ID A0A1L7D2B1_9CORY Unreviewed; 169 AA.
AC A0A1L7D2B1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=3'-5' exoribonuclease {ECO:0000256|HAMAP-Rule:MF_00977};
DE EC=3.1.13.- {ECO:0000256|HAMAP-Rule:MF_00977};
GN ORFNames=CPHO_04150 {ECO:0000313|EMBL:APT92213.1};
OS Corynebacterium phocae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=161895 {ECO:0000313|EMBL:APT92213.1, ECO:0000313|Proteomes:UP000185491};
RN [1] {ECO:0000313|EMBL:APT92213.1, ECO:0000313|Proteomes:UP000185491}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M408/89/1 {ECO:0000313|EMBL:APT92213.1,
RC ECO:0000313|Proteomes:UP000185491};
RA Ruckert C., Albersmeier A., Winkler A., Kalinowski J.;
RT "Complete genome sequence of Corynebacterium phocae M408/89/1(T)(=DSM
RT 44612(T)), isolated from the common seal (Phoca vitulina).";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Exonuclease that cleaves single-stranded 3' overhangs of
CC double-stranded RNA. {ECO:0000256|HAMAP-Rule:MF_00977}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00977};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00977};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00977}.
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DR EMBL; CP009249; APT92213.1; -; Genomic_DNA.
DR RefSeq; WP_075733464.1; NZ_VXKJ01000034.1.
DR AlphaFoldDB; A0A1L7D2B1; -.
DR STRING; 161895.CPHO_04150; -.
DR KEGG; cpho:CPHO_04150; -.
DR OrthoDB; 4640719at2; -.
DR Proteomes; UP000185491; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004532; F:RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR HAMAP; MF_00977; 3_5_Exoribonuc_actinobact; 1.
DR InterPro; IPR030853; 3_5_Exoribonuc_actinobac.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR033390; Rv2179c-like.
DR NCBIfam; NF033638; RNase_AS; 1.
DR Pfam; PF16473; Rv2179c-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_00977};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00977};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00977};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00977};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_00977};
KW Reference proteome {ECO:0000313|Proteomes:UP000185491}.
FT DOMAIN 2..155
FT /note="3'-5' exoribonuclease Rv2179c-like"
FT /evidence="ECO:0000259|Pfam:PF16473"
FT REGION 6..9
FT /note="RNA binding"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00977"
FT BINDING 6
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00977"
SQ SEQUENCE 169 AA; 19185 MW; 1BAC6145637C8153 CRC64;
MRYFYDTEFI EDGQTIELVS IGIVAEDGRE YYAVSTDFDA AKANAWVREN VLNQLPSPSS
KAWKPLDTIR AEVLEFLCRP TSQVQLWAWV GAYDHVVLAQ LWGDMTGLPR TLPRYTRELR
QYWEFAGRPA LPPVPDGNHD ALVDARHNLA KFRACQAVLP LSASNKAIF
//
