ID A0A1L7I9S5_9FLAO Unreviewed; 315 AA.
AC A0A1L7I9S5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Aldehyde reductase {ECO:0000313|EMBL:OSS37574.1};
DE SubName: Full=Aldo-keto reductase family 1 member B10 {ECO:0000313|EMBL:APU70330.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:APU70330.1};
GN ORFNames=C723_3545 {ECO:0000313|EMBL:OSS37574.1}, GRFL_3606
GN {ECO:0000313|EMBL:APU70330.1};
OS Christiangramia flava JLT2011.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Christiangramia.
OX NCBI_TaxID=1229726 {ECO:0000313|EMBL:APU70330.1, ECO:0000313|Proteomes:UP000186230};
RN [1] {ECO:0000313|EMBL:OSS37574.1, ECO:0000313|Proteomes:UP000194120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2011 {ECO:0000313|EMBL:OSS37574.1,
RC ECO:0000313|Proteomes:UP000194120};
RX PubMed=24048873; DOI=10.1099/ijs.0.051987-0;
RA Liu K., Li S., Jiao N., Tang K.;
RT "Gramella flava sp. nov., a member of the family Flavobacteriaceae isolated
RT from seawater.";
RL Int. J. Syst. Evol. Microbiol. 64:165-168(2014).
RN [2] {ECO:0000313|EMBL:APU70330.1, ECO:0000313|Proteomes:UP000186230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2011 {ECO:0000313|EMBL:APU70330.1,
RC ECO:0000313|Proteomes:UP000186230};
RA Tang K.;
RT "Multi-omics approach to identify versatile polysaccharide utilization
RT systems of a marine flavobacterium Gramella flava.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP016359; APU70330.1; -; Genomic_DNA.
DR EMBL; AMRU01000021; OSS37574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L7I9S5; -.
DR STRING; 1229726.GRFL_3606; -.
DR KEGG; gfl:GRFL_3606; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000186230; Chromosome.
DR Proteomes; UP000194120; Unassembled WGS sequence.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IEA:InterPro.
DR CDD; cd19123; AKR_AKR3G1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044496; AKR3G.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:APU70330.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186230}.
FT DOMAIN 15..291
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 48
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 77
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 315 AA; 35715 MW; 11190930F29AA7F7 CRC64;
MKKLKFTNGD QMDAIGLGTW KSEKGAVTKA VKIALENGYR HIDCASTYGN EAEVGEAFKE
VFEGNTVKRD DVWVTSKLWN NAHKKEDVIP ALKNTLNDLN LEYLDLYLMH WPVAIKPEVG
FPEKAEDFLS LDEVPLIETW NEMVKAKEQG LVKHIGVSNF SIPKLKGLME ETDHTPEMNQ
VELHPYLQQN ELLEFCSRNQ INVTAYSPLG SGDRPDRMKA ADEPSLLENP VIQRIAKKHG
ANEGQILIKW SEQRGTGVIP KSTNKERIIG NLASAGFQLD EDDLKEIAEL DEHFRYVTGK
FFEMEGNSYE NIYDD
//
