ID   A0A1L7I262_9FLAO        Unreviewed;       274 AA.
AC   A0A1L7I262;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:APU67225.1};
DE            EC=4.1.3.4 {ECO:0000313|EMBL:APU67225.1};
GN   ORFNames=C723_0927 {ECO:0000313|EMBL:OSS39810.1}, GRFL_0501
GN   {ECO:0000313|EMBL:APU67225.1};
OS   Christiangramia flava JLT2011.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Christiangramia.
OX   NCBI_TaxID=1229726 {ECO:0000313|EMBL:APU67225.1, ECO:0000313|Proteomes:UP000186230};
RN   [1] {ECO:0000313|EMBL:OSS39810.1, ECO:0000313|Proteomes:UP000194120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2011 {ECO:0000313|EMBL:OSS39810.1,
RC   ECO:0000313|Proteomes:UP000194120};
RX   PubMed=24048873; DOI=10.1099/ijs.0.051987-0;
RA   Liu K., Li S., Jiao N., Tang K.;
RT   "Gramella flava sp. nov., a member of the family Flavobacteriaceae isolated
RT   from seawater.";
RL   Int. J. Syst. Evol. Microbiol. 64:165-168(2014).
RN   [2] {ECO:0000313|EMBL:APU67225.1, ECO:0000313|Proteomes:UP000186230}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2011 {ECO:0000313|EMBL:APU67225.1,
RC   ECO:0000313|Proteomes:UP000186230};
RA   Tang K.;
RT   "Multi-omics approach to identify versatile polysaccharide utilization
RT   systems of a marine flavobacterium Gramella flava.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
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DR   EMBL; CP016359; APU67225.1; -; Genomic_DNA.
DR   EMBL; AMRU01000003; OSS39810.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1L7I262; -.
DR   STRING; 1229726.GRFL_0501; -.
DR   KEGG; gfl:GRFL_0501; -.
DR   Proteomes; UP000186230; Chromosome.
DR   Proteomes; UP000194120; Unassembled WGS sequence.
DR   GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:APU67225.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186230}.
FT   DOMAIN          1..260
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   274 AA;  30534 MW;  857155BB213BBAA3 CRC64;
     MQGIREFIPT EKKVQYIQSL LRCGFDTIDF GSFVSPKAIP QMRDTAEVLS KLDLSATQSK
     LLAIVANTRG AEDASKFEEI DYLGYPFSIS ENFQMRNTHK TIAESVEVLK EILDIANNSD
     KEVVAYLSMG FGNPYGDPWN VEIVGEWTEK LAEMGVTILS LSDTVGTSTP DIIDYLFSNL
     IPKYPNVEFG AHLHTTPSKW HEKIHAAYTA GCRRFDGAIQ GFGGCPMAKD ELTGNMPSEK
     MLSYFTQAKA DTNIKMTSFE SAYNEASKIF GQYH
//