ID A0A1L7I6U4_9FLAO Unreviewed; 618 AA.
AC A0A1L7I6U4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN ORFNames=C723_2175 {ECO:0000313|EMBL:OSS38784.1}, GRFL_2593
GN {ECO:0000313|EMBL:APU69317.1};
OS Christiangramia flava JLT2011.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Christiangramia.
OX NCBI_TaxID=1229726 {ECO:0000313|EMBL:APU69317.1, ECO:0000313|Proteomes:UP000186230};
RN [1] {ECO:0000313|EMBL:OSS38784.1, ECO:0000313|Proteomes:UP000194120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2011 {ECO:0000313|EMBL:OSS38784.1,
RC ECO:0000313|Proteomes:UP000194120};
RX PubMed=24048873; DOI=10.1099/ijs.0.051987-0;
RA Liu K., Li S., Jiao N., Tang K.;
RT "Gramella flava sp. nov., a member of the family Flavobacteriaceae isolated
RT from seawater.";
RL Int. J. Syst. Evol. Microbiol. 64:165-168(2014).
RN [2] {ECO:0000313|EMBL:APU69317.1, ECO:0000313|Proteomes:UP000186230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2011 {ECO:0000313|EMBL:APU69317.1,
RC ECO:0000313|Proteomes:UP000186230};
RA Tang K.;
RT "Multi-omics approach to identify versatile polysaccharide utilization
RT systems of a marine flavobacterium Gramella flava.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
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DR EMBL; CP016359; APU69317.1; -; Genomic_DNA.
DR EMBL; AMRU01000007; OSS38784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L7I6U4; -.
DR STRING; 1229726.GRFL_2593; -.
DR KEGG; gfl:GRFL_2593; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000186230; Chromosome.
DR Proteomes; UP000194120; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810}; Reference proteome {ECO:0000313|Proteomes:UP000186230};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 372..393
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 430..456
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 532..549
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 555..574
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 95..359
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 373..571
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 70787 MW; 3D76D1A567AF9A45 CRC64;
MEEKKIDIQS IIGFILIGGI LIWMLYNNKP EEEVQDNPKD QTEQIVEKSQ QEPVQEEQAR
DSVANDSTAL VAAQKKLGAF GYSSTLSSAQ GGTTTLANDV LELKVSNKGG YIQEAKLKNF
KTYDSVPVYI IKDGNATFNL NFNTTDGRSL NTENLFFQPE LTENNGSQVL SMKLKVSENE
FLEYRYSLKP GEYMMDFSIR SQGLSGVLDA SQTPNLDWQI KGYRHAKSIS YENRYTDLVY
EYGGGDDDNI RSGDDEEENV SYIAYRQHFF TSILLTDTPF EKVNFNVTDL VEDEDVDTVY
TKNFASTIPL ELKAGELNYN MNWYYGPADY KILNDYDRNL DEVIPLGWGI FGWINKYIFI
PFFAFLSGFL PSYGLAIIAM TIVVRIVLSP VTYKSYLSQA KMKVLRPEIN EINEKYKDNA
MKKQQETMKL YSKAGASPMS GCLPALMQIP VFYALFQFFP SAFQLRQKSF LWADDLSSYD
VIAHLPFKIP FYGDHVSLFP ILAAIAIFIY MTMTTGQSMQ ANQQPGMPNM KFLMYLSPLF
MLIFFNNYAS GLSLYYFTSN LITIGIMLVI KHVIIDENKI HAKIQENKKK PRKTNRFTRK
FQEMMEQAEE QQKKQGRK
//
