ID   A0A1L7FFM9_9PSEU        Unreviewed;       829 AA.
AC   A0A1L7FFM9;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE            EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN   ORFNames=UA75_28295 {ECO:0000313|EMBL:APU23630.1};
OS   Actinoalloteichus sp. GBA129-24.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Actinoalloteichus.
OX   NCBI_TaxID=1612551 {ECO:0000313|EMBL:APU23630.1, ECO:0000313|Proteomes:UP000185506};
RN   [1] {ECO:0000313|EMBL:APU23630.1, ECO:0000313|Proteomes:UP000185506}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GBA129-24 {ECO:0000313|EMBL:APU23630.1,
RC   ECO:0000313|Proteomes:UP000185506};
RA   Ruckert C., Nouioui I., Willmese J., van Wezel G., Klenk H.-P.,
RA   Kalinowski J., Zotchev S.B.;
RT   "Complete genome sequence of Actinoalloteichus fjordicus DSM 46856
RT   (=GBA129-24).";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618,
CC         ECO:0000256|RuleBase:RU364053};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR   EMBL; CP016077; APU23630.1; -; Genomic_DNA.
DR   RefSeq; WP_075742858.1; NZ_CP016077.1.
DR   AlphaFoldDB; A0A1L7FFM9; -.
DR   STRING; 1612551.UA75_28295; -.
DR   KEGG; acti:UA75_28295; -.
DR   OrthoDB; 9806690at2; -.
DR   Proteomes; UP000185506; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 2.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR01073; pcrA; 1.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          28..328
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          329..640
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          576..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         49..56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   829 AA;  90151 MW;  04A2D72315F06997 CRC64;
     MNTLFELSPD ASTSAPARRA VDSAALLAGL NPQQHQAVTH QGSPLLVVAG AGSGKTRVLT
     SRIGYLLAER DVHPGQILAI TFTNKAAAEM KERVADLVGP RANLMWVSTF HSMCARLLRR
     EARTLRELLA GDDSAGTANS NFSIYDGDDA KRLITQVARD LELDPKRFPA RTLAVHISNL
     KNELIGPVEA AEQAADELQR RVAQVYAAYQ RRLHSSNALD FDDLILRSVE LLQRFPDVAG
     YYRRRFRHVM VDEYQDTNHA QYVLVRELVG AATGDQGPAV PPAELCVVGD ADQSIYAFRG
     ATIRNIVEFE RDYPDARTIM LEQNYRSTQT ILSAANAVIS RNPDRRDKRL WTDSGEGEKI
     VGYVADNEHD EAAFVAREID RLVDAGEVVN GDIAVFYRTN NQSRVFEEIF IRLGLPYRVV
     GGVRFYERRE VRDALAYLRA LANPDDAVGL RRILNTPKRG IGDRAEAVIS VYAEQQEIGF
     APALRAAAEG RVALLNSRSQ KAVAGFVALM DELRAELDAG HDVAEILEAV LERTGYRATL
     EDSDDPQDAS RLENLTELVT VAREFVAQAL AVENEAAPVS QETAEPLSTS TDADADAEDG
     PPAGSLAAFL ERVALVADSD SVPESEDGVV TLMTLHTAKG LEFPVVFCTG WEDGIFPHLR
     ALGDPAEAAE ERRLAYVGIT RARERLYLSR ALVRSAWGQP MTNPASRFLE EIPTDLIDWR
     RLAPDRSAPS VATRWGGRSG SGFGSDSAQA AVAQGGMKTT GFGGFGRGGA ANAVPMKLDV
     GDRVSHDKYG LGKVVATDGS GPRTTATIDF GTAGRVKLML IGSVPMTKL
//