ID A0A1L7CG42_9CORY Unreviewed; 724 AA.
AC A0A1L7CG42;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=CAQU_06770 {ECO:0000313|EMBL:APT84817.1};
OS Corynebacterium aquilae DSM 44791.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1431546 {ECO:0000313|EMBL:APT84817.1, ECO:0000313|Proteomes:UP000185478};
RN [1] {ECO:0000313|EMBL:APT84817.1, ECO:0000313|Proteomes:UP000185478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S-613 {ECO:0000313|EMBL:APT84817.1,
RC ECO:0000313|Proteomes:UP000185478};
RA Ruckert C., Albersmeier A., Winkler A., Kalinowski J.;
RT "Complete genome sequence of Corynebacterium aquilae S-613T(T) (=DSM
RT 44791(T)), isolated from the choana of a healthy golden eagle.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP009245; APT84817.1; -; Genomic_DNA.
DR RefSeq; WP_075728489.1; NZ_CP009245.1.
DR AlphaFoldDB; A0A1L7CG42; -.
DR STRING; 1431546.CAQU_06770; -.
DR KEGG; caqu:CAQU_06770; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000185478; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000185478};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..600
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 354..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 80044 MW; 28CDC43EF050F53F CRC64;
MADPTTYRPA PGTIPSEPGV YKFRDDSGRV IYVGKAKNLA ARLSNYFQDL SQLHPRTRTM
VTTACSVEWT VVASEVEALQ LEYTWIKRFD PRFNVKYRDD KTYPLLAVST GEKVPRAFVY
RGPRRKGVRY FGPYSHAWAI RETLDLLLRV FPVRTCAPGV YRRHERLERP CLLGYIDKCA
APCVGRVSAA EYAEIVGGFV SFMAGNTDRV VRSLEKEMHA AAEELDFEKA ARLRDDVGAV
KRAMEQQAVV LGDGTDADVI AVAVDELEAS VQIFHVRAGR IRGQRGWVVE KPDVTAIPGG
SQPAPSGDSQ EQELPAAVRG VGDISGADPA VAQLLQDFLA QFYGDSVTRA REERELDQKL
ELQASGASTD TGDGPVARRG VDQQSHEAVE ESPIPREVLV QVLPADVEMM TGYLSDLRGS
QVSVRVPQRG DKKALMDTVA RNALEALKQH KLKRVGDLTA RSAALHEIQE ALGMDQAPLR
IECTDISHIQ GTDVVASLVV FEDGLPKKSD YRRYKISQAA GDGRSDDVGS IREVTRRRFL
RHRKGATEVP EESEFDGSRF ADEKVQVEEQ SVTGKAFAYP PQLFIVDGGL PQVNAAAEVF
DELGVGDVML IGLAKRLEEV WLPGEEDPVI LPRNSQGLFL LQHIRDEAHR FAITFHRQQR
SKRMRSSQLD GIKGLGAVRR TELVKHFGSV AQLKKASVED IAQVKGFGPR LAEEVFRALH
PSSG
//
