ID   A0A1L7WDN5_9HELO        Unreviewed;      1203 AA.
AC   A0A1L7WDN5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Related to DUF726 domain protein {ECO:0000313|EMBL:CZR50906.1};
GN   ORFNames=PAC_00780 {ECO:0000313|EMBL:CZR50906.1};
OS   Phialocephala subalpina.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Mollisiaceae; Phialocephala;
OC   Phialocephala fortinii species complex.
OX   NCBI_TaxID=576137 {ECO:0000313|EMBL:CZR50906.1, ECO:0000313|Proteomes:UP000184330};
RN   [1] {ECO:0000313|EMBL:CZR50906.1, ECO:0000313|Proteomes:UP000184330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 11012 {ECO:0000313|EMBL:CZR50906.1,
RC   ECO:0000313|Proteomes:UP000184330};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TMCO4 family.
CC       {ECO:0000256|ARBA:ARBA00009824}.
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DR   EMBL; FJOG01000001; CZR50906.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1L7WDN5; -.
DR   OrthoDB; 8526at2759; -.
DR   Proteomes; UP000184330; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR   PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184330};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        587..612
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          987..1011
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1035..1203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          935..966
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        35..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1064..1095
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1157..1177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1182..1203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1203 AA;  132159 MW;  EFADA8439ED14485 CRC64;
     MPESGPVPVN TEKAEAVSNG DVADIPAPPA ELDDFGLPMK KHKVSSPVES DAEDEEGPQE
     GRKEVNGHTS SREEGSARNA RSQKEPQREE SSEEEEEFKD ARSTPQPATP LPVLADSEEN
     VQTNLIPAVE LPKVKETVKE IEPSKDEVVD EPANAAEPET ETKSAPESPK QDTKEGKQSQ
     GNSGVQTPKT PNGHLRGQSS TGGGVSEWSH QQWTTKPEET PKKEEDEWQV MPAYAPYDIY
     DDDNKLVAKE HDSDVEEDVY DGLGGAGKGY TRVQLDEDAQ SATSLDENTQ YLFKDVNGGT
     GAGVEDDEQR DAVSQMQATK DLLTEGQRIA YVGMTRLILS TMCKQAEDTA SAKGSKKEMK
     MAAEAMQMWS QKMMVRLYAH MEISTAEQIM IEQLSEHGVV PEDMTPTLMQ NARVKNPMAE
     ERPSTSSDVL STRTESMASS DKSPRPSISS KQSVVSPRIP QTPSTPDLYD EPPAAVPPPY
     QKHEGDDLPA VRTPNQLPTT ANLDIDLRWT VLCDLFLTLI ADSVYDARSR VLLEKVGENM
     DVSWLEICRF EKRVTDALEM QQAAEKENWN EDEHKENRRK MALKKRYVMM GLATVGGSLV
     IGLSAGLLAP VIGAGLAAGF TTIGVAGTSG FLAGAGGAAI ITSGAAASGG IIAVRAANRR
     TGAVKTFEYR PLHNNKRVNL IVTVSGWMTG KVDDVRLPYS TVDPVMGDIY SVLWEPEMLT
     SMGDTINILA TEALTQGLQQ VLGSTILISL MAALQLPVVL TKLAYLIDNP WTVSLDRANS
     AGLILADSLI DRNLGTRPIT FVGYSLGSRV IFSCLKELAR KGAYGLVQNV YLFGSPIVAK
     KEEYLKARGV VAGRFVNGFA RNDWILAYLF RLTSGGISKV AGIAPVDDIP GLENIDVTEF
     VPGHMAYRTA MPRLLREVGW LVESDEFTEI EDPDPENHQQ RQRELINEIE EARKEFEKKE
     KEKEAKGKFG FFSRKKKEVV QKKEWEMYEE HKGEPSKPKG SNVEDEEGNN HGVLFDIDAI
     RAELASEQME VRELKSTLPP MKLDLGSSSR NSLNPRESLR ETKSYEVPGS NTLKVTKSAT
     SPLPRQPSSE YIPTFKSTPR YGEEEEEEVQ MSFDTAYYSP PRSAATSSNH LPLRLNSPLP
     APPTPEPTDR AAALQRPELK SSSTLPVPGT TSTLPPLDFG HNAWADDDDE EFGKEREMEL
     SFA
//