ID   A0A1L6JAH1_9SPHN        Unreviewed;       695 AA.
AC   A0A1L6JAH1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE   AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE   AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN   ORFNames=BDW16_1293 {ECO:0000313|EMBL:PJI88029.1}, BRX38_15750
GN   {ECO:0000313|EMBL:RSU38434.1}, BRX39_15740
GN   {ECO:0000313|EMBL:RSU32491.1}, BRX40_08700
GN   {ECO:0000313|EMBL:APR52500.1}, CA221_16535
GN   {ECO:0000313|EMBL:RSU48274.1}, CA222_18115
GN   {ECO:0000313|EMBL:RSU22223.1}, CA223_18230
GN   {ECO:0000313|EMBL:RSU35314.1}, CA224_18210
GN   {ECO:0000313|EMBL:RSU17988.1}, CA225_17900
GN   {ECO:0000313|EMBL:RSU23874.1}, CA226_19415
GN   {ECO:0000313|EMBL:RSV59412.1}, CA227_20230
GN   {ECO:0000313|EMBL:RSX06866.1}, CA228_15955
GN   {ECO:0000313|EMBL:RSV54803.1}, CA229_13350
GN   {ECO:0000313|EMBL:RSV54946.1}, CA230_17075
GN   {ECO:0000313|EMBL:RSW92547.1}, CA231_00335
GN   {ECO:0000313|EMBL:RSV49856.1}, CA231_02110
GN   {ECO:0000313|EMBL:RSV49902.1}, CA232_15820
GN   {ECO:0000313|EMBL:RSV34970.1}, CA238_18115
GN   {ECO:0000313|EMBL:RSV21481.1}, CA239_18225
GN   {ECO:0000313|EMBL:RSV24971.1}, CA240_17650
GN   {ECO:0000313|EMBL:RSV02834.1}, CA242_19055
GN   {ECO:0000313|EMBL:RSV04002.1}, CA253_17030
GN   {ECO:0000313|EMBL:RSU86514.1}, CA256_15810
GN   {ECO:0000313|EMBL:RSU92715.1}, CA257_15390
GN   {ECO:0000313|EMBL:RSV01195.1}, DAH52_16925
GN   {ECO:0000313|EMBL:RSU92607.1}, DAH53_18795
GN   {ECO:0000313|EMBL:RSU76011.1}, DAH54_17810
GN   {ECO:0000313|EMBL:RSU76436.1}, DAH55_17240
GN   {ECO:0000313|EMBL:RSU65556.1}, DAH56_17575
GN   {ECO:0000313|EMBL:RSU57376.1}, DAH57_18075
GN   {ECO:0000313|EMBL:RSZ18911.1}, DAH58_07585
GN   {ECO:0000313|EMBL:RSZ16487.1}, DAH59_18645
GN   {ECO:0000313|EMBL:RSY93743.1}, DAH60_17085
GN   {ECO:0000313|EMBL:RSZ07381.1}, DAH61_09700
GN   {ECO:0000313|EMBL:RSZ00946.1}, DAH62_19465
GN   {ECO:0000313|EMBL:RSY91295.1}, DAH63_16910
GN   {ECO:0000313|EMBL:RSZ06464.1}, DAH64_19040
GN   {ECO:0000313|EMBL:RSY78620.1}, DAH65_20405
GN   {ECO:0000313|EMBL:RSY80110.1}, DAH66_13070
GN   {ECO:0000313|EMBL:RSY83189.1}, DAH67_20270
GN   {ECO:0000313|EMBL:RSY67669.1}, DAH68_17015
GN   {ECO:0000313|EMBL:RSY67501.1}, DAH69_17105
GN   {ECO:0000313|EMBL:RSY59416.1}, DAH70_19245
GN   {ECO:0000313|EMBL:RSY49031.1}, DAH71_01220
GN   {ECO:0000313|EMBL:RSY56471.1}, DAH72_19210
GN   {ECO:0000313|EMBL:RSY57987.1}, DAH73_20360
GN   {ECO:0000313|EMBL:RSY30012.1}, DAH74_18765
GN   {ECO:0000313|EMBL:RSY42613.1}, DAH75_18725
GN   {ECO:0000313|EMBL:RSY34103.1}, DAH76_18585
GN   {ECO:0000313|EMBL:RSY37577.1}, DAH77_10465
GN   {ECO:0000313|EMBL:RSY24758.1}, DAH78_19105
GN   {ECO:0000313|EMBL:RSY08296.1}, DAH79_18605
GN   {ECO:0000313|EMBL:RSY23560.1}, DAH80_18425
GN   {ECO:0000313|EMBL:RSY17186.1}, DAH81_17485
GN   {ECO:0000313|EMBL:RSY09308.1}, DAH82_16955
GN   {ECO:0000313|EMBL:RSX98929.1}, DAH83_16010
GN   {ECO:0000313|EMBL:RSY03971.1}, DAH84_14995
GN   {ECO:0000313|EMBL:RSX80068.1}, DAH85_18395
GN   {ECO:0000313|EMBL:RSX87953.1}, DAH86_17825
GN   {ECO:0000313|EMBL:RSX84154.1}, DAH87_01795
GN   {ECO:0000313|EMBL:RSX99592.1}, DAH88_18595
GN   {ECO:0000313|EMBL:RSX59566.1}, DAH89_18475
GN   {ECO:0000313|EMBL:RSX70110.1}, DAH90_16950
GN   {ECO:0000313|EMBL:RSX75509.1}, DAH91_16595
GN   {ECO:0000313|EMBL:RSX59512.1}, DAH92_16245
GN   {ECO:0000313|EMBL:RSX65544.1}, DAH93_17690
GN   {ECO:0000313|EMBL:RSX39038.1}, DAH94_17175
GN   {ECO:0000313|EMBL:RSX40911.1}, DAH95_16250
GN   {ECO:0000313|EMBL:RSX36726.1}, DAH96_01560
GN   {ECO:0000313|EMBL:RSX23478.1}, DAH97_04935
GN   {ECO:0000313|EMBL:RSX34451.1}, DAH98_16590
GN   {ECO:0000313|EMBL:RSX24974.1}, DAH99_17760
GN   {ECO:0000313|EMBL:RSX19734.1}, DAI00_19095
GN   {ECO:0000313|EMBL:RSX04395.1}, DAI01_18865
GN   {ECO:0000313|EMBL:RSX03452.1};
OS   Sphingomonas koreensis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=93064 {ECO:0000313|EMBL:APR52500.1, ECO:0000313|Proteomes:UP000185161};
RN   [1] {ECO:0000313|EMBL:APR52500.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ABOJV {ECO:0000313|EMBL:APR52500.1};
RA   Conlan S., Thomas P.J., Mullikin J., Palmore T.N., Frank K.M., Segre J.A.;
RT   "Whole genome sequencing of Sphingomonas koreensis.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000185161}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABOJV {ECO:0000313|Proteomes:UP000185161};
RA   Conlan S., Thomas P.J., Mullikin J., Palmore T.N., Frank K.M., Segre J.A.;
RT   "Whole genome sequencing of Sphingomonas sp. ABOJV.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000228629}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSS26 {ECO:0000313|Proteomes:UP000228629};
RA   Blow M.;
RT   "Pac Bio to generate improved reference genome sequences for organisms with
RT   transposon mutant libraries (support for FEBA project).";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:PJI88029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSS26 {ECO:0000313|EMBL:PJI88029.1};
RA   Han C.G.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:PJI88029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSS26 {ECO:0000313|EMBL:PJI88029.1};
RX   PubMed=29769716; DOI=10.1038/s41586-018-0124-0;
RA   Price M.N., Wetmore K.M., Waters R.J., Callaghan M., Ray J., Liu H.,
RA   Kuehl J.V., Melnyk R.A., Lamson J.S., Suh Y., Carlson H.K., Esquivel Z.,
RA   Sadeeshkumar H., Chakraborty R., Zane G.M., Rubin B.E., Wall J.D.,
RA   Visel A., Bristow J., Blow M.J., Arkin A.P., Deutschbauer A.M.;
RT   "Mutant phenotypes for thousands of bacterial genes of unknown function.";
RL   Nature 557:503-509(2018).
RN   [6] {ECO:0000313|Proteomes:UP000286970, ECO:0000313|Proteomes:UP000287271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK-NIH.Env2_1116 {ECO:0000313|EMBL:RSU22223.1,
RC   ECO:0000313|Proteomes:UP000286970}, SK-NIH.Env3_1116
RC   {ECO:0000313|EMBL:RSU35314.1, ECO:0000313|Proteomes:UP000287271},
RC   SK-NIH.Env4_1116 {ECO:0000313|EMBL:RSU17988.1,
RC   ECO:0000313|Proteomes:UP000287347}, SK-NIH.Env8_1116
RC   {ECO:0000313|EMBL:RSU23874.1, ECO:0000313|Proteomes:UP000287976},
RC   SK-NIH.Pt2_0716 {ECO:0000313|EMBL:RSU38434.1,
RC   ECO:0000313|Proteomes:UP000287307}, SK-NIH.Pt4_0816
RC   {ECO:0000313|EMBL:RSU32491.1, ECO:0000313|Proteomes:UP000287414}, and
RC   SK-NIH.Pt6_1016 {ECO:0000313|EMBL:RSU48274.1,
RC   ECO:0000313|Proteomes:UP000287315};
RA   Johnson R.C., Deming C., Conlan S., Zellmer C., Michelin A., Lee-Lin S.-Q.,
RA   Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P., Frank K.M.,
RA   Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F., Palmore T.N.,
RA   Segre J.A.;
RT   "Genomic and Epidemiologic Investigation to Identify Sphingomonas koreensis
RT   Point Sources in an Indolent Hospital Outbreak.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000286706, ECO:0000313|Proteomes:UP000286739}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK-NIH.Env13_0417 {ECO:0000313|EMBL:RSZ16487.1,
RC   ECO:0000313|Proteomes:UP000287513}, SK-NIH.Env14_0417
RC   {ECO:0000313|EMBL:RSY93743.1, ECO:0000313|Proteomes:UP000288569},
RC   SK-NIH.Env16_0517 {ECO:0000313|EMBL:RSZ07381.1,
RC   ECO:0000313|Proteomes:UP000287015}, SK-NIH.Env17_0517
RC   {ECO:0000313|EMBL:RSZ18911.1, ECO:0000313|Proteomes:UP000287799},
RC   SK-NIH.Env18_0517 {ECO:0000313|EMBL:RSZ00946.1,
RC   ECO:0000313|Proteomes:UP000288230}, SK-NIH.Env19_0617
RC   {ECO:0000313|EMBL:RSY78620.1, ECO:0000313|Proteomes:UP000288258},
RC   SK-NIH.Env20_0617 {ECO:0000313|EMBL:RSY80110.1,
RC   ECO:0000313|Proteomes:UP000287482}, SK-NIH.Env21_0617
RC   {ECO:0000313|EMBL:RSY91295.1, ECO:0000313|Proteomes:UP000287363},
RC   SK-NIH.Env22_0617 {ECO:0000313|EMBL:RSZ06464.1,
RC   ECO:0000313|Proteomes:UP000287001}, SK-NIH.Env23_0717
RC   {ECO:0000313|EMBL:RSY67669.1, ECO:0000313|Proteomes:UP000287360},
RC   SK-NIH.Env24_0717 {ECO:0000313|EMBL:RSY67501.1,
RC   ECO:0000313|Proteomes:UP000287229}, SK-NIH.Env25_0717
RC   {ECO:0000313|EMBL:RSY59416.1, ECO:0000313|Proteomes:UP000288269},
RC   SK-NIH.Env26_0717 {ECO:0000313|EMBL:RSY49031.1,
RC   ECO:0000313|Proteomes:UP000287417}, SK-NIH.Env27_0717
RC   {ECO:0000313|EMBL:RSY56471.1, ECO:0000313|Proteomes:UP000286788},
RC   SK-NIH.Env28_0717 {ECO:0000313|EMBL:RSY57987.1,
RC   ECO:0000313|Proteomes:UP000288630}, SK-NIH.Env29_0717
RC   {ECO:0000313|EMBL:RSY30012.1, ECO:0000313|Proteomes:UP000287038},
RC   SK-NIH.Env30_0717 {ECO:0000313|EMBL:RSY42613.1,
RC   ECO:0000313|Proteomes:UP000288207}, SK-NIH.Env31_0717
RC   {ECO:0000313|EMBL:RSY34103.1, ECO:0000313|Proteomes:UP000287340},
RC   SK-NIH.Env32_0717 {ECO:0000313|EMBL:RSY37577.1,
RC   ECO:0000313|Proteomes:UP000288007}, SK-NIH.Env33_0717
RC   {ECO:0000313|EMBL:RSY24758.1, ECO:0000313|Proteomes:UP000287541},
RC   SK-NIH.Env34_0717 {ECO:0000313|EMBL:RSY08296.1,
RC   ECO:0000313|Proteomes:UP000288649}, SK-NIH.Env35_0717
RC   {ECO:0000313|EMBL:RSY23560.1, ECO:0000313|Proteomes:UP000287968},
RC   SK-NIH.Env36_0717 {ECO:0000313|EMBL:RSX98929.1,
RC   ECO:0000313|Proteomes:UP000288516}, SK-NIH.Env37_0717
RC   {ECO:0000313|EMBL:RSY17186.1, ECO:0000313|Proteomes:UP000287028},
RC   SK-NIH.Env38_0817 {ECO:0000313|EMBL:RSY09308.1,
RC   ECO:0000313|Proteomes:UP000287257}, SK-NIH.Env39_0817
RC   {ECO:0000313|EMBL:RSY03971.1, ECO:0000313|Proteomes:UP000287073},
RC   SK-NIH.Env40_0817 {ECO:0000313|EMBL:RSX80068.1,
RC   ECO:0000313|Proteomes:UP000288050}, SK-NIH.Env41_0817
RC   {ECO:0000313|EMBL:RSX87953.1, ECO:0000313|Proteomes:UP000286739},
RC   SK-NIH.Env42_0817 {ECO:0000313|EMBL:RSX84154.1,
RC   ECO:0000313|Proteomes:UP000288181}, SK-NIH.Env43_0817
RC   {ECO:0000313|EMBL:RSX99592.1, ECO:0000313|Proteomes:UP000286795},
RC   SK-NIH.Env44_0817 {ECO:0000313|EMBL:RSX59566.1,
RC   ECO:0000313|Proteomes:UP000286792}, SK-NIH.Env45_1017
RC   {ECO:0000313|EMBL:RSX70110.1, ECO:0000313|Proteomes:UP000286760},
RC   SK-NIH.Env46_1017 {ECO:0000313|EMBL:RSX65544.1,
RC   ECO:0000313|Proteomes:UP000287577}, SK-NIH.Env47_1017
RC   {ECO:0000313|EMBL:RSX39038.1, ECO:0000313|Proteomes:UP000288581},
RC   SK-NIH.Env48_1017 {ECO:0000313|EMBL:RSX75509.1,
RC   ECO:0000313|Proteomes:UP000287090}, SK-NIH.Env49_1017
RC   {ECO:0000313|EMBL:RSX59512.1, ECO:0000313|Proteomes:UP000286744},
RC   SK-NIH.Env50_1017 {ECO:0000313|EMBL:RSX40911.1,
RC   ECO:0000313|Proteomes:UP000288198}, SK-NIH.Env51_1017
RC   {ECO:0000313|EMBL:RSX36726.1, ECO:0000313|Proteomes:UP000287844},
RC   SK-NIH.Env52_1017 {ECO:0000313|EMBL:RSX23478.1,
RC   ECO:0000313|Proteomes:UP000287083}, SK-NIH.Env53_1017
RC   {ECO:0000313|EMBL:RSX34451.1, ECO:0000313|Proteomes:UP000288435},
RC   SK-NIH.Env54_1217 {ECO:0000313|EMBL:RSX19734.1,
RC   ECO:0000313|Proteomes:UP000288203}, SK-NIH.Env55_1217
RC   {ECO:0000313|EMBL:RSX04395.1, ECO:0000313|Proteomes:UP000286706},
RC   SK-NIH.Env56_1217 {ECO:0000313|EMBL:RSX03452.1,
RC   ECO:0000313|Proteomes:UP000287020}, and SK-NIH.Env57_1217
RC   {ECO:0000313|EMBL:RSX24974.1, ECO:0000313|Proteomes:UP000287236};
RA   Johnson R.C., Deming C., Conlan S., Zellmer C.J., Michelin A.V.,
RA   Lee-Lin S.-Q., Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P.,
RA   Frank K.M., Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F.,
RA   Palmore T.N., Segre J.A.;
RT   "Genomic and Epidemiologic Investigation of an Indolent Hospital
RT   Outbreak.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Proteomes:UP000286681, ECO:0000313|Proteomes:UP000286696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 2882 {ECO:0000313|EMBL:RSU65556.1,
RC   ECO:0000313|Proteomes:UP000286710}, KCTC 2883
RC   {ECO:0000313|EMBL:RSU57376.1, ECO:0000313|Proteomes:UP000286956},
RC   SK-CDC1_0717 {ECO:0000313|EMBL:RSY83189.1,
RC   ECO:0000313|Proteomes:UP000287746}, SK-NIH.Env10_0317
RC   {ECO:0000313|EMBL:RSV01195.1, ECO:0000313|Proteomes:UP000286681},
RC   SK-NIH.Env11_0417 {ECO:0000313|EMBL:RSU76436.1,
RC   ECO:0000313|Proteomes:UP000287165}, SK-NIH.Env12_0417
RC   {ECO:0000313|EMBL:RSU92607.1, ECO:0000313|Proteomes:UP000288342},
RC   SK-NIH.Env15_0417 {ECO:0000313|EMBL:RSU76011.1,
RC   ECO:0000313|Proteomes:UP000288648}, SK-NIH.Env1_1016
RC   {ECO:0000313|EMBL:RSV59412.1, ECO:0000313|Proteomes:UP000288283},
RC   SK-NIH.Env5_1116 {ECO:0000313|EMBL:RSV54803.1,
RC   ECO:0000313|Proteomes:UP000287812}, SK-NIH.Env7_1116
RC   {ECO:0000313|EMBL:RSX06866.1, ECO:0000313|Proteomes:UP000288130},
RC   SK-NIH.Env9_0217 {ECO:0000313|EMBL:RSU86514.1,
RC   ECO:0000313|Proteomes:UP000287377}, SK-NIH.Pt10_0210
RC   {ECO:0000313|EMBL:RSV04002.1, ECO:0000313|Proteomes:UP000288286},
RC   SK-NIH.Pt11_0411 {ECO:0000313|EMBL:RSW92547.1,
RC   ECO:0000313|Proteomes:UP000288535}, SK-NIH.Pt12_0112
RC   {ECO:0000313|EMBL:RSV54946.1, ECO:0000313|Proteomes:UP000286696},
RC   SK-NIH.Pt14_0612 {ECO:0000313|EMBL:RSV34970.1,
RC   ECO:0000313|Proteomes:UP000287457}, SK-NIH.Pt16_1112
RC   {ECO:0000313|EMBL:RSV49856.1, ECO:0000313|Proteomes:UP000287806},
RC   SK-NIH.Pt7_0906 {ECO:0000313|EMBL:RSV21481.1,
RC   ECO:0000313|Proteomes:UP000288528}, SK-NIH.Pt8_0208
RC   {ECO:0000313|EMBL:RSV24971.1, ECO:0000313|Proteomes:UP000287886},
RC   SK-NIH.Pt9_0208 {ECO:0000313|EMBL:RSV02834.1,
RC   ECO:0000313|Proteomes:UP000287793}, and SK-NY1_0417
RC   {ECO:0000313|EMBL:RSU92715.1, ECO:0000313|Proteomes:UP000288253};
RA   Johnson R.C., Deming C., Conlan S., Zellmer C.J., Michelin A.V.,
RA   Lee-Lin S., Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P.,
RA   Frank K.M., Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F.,
RA   Palmore T.N., Segre J.A.;
RT   "Genomic and Epidemiologic Investigation of an Indolent Hospital
RT   Outbreak.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
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DR   EMBL; CP018820; APR52500.1; -; Genomic_DNA.
DR   EMBL; PGEN01000001; PJI88029.1; -; Genomic_DNA.
DR   EMBL; QLJD01000012; RSU17988.1; -; Genomic_DNA.
DR   EMBL; QLJF01000015; RSU22223.1; -; Genomic_DNA.
DR   EMBL; QLJC01000015; RSU23874.1; -; Genomic_DNA.
DR   EMBL; QLJI01000013; RSU32491.1; -; Genomic_DNA.
DR   EMBL; QLJE01000012; RSU35314.1; -; Genomic_DNA.
DR   EMBL; QLJJ01000013; RSU38434.1; -; Genomic_DNA.
DR   EMBL; QLJG01000012; RSU48274.1; -; Genomic_DNA.
DR   EMBL; QQWJ01000020; RSU57376.1; -; Genomic_DNA.
DR   EMBL; QQWK01000020; RSU65556.1; -; Genomic_DNA.
DR   EMBL; QQWM01000015; RSU76011.1; -; Genomic_DNA.
DR   EMBL; QQWL01000015; RSU76436.1; -; Genomic_DNA.
DR   EMBL; QQWQ01000014; RSU86514.1; -; Genomic_DNA.
DR   EMBL; QQWN01000018; RSU92607.1; -; Genomic_DNA.
DR   EMBL; QQWP01000013; RSU92715.1; -; Genomic_DNA.
DR   EMBL; QQWO01000013; RSV01195.1; -; Genomic_DNA.
DR   EMBL; QQWS01000012; RSV02834.1; -; Genomic_DNA.
DR   EMBL; QQWR01000018; RSV04002.1; -; Genomic_DNA.
DR   EMBL; QQWU01000014; RSV21481.1; -; Genomic_DNA.
DR   EMBL; QQWT01000014; RSV24971.1; -; Genomic_DNA.
DR   EMBL; QQXA01000012; RSV34970.1; -; Genomic_DNA.
DR   EMBL; QQXB01000001; RSV49856.1; -; Genomic_DNA.
DR   EMBL; QQXB01000001; RSV49902.1; -; Genomic_DNA.
DR   EMBL; QQXE01000013; RSV54803.1; -; Genomic_DNA.
DR   EMBL; QQXD01000015; RSV54946.1; -; Genomic_DNA.
DR   EMBL; QQXG01000016; RSV59412.1; -; Genomic_DNA.
DR   EMBL; QQXC01000016; RSW92547.1; -; Genomic_DNA.
DR   EMBL; QQXQ01000014; RSX03452.1; -; Genomic_DNA.
DR   EMBL; QQXR01000013; RSX04395.1; -; Genomic_DNA.
DR   EMBL; QQXF01000031; RSX06866.1; -; Genomic_DNA.
DR   EMBL; QQXS01000014; RSX19734.1; -; Genomic_DNA.
DR   EMBL; QQXV01000001; RSX23478.1; -; Genomic_DNA.
DR   EMBL; QQXT01000013; RSX24974.1; -; Genomic_DNA.
DR   EMBL; QQXU01000002; RSX34451.1; -; Genomic_DNA.
DR   EMBL; QQXW01000012; RSX36726.1; -; Genomic_DNA.
DR   EMBL; QQXY01000015; RSX39038.1; -; Genomic_DNA.
DR   EMBL; QQXX01000014; RSX40911.1; -; Genomic_DNA.
DR   EMBL; QQYA01000016; RSX59512.1; -; Genomic_DNA.
DR   EMBL; QQYD01000017; RSX59566.1; -; Genomic_DNA.
DR   EMBL; QQXZ01000012; RSX65544.1; -; Genomic_DNA.
DR   EMBL; QQYC01000015; RSX70110.1; -; Genomic_DNA.
DR   EMBL; QQYB01000015; RSX75509.1; -; Genomic_DNA.
DR   EMBL; QQYH01000014; RSX80068.1; -; Genomic_DNA.
DR   EMBL; QQYF01000015; RSX84154.1; -; Genomic_DNA.
DR   EMBL; QQYG01000015; RSX87953.1; -; Genomic_DNA.
DR   EMBL; QQYJ01000013; RSX98929.1; -; Genomic_DNA.
DR   EMBL; QQYE01000001; RSX99592.1; -; Genomic_DNA.
DR   EMBL; QQYI01000015; RSY03971.1; -; Genomic_DNA.
DR   EMBL; QQYN01000016; RSY08296.1; -; Genomic_DNA.
DR   EMBL; QQYK01000012; RSY09308.1; -; Genomic_DNA.
DR   EMBL; QQYL01000014; RSY17186.1; -; Genomic_DNA.
DR   EMBL; QQYM01000015; RSY23560.1; -; Genomic_DNA.
DR   EMBL; QQYO01000005; RSY24758.1; -; Genomic_DNA.
DR   EMBL; QQYS01000013; RSY30012.1; -; Genomic_DNA.
DR   EMBL; QQYQ01000014; RSY34103.1; -; Genomic_DNA.
DR   EMBL; QQYP01000014; RSY37577.1; -; Genomic_DNA.
DR   EMBL; QQYR01000012; RSY42613.1; -; Genomic_DNA.
DR   EMBL; QQYV01000015; RSY49031.1; -; Genomic_DNA.
DR   EMBL; QQYU01000001; RSY56471.1; -; Genomic_DNA.
DR   EMBL; QQYT01000013; RSY57987.1; -; Genomic_DNA.
DR   EMBL; QQYW01000012; RSY59416.1; -; Genomic_DNA.
DR   EMBL; QQYX01000014; RSY67501.1; -; Genomic_DNA.
DR   EMBL; QQYY01000015; RSY67669.1; -; Genomic_DNA.
DR   EMBL; QQZB01000016; RSY78620.1; -; Genomic_DNA.
DR   EMBL; QQZA01000017; RSY80110.1; -; Genomic_DNA.
DR   EMBL; QQYZ01000011; RSY83189.1; -; Genomic_DNA.
DR   EMBL; QQZD01000015; RSY91295.1; -; Genomic_DNA.
DR   EMBL; QQZG01000018; RSY93743.1; -; Genomic_DNA.
DR   EMBL; QQZE01000006; RSZ00946.1; -; Genomic_DNA.
DR   EMBL; QQZC01000012; RSZ06464.1; -; Genomic_DNA.
DR   EMBL; QQZF01000012; RSZ07381.1; -; Genomic_DNA.
DR   EMBL; QQZH01000003; RSZ16487.1; -; Genomic_DNA.
DR   EMBL; QQZI01000015; RSZ18911.1; -; Genomic_DNA.
DR   RefSeq; WP_066580889.1; NZ_QQZI01000015.1.
DR   STRING; 93064.BRX40_08700; -.
DR   GeneID; 44132635; -.
DR   KEGG; skr:BRX40_08700; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000185161; Chromosome.
DR   Proteomes; UP000228629; Unassembled WGS sequence.
DR   Proteomes; UP000286681; Unassembled WGS sequence.
DR   Proteomes; UP000286696; Unassembled WGS sequence.
DR   Proteomes; UP000286706; Unassembled WGS sequence.
DR   Proteomes; UP000286710; Unassembled WGS sequence.
DR   Proteomes; UP000286739; Unassembled WGS sequence.
DR   Proteomes; UP000286744; Unassembled WGS sequence.
DR   Proteomes; UP000286760; Unassembled WGS sequence.
DR   Proteomes; UP000286788; Unassembled WGS sequence.
DR   Proteomes; UP000286792; Unassembled WGS sequence.
DR   Proteomes; UP000286795; Unassembled WGS sequence.
DR   Proteomes; UP000286956; Unassembled WGS sequence.
DR   Proteomes; UP000286970; Unassembled WGS sequence.
DR   Proteomes; UP000287001; Unassembled WGS sequence.
DR   Proteomes; UP000287015; Unassembled WGS sequence.
DR   Proteomes; UP000287020; Unassembled WGS sequence.
DR   Proteomes; UP000287028; Unassembled WGS sequence.
DR   Proteomes; UP000287038; Unassembled WGS sequence.
DR   Proteomes; UP000287073; Unassembled WGS sequence.
DR   Proteomes; UP000287083; Unassembled WGS sequence.
DR   Proteomes; UP000287090; Unassembled WGS sequence.
DR   Proteomes; UP000287165; Unassembled WGS sequence.
DR   Proteomes; UP000287229; Unassembled WGS sequence.
DR   Proteomes; UP000287236; Unassembled WGS sequence.
DR   Proteomes; UP000287257; Unassembled WGS sequence.
DR   Proteomes; UP000287271; Unassembled WGS sequence.
DR   Proteomes; UP000287307; Unassembled WGS sequence.
DR   Proteomes; UP000287315; Unassembled WGS sequence.
DR   Proteomes; UP000287340; Unassembled WGS sequence.
DR   Proteomes; UP000287347; Unassembled WGS sequence.
DR   Proteomes; UP000287360; Unassembled WGS sequence.
DR   Proteomes; UP000287363; Unassembled WGS sequence.
DR   Proteomes; UP000287377; Unassembled WGS sequence.
DR   Proteomes; UP000287414; Unassembled WGS sequence.
DR   Proteomes; UP000287417; Unassembled WGS sequence.
DR   Proteomes; UP000287457; Unassembled WGS sequence.
DR   Proteomes; UP000287482; Unassembled WGS sequence.
DR   Proteomes; UP000287513; Unassembled WGS sequence.
DR   Proteomes; UP000287541; Unassembled WGS sequence.
DR   Proteomes; UP000287577; Unassembled WGS sequence.
DR   Proteomes; UP000287746; Unassembled WGS sequence.
DR   Proteomes; UP000287793; Unassembled WGS sequence.
DR   Proteomes; UP000287799; Unassembled WGS sequence.
DR   Proteomes; UP000287806; Unassembled WGS sequence.
DR   Proteomes; UP000287812; Unassembled WGS sequence.
DR   Proteomes; UP000287844; Unassembled WGS sequence.
DR   Proteomes; UP000287886; Unassembled WGS sequence.
DR   Proteomes; UP000287968; Unassembled WGS sequence.
DR   Proteomes; UP000287976; Unassembled WGS sequence.
DR   Proteomes; UP000288007; Unassembled WGS sequence.
DR   Proteomes; UP000288050; Unassembled WGS sequence.
DR   Proteomes; UP000288130; Unassembled WGS sequence.
DR   Proteomes; UP000288181; Unassembled WGS sequence.
DR   Proteomes; UP000288198; Unassembled WGS sequence.
DR   Proteomes; UP000288203; Unassembled WGS sequence.
DR   Proteomes; UP000288207; Unassembled WGS sequence.
DR   Proteomes; UP000288230; Unassembled WGS sequence.
DR   Proteomes; UP000288253; Unassembled WGS sequence.
DR   Proteomes; UP000288258; Unassembled WGS sequence.
DR   Proteomes; UP000288269; Unassembled WGS sequence.
DR   Proteomes; UP000288283; Unassembled WGS sequence.
DR   Proteomes; UP000288286; Unassembled WGS sequence.
DR   Proteomes; UP000288342; Unassembled WGS sequence.
DR   Proteomes; UP000288435; Unassembled WGS sequence.
DR   Proteomes; UP000288516; Unassembled WGS sequence.
DR   Proteomes; UP000288528; Unassembled WGS sequence.
DR   Proteomes; UP000288535; Unassembled WGS sequence.
DR   Proteomes; UP000288569; Unassembled WGS sequence.
DR   Proteomes; UP000288581; Unassembled WGS sequence.
DR   Proteomes; UP000288630; Unassembled WGS sequence.
DR   Proteomes; UP000288648; Unassembled WGS sequence.
DR   Proteomes; UP000288649; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 2.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:APR52500.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185161}.
FT   DOMAIN          45..144
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          383..444
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          623..695
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   695 AA;  77854 MW;  79CE1D89651D29BD CRC64;
     MLRQYELVDR VLSYDPEADE ALLNRAYVFS MHAHGSQKRA SGDPYFSHPI EVAGILTDLH
     LDDETIATAI LHDTIEDTVA TPEEILSKFG PSVARLVDGV TKLSKIEAQT ENERAAENLR
     KFLLAMSDDI RVLLVKLADR LHNMRTLHHI PKPEKRRRIA RETMDIYAPL AERIGMYEFM
     TEMQTLAFRE LEPEAYESIT KRLEGLKIEG EDRIAKIGSG FKLLLSRGGV DAEVLGREKH
     PYSIWKKMSE RHVSFEQLSD IMAFRAIVGT EEECYRALGI IHRRWPFVPG RFKDYISTPK
     RNGYRSLHTT VMHAGDTRVE IQIRTQEMHA QAEHGLAAHW AYKQSGVRPD TQVRWIQDLV
     EILETAESPE ELLEHTRMAM YQDRIFAFTP KGELIQLPKG ATPIDFAYAV HTDLGDQAVG
     AKINGQVVPL RTEIQQGDQV AILRSKAQRP QDNWLNFAIT GKARAAIRRH LRHKELDETI
     ALGRKLYDDI VRRLPVPIGE EALGAALTRL KLDDADALME AIARRKLSDV QVMEALMPGS
     TEGDLAPLPA TRDPISIKGL TPGVAFTLAP CCHPIPGDRI VGVRQPGEPI EIHQISCPKL
     DNVEDKDWID IGWGDKAEGG TARIAVTVKN EPGALGAVAT LLGQHKANIL NIRFDTRDTT
     FHTNMIDLEV RDAAHLMKLI GALRAADAVS SAERA
//