ID A0A1L7F1U7_9PSEU Unreviewed; 1228 AA.
AC A0A1L7F1U7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=UA75_03775 {ECO:0000313|EMBL:APU18787.1};
OS Actinoalloteichus sp. GBA129-24.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinoalloteichus.
OX NCBI_TaxID=1612551 {ECO:0000313|EMBL:APU18787.1, ECO:0000313|Proteomes:UP000185506};
RN [1] {ECO:0000313|EMBL:APU18787.1, ECO:0000313|Proteomes:UP000185506}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GBA129-24 {ECO:0000313|EMBL:APU18787.1,
RC ECO:0000313|Proteomes:UP000185506};
RA Ruckert C., Nouioui I., Willmese J., van Wezel G., Klenk H.-P.,
RA Kalinowski J., Zotchev S.B.;
RT "Complete genome sequence of Actinoalloteichus fjordicus DSM 46856
RT (=GBA129-24).";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP016077; APU18787.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L7F1U7; -.
DR STRING; 1612551.UA75_03775; -.
DR KEGG; acti:UA75_03775; -.
DR Proteomes; UP000185506; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 661..822
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 840..997
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1228 AA; 132702 MW; BF653A76370D5A82 CRC64;
MSAPLAGLLT ALLGSKPFQN LVDAAGSATV ELGGPPALRT LVASALAAEQ GADRPVLLVT
ATGREAEESA AVLGDLIGRD VVAELPSWET LPHERLSPRA DTVGRRLAVL RRLAHPEQDS
PDTGPLRVVV TTVRSLIQPL APGLGEVAPV HLRVGEEHDF ASQVERLANL AYSRVDMVEK
RGEFAVRGGI LDVFPPTCEH PLRVEFWGDE VSEIRAFAVA DQRSLPEPVA ELLAPPCREL
LITASVRARA EALAADHRSD AQLSEMLDKI AAGIPVEGME ALIPALCEGE LALLPDLLPR
SAHVLLADPE KIRGRAADLV RTGQEFLEAS WMAAAGGGGA PIDLGASAYR DLDEIEQHTT
ASGRPWWTLS QLHLDAEDGD AGAEIDLVGG VRALQLDIRP VEAYRGEVER AFADLRAHTA
AGGAAVLVFP GAGTASRAAE QLRDADIPVR LITDGLPEAP ATGLVTIVRG TMEDGFIAAD
PLLVVLTEAD LTGGRGGTST RDMRRMPSRR RNAVDPLGLS AGDYVVHDKH GIGRYVEMSQ
RTVAGATREY LVLEYASSKR GQPGDRLFVP TDQLDEVSRY VGGELPTLNR LGGSDWAKTK
TRARKAVKEI AAELVQLYAA RQSAPGHAFG PDTPWQRELE DAFPYTETID QLAAIDEVKG
DMRRPVPMDR VICGDVGYGK TEIAVRAAFK AVQDGKQVVV LVPTTLLAQQ HLNTFSERMR
SFPVVVKGMS RFTDKMESDE VINGLAAGDV DVVIGTHRLL QTGIRYKDLG LVIVDEEQRF
GVEHKEHIKA LRTHVDVLTM SATPIPRTLE MSLAGIREMS TILTPPEERH PVLTYVGQYD
EKQTGAAIRR ELLRDGQVFY VHNRVSSIEK AAKRLRELVP EAKIVIAHGQ MNEDRLEKVI
QGFWEREFDV LVCTTIVETG LDISNANTLI VERGDMLGLA QLHQLRGRVG RARERGYAYF
LYPPEKPLTE TAHDRLATIA QNSELGSGMA VAMKDLEIRG AGNILGAEQS GHIAGVGFDL
YVRLVGEAVA AFRKQAGSDA GGDAVEEPAE VRIDLPVTAH IPHDYVAGER LRLEAYRKIA
SAAGDSPLDS RERVSADAEA LTAVRAELVD RYGPPPVEVD RLLAVSAFRQ LCRRYGVTEV
TLQGNAVRFA PMELRDSQIV RLERLYPKAT YKPALRLVSL PRPTEGGAGG RIGAPPLRDE
ALLSWAEGFL SAMAGVPAPA AASAGNRS
//
