH.Env46_1017 {ECO:0000313|EMBL:RSX69212.1,
RC ECO:0000313|Proteomes:UP000287577}, SK-NIH.Env47_1017
RC {ECO:0000313|EMBL:RSX46905.1, ECO:0000313|Proteomes:UP000288581},
RC SK-NIH.Env48_1017 {ECO:0000313|EMBL:RSX79636.1,
RC ECO:0000313|Proteomes:UP000287090}, SK-NIH.Env49_1017
RC {ECO:0000313|EMBL:RSX63542.1, ECO:0000313|Proteomes:UP000286744},
RC SK-NIH.Env50_1017 {ECO:0000313|EMBL:RSX42428.1,
RC ECO:0000313|Proteomes:UP000288198}, SK-NIH.Env51_1017
RC {ECO:0000313|EMBL:RSX37683.1, ECO:0000313|Proteomes:UP000287844},
RC SK-NIH.Env52_1017 {ECO:0000313|EMBL:RSX22838.1,
RC ECO:0000313|Proteomes:UP000287083}, SK-NIH.Env53_1017
RC {ECO:0000313|EMBL:RSX33982.1, ECO:0000313|Proteomes:UP000288435},
RC SK-NIH.Env54_1217 {ECO:0000313|EMBL:RSX23702.1,
RC ECO:0000313|Proteomes:UP000288203}, SK-NIH.Env55_1217
RC {ECO:0000313|EMBL:RSX08022.1, ECO:0000313|Proteomes:UP000286706},
RC SK-NIH.Env56_1217 {ECO:0000313|EMBL:RSX05655.1,
RC ECO:0000313|Proteomes:UP000287020}, and SK-NIH.Env57_1217
RC {ECO:0000313|EMBL:RSX27275.1, ECO:0000313|Proteomes:UP000287236};
RA Johnson R.C., Deming C., Conlan S., Zellmer C.J., Michelin A.V.,
RA Lee-Lin S.-Q., Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P.,
RA Frank K.M., Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F.,
RA Palmore T.N., Segre J.A.;
RT "Genomic and Epidemiologic Investigation of an Indolent Hospital
RT Outbreak.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000286681, ECO:0000313|Proteomes:UP000286696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 2882 {ECO:0000313|EMBL:RSU65758.1,
RC ECO:0000313|Proteomes:UP000286710}, KCTC 2883
RC {ECO:0000313|EMBL:RSU57643.1, ECO:0000313|Proteomes:UP000286956},
RC SK-CDC1_0717 {ECO:0000313|EMBL:RSY80607.1,
RC ECO:0000313|Proteomes:UP000287746}, SK-NIH.Env10_0317
RC {ECO:0000313|EMBL:RSV00921.1, ECO:0000313|Proteomes:UP000286681},
RC SK-NIH.Env11_0417 {ECO:0000313|EMBL:RSU76875.1,
RC ECO:0000313|Proteomes:UP000287165}, SK-NIH.Env12_0417
RC {ECO:0000313|EMBL:RSU91327.1, ECO:0000313|Proteomes:UP000288342},
RC SK-NIH.Env15_0417 {ECO:0000313|EMBL:RSU80421.1,
RC ECO:0000313|Proteomes:UP000288648}, SK-NIH.Env1_1016
RC {ECO:0000313|EMBL:RSV62467.1, ECO:0000313|Proteomes:UP000288283},
RC SK-NIH.Env5_1116 {ECO:0000313|EMBL:RSV54380.1,
RC ECO:0000313|Proteomes:UP000287812}, SK-NIH.Env7_1116
RC {ECO:0000313|EMBL:RSX12094.1, ECO:0000313|Proteomes:UP000288130},
RC SK-NIH.Env9_0217 {ECO:0000313|EMBL:RSU86642.1,
RC ECO:0000313|Proteomes:UP000287377}, SK-NIH.Pt10_0210
RC {ECO:0000313|EMBL:RSV09429.1, ECO:0000313|Proteomes:UP000288286},
RC SK-NIH.Pt11_0411 {ECO:0000313|EMBL:RSW92420.1,
RC ECO:0000313|Proteomes:UP000288535}, SK-NIH.Pt12_0112
RC {ECO:0000313|EMBL:RSV53095.1, ECO:0000313|Proteomes:UP000286696},
RC SK-NIH.Pt14_0612 {ECO:0000313|EMBL:RSV34755.1,
RC ECO:0000313|Proteomes:UP000287457}, SK-NIH.Pt16_1112
RC {ECO:0000313|EMBL:RSV42977.1, ECO:0000313|Proteomes:UP000287806},
RC SK-NIH.Pt7_0906 {ECO:0000313|EMBL:RSV24106.1,
RC ECO:0000313|Proteomes:UP000288528}, SK-NIH.Pt8_0208
RC {ECO:0000313|EMBL:RSV25113.1, ECO:0000313|Proteomes:UP000287886},
RC SK-NIH.Pt9_0208 {ECO:0000313|EMBL:RSV06032.1,
RC ECO:0000313|Proteomes:UP000287793}, and SK-NY1_0417
RC {ECO:0000313|EMBL:RSU96335.1, ECO:0000313|Proteomes:UP000288253};
RA Johnson R.C., Deming C., Conlan S., Zellmer C.J., Michelin A.V.,
RA Lee-Lin S., Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P.,
RA Frank K.M., Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F.,
RA Palmore T.N., Segre J.A.;
RT "Genomic and Epidemiologic Investigation of an Indolent Hospital
RT Outbreak.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the phosphoribosylformylglycinamidine synthase
CC complex involved in the purines biosynthetic pathway. Catalyzes the
CC ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and
CC glutamine to yield formylglycinamidine ribonucleotide (FGAM) and
CC glutamate. The FGAM synthase complex is composed of three subunits.
CC PurQ produces an ammonia molecule by converting glutamine to glutamate.
CC PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-
CC dependent manner. PurS interacts with PurQ and PurL and is thought to
CC assist in the transfer of the ammonia molecule from PurQ to PurL.
CC {ECO:0000256|HAMAP-Rule:MF_00421}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-
CC ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-
CC ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate;
CC Xref=Rhea:RHEA:17129, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:147286, ChEBI:CHEBI:147287,
CC ChEBI:CHEBI:456216; EC=6.3.5.3; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00421};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00421};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2. {ECO:0000256|HAMAP-
CC Rule:MF_00421}.
CC -!- SUBUNIT: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ
CC and 2 PurS subunits. {ECO:0000256|HAMAP-Rule:MF_00421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00421}.
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DR EMBL; CP018820; APR52287.1; -; Genomic_DNA.
DR EMBL; PGEN01000001; PJI88264.1; -; Genomic_DNA.
DR EMBL; QLJD01000005; RSU19819.1; -; Genomic_DNA.
DR EMBL; QLJF01000006; RSU26607.1; -; Genomic_DNA.
DR EMBL; QLJC01000007; RSU27388.1; -; Genomic_DNA.
DR EMBL; QLJI01000014; RSU32376.1; -; Genomic_DNA.
DR EMBL; QLJE01000006; RSU38680.1; -; Genomic_DNA.
DR EMBL; QLJJ01000005; RSU41916.1; -; Genomic_DNA.
DR EMBL; QLJG01000005; RSU50809.1; -; Genomic_DNA.
DR EMBL; QQWJ01000019; RSU57643.1; -; Genomic_DNA.
DR EMBL; QQWK01000019; RSU65758.1; -; Genomic_DNA.
DR EMBL; QQWL01000014; RSU76875.1; -; Genomic_DNA.
DR EMBL; QQWM01000006; RSU80421.1; -; Genomic_DNA.
DR EMBL; QQWQ01000013; RSU86642.1; -; Genomic_DNA.
DR EMBL; QQWN01000023; RSU91327.1; -; Genomic_DNA.
DR EMBL; QQWP01000005; RSU96335.1; -; Genomic_DNA.
DR EMBL; QQWO01000014; RSV00921.1; -; Genomic_DNA.
DR EMBL; QQWS01000006; RSV06032.1; -; Genomic_DNA.
DR EMBL; QQWR01000005; RSV09429.1; -; Genomic_DNA.
DR EMBL; QQWU01000006; RSV24106.1; -; Genomic_DNA.
DR EMBL; QQWT01000013; RSV25113.1; -; Genomic_DNA.
DR EMBL; QQXA01000013; RSV34755.1; -; Genomic_DNA.
DR EMBL; QQXB01000015; RSV42977.1; -; Genomic_DNA.
DR EMBL; QQXD01000025; RSV53095.1; -; Genomic_DNA.
DR EMBL; QQXE01000015; RSV54380.1; -; Genomic_DNA.
DR EMBL; QQXG01000010; RSV62467.1; -; Genomic_DNA.
DR EMBL; QQXC01000017; RSW92420.1; -; Genomic_DNA.
DR EMBL; QQXQ01000007; RSX05655.1; -; Genomic_DNA.
DR EMBL; QQXR01000006; RSX08022.1; -; Genomic_DNA.
DR EMBL; QQXF01000008; RSX12094.1; -; Genomic_DNA.
DR EMBL; QQXV01000001; RSX22838.1; -; Genomic_DNA.
DR EMBL; QQXS01000006; RSX23702.1; -; Genomic_DNA.
DR EMBL; QQXT01000006; RSX27275.1; -; Genomic_DNA.
DR EMBL; QQXU01000002; RSX33982.1; -; Genomic_DNA.
DR EMBL; QQXW01000006; RSX37683.1; -; Genomic_DNA.
DR EMBL; QQXX01000005; RSX42428.1; -; Genomic_DNA.
DR EMBL; QQXY01000003; RSX46905.1; -; Genomic_DNA.
DR EMBL; QQYA01000004; RSX63542.1; -; Genomic_DNA.
DR EMBL; QQYD01000004; RSX66522.1; -; Genomic_DNA.
DR EMBL; QQXZ01000004; RSX69212.1; -; Genomic_DNA.
DR EMBL; QQYC01000006; RSX73658.1; -; Genomic_DNA.
DR EMBL; QQYB01000005; RSX79636.1; -; Genomic_DNA.
DR EMBL; QQYH01000005; RSX83770.1; -; Genomic_DNA.
DR EMBL; QQYF01000016; RSX84025.1; -; Genomic_DNA.
DR EMBL; QQYG01000008; RSX90813.1; -; Genomic_DNA.
DR EMBL; QQYE01000001; RSX99798.1; -; Genomic_DNA.
DR EMBL; QQYJ01000006; RSY00948.1; -; Genomic_DNA.
DR EMBL; QQYI01000005; RSY07130.1; -; Genomic_DNA.
DR EMBL; QQYK01000006; RSY12565.1; -; Genomic_DNA.
DR EMBL; QQYN01000005; RSY12741.1; -; Genomic_DNA.
DR EMBL; QQYO01000014; RSY20183.1; -; Genomic_DNA.
DR EMBL; QQYL01000006; RSY20343.1; -; Genomic_DNA.
DR EMBL; QQYM01000006; RSY27765.1; -; Genomic_DNA.
DR EMBL; QQYS01000006; RSY33131.1; -; Genomic_DNA.
DR EMBL; QQYQ01000007; RSY37629.1; -; Genomic_DNA.
DR EMBL; QQYP01000006; RSY43705.1; -; Genomic_DNA.
DR EMBL; QQYR01000007; RSY44133.1; -; Genomic_DNA.
DR EMBL; QQYV01000006; RSY55953.1; -; Genomic_DNA.
DR EMBL; QQYU01000001; RSY56679.1; -; Genomic_DNA.
DR EMBL; QQYW01000004; RSY61706.1; -; Genomic_DNA.
DR EMBL; QQYT01000007; RSY63748.1; -; Genomic_DNA.
DR EMBL; QQYY01000006; RSY70778.1; -; Genomic_DNA.
DR EMBL; QQYX01000005; RSY71458.1; -; Genomic_DNA.
DR EMBL; QQYZ01000016; RSY80607.1; -; Genomic_DNA.
DR EMBL; QQZB01000007; RSY81846.1; -; Genomic_DNA.
DR EMBL; QQZA01000008; RSY84812.1; -; Genomic_DNA.
DR EMBL; QQZD01000007; RSY94568.1; -; Genomic_DNA.
DR EMBL; QQZE01000010; RSY98186.1; -; Genomic_DNA.
DR EMBL; QQZG01000004; RSZ01127.1; -; Genomic_DNA.
DR EMBL; QQZC01000005; RSZ09687.1; -; Genomic_DNA.
DR EMBL; QQZF01000006; RSZ10733.1; -; Genomic_DNA.
DR EMBL; QQZH01000003; RSZ16279.1; -; Genomic_DNA.
DR EMBL; QQZI01000016; RSZ18756.1; -; Genomic_DNA.
DR RefSeq; WP_066580389.1; NZ_QQZI01000016.1.
DR STRING; 93064.BRX40_07470; -.
DR GeneID; 44132391; -.
DR KEGG; skr:BRX40_07470; -.
DR OrthoDB; 9804441at2; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000185161; Chromosome.
DR Proteomes; UP000228629; Unassembled WGS sequence.
DR Proteomes; UP000286681; Unassembled WGS sequence.
DR Proteomes; UP000286696; Unassembled WGS sequence.
DR Proteomes; UP000286706; Unassembled WGS sequence.
DR Proteomes; UP000286710; Unassembled WGS sequence.
DR Proteomes; UP000286739; Unassembled WGS sequence.
DR Proteomes; UP000286744; Unassembled WGS sequence.
DR Proteomes; UP000286760; Unassembled WGS sequence.
DR Proteomes; UP000286788; Unassembled WGS sequence.
DR Proteomes; UP000286792; Unassembled WGS sequence.
DR Proteomes; UP000286795; Unassembled WGS sequence.
DR Proteomes; UP000286956; Unassembled WGS sequence.
DR Proteomes; UP000286970; Unassembled WGS sequence.
DR Proteomes; UP000287001; Unassembled WGS sequence.
DR Proteomes; UP000287015; Unassembled WGS sequence.
DR Proteomes; UP000287020; Unassembled WGS sequence.
DR Proteomes; UP000287028; Unassembled WGS sequence.
DR Proteomes; UP000287038; Unassembled WGS sequence.
DR Proteomes; UP000287073; Unassembled WGS sequence.
DR Proteomes; UP000287083; Unassembled WGS sequence.
DR Proteomes; UP000287090; Unassembled WGS sequence.
DR Proteomes; UP000287165; Unassembled WGS sequence.
DR Proteomes; UP000287229; Unassembled WGS sequence.
DR Proteomes; UP000287236; Unassembled WGS sequence.
DR Proteomes; UP000287257; Unassembled WGS sequence.
DR Proteomes; UP000287271; Unassembled WGS sequence.
DR Proteomes; UP000287307; Unassembled WGS sequence.
DR Proteomes; UP000287315; Unassembled WGS sequence.
DR Proteomes; UP000287340; Unassembled WGS sequence.
DR Proteomes; UP000287347; Unassembled WGS sequence.
DR Proteomes; UP000287360; Unassembled WGS sequence.
DR Proteomes; UP000287363; Unassembled WGS sequence.
DR Proteomes; UP000287377; Unassembled WGS sequence.
DR Proteomes; UP000287414; Unassembled WGS sequence.
DR Proteomes; UP000287417; Unassembled WGS sequence.
DR Proteomes; UP000287457; Unassembled WGS sequence.
DR Proteomes; UP000287482; Unassembled WGS sequence.
DR Proteomes; UP000287513; Unassembled WGS sequence.
DR Proteomes; UP000287541; Unassembled WGS sequence.
DR Proteomes; UP000287577; Unassembled WGS sequence.
DR Proteomes; UP000287746; Unassembled WGS sequence.
DR Proteomes; UP000287793; Unassembled WGS sequence.
DR Proteomes; UP000287799; Unassembled WGS sequence.
DR Proteomes; UP000287806; Unassembled WGS sequence.
DR Proteomes; UP000287812; Unassembled WGS sequence.
DR Proteomes; UP000287844; Unassembled WGS sequence.
DR Proteomes; UP000287886; Unassembled WGS sequence.
DR Proteomes; UP000287968; Unassembled WGS sequence.
DR Proteomes; UP000287976; Unassembled WGS sequence.
DR Proteomes; UP000288007; Unassembled WGS sequence.
DR Proteomes; UP000288050; Unassembled WGS sequence.
DR Proteomes; UP000288130; Unassembled WGS sequence.
DR Proteomes; UP000288181; Unassembled WGS sequence.
DR Proteomes; UP000288198; Unassembled WGS sequence.
DR Proteomes; UP000288203; Unassembled WGS sequence.
DR Proteomes; UP000288207; Unassembled WGS sequence.
DR Proteomes; UP000288230; Unassembled WGS sequence.
DR Proteomes; UP000288253; Unassembled WGS sequence.
DR Proteomes; UP000288258; Unassembled WGS sequence.
DR Proteomes; UP000288269; Unassembled WGS sequence.
DR Proteomes; UP000288283; Unassembled WGS sequence.
DR Proteomes; UP000288286; Unassembled WGS sequence.
DR Proteomes; UP000288342; Unassembled WGS sequence.
DR Proteomes; UP000288435; Unassembled WGS sequence.
DR Proteomes; UP000288516; Unassembled WGS sequence.
DR Proteomes; UP000288528; Unassembled WGS sequence.
DR Proteomes; UP000288535; Unassembled WGS sequence.
DR Proteomes; UP000288569; Unassembled WGS sequence.
DR Proteomes; UP000288581; Unassembled WGS sequence.
DR Proteomes; UP000288630; Unassembled WGS sequence.
DR Proteomes; UP000288648; Unassembled WGS sequence.
DR Proteomes; UP000288649; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR HAMAP; MF_00421; PurQ; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010075; PRibForGlyAmidine_synth_PurQ.
DR NCBIfam; TIGR01737; FGAM_synth_I; 1.
DR PANTHER; PTHR47552; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ; 1.
DR PANTHER; PTHR47552:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ; 1.
DR Pfam; PF13507; GATase_5; 1.
DR PIRSF; PIRSF001586; FGAM_synth_I; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00421};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00421};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|HAMAP-Rule:MF_00421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00421};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00421};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00421};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, ECO:0000256|HAMAP-
KW Rule:MF_00421}; Reference proteome {ECO:0000313|Proteomes:UP000185161}.
FT ACT_SITE 87
FT /note="Nucleophile"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00421,
FT ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 195
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00421,
FT ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 197
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00421,
FT ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 221 AA; 23336 MW; 29D70CC3E0ED8BD1 CRC64;
MKSAVIVFPG SNCDRDLAVA IESVTGTKPH MVWHGESELP DGLGLIALPG GFSYGDYLRC
GAIAARSPVV KAVVAAAERG TPVIGICNGF QVLTETGLLP GALMRNEGLN FVCRDVALTV
DNSQTIFTSR YAAGETLSVP VAHHDGNYFA DKETLDRLEG EGRVAFRYGE EVNGSARQIA
GIVNAAGNVL GMMPHPERKI EAAHGGIDGR RLFEGLLEAV S
//
