ID A0A1L7WRQ1_9HELO Unreviewed; 847 AA.
AC A0A1L7WRQ1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Probable KEX1 protease {ECO:0000313|EMBL:CZR55454.1};
GN ORFNames=PAC_05342 {ECO:0000313|EMBL:CZR55454.1};
OS Phialocephala subalpina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Mollisiaceae; Phialocephala;
OC Phialocephala fortinii species complex.
OX NCBI_TaxID=576137 {ECO:0000313|EMBL:CZR55454.1, ECO:0000313|Proteomes:UP000184330};
RN [1] {ECO:0000313|EMBL:CZR55454.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11012 {ECO:0000313|EMBL:CZR55454.1};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; FJOG01000006; CZR55454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L7WRQ1; -.
DR STRING; 576137.A0A1L7WRQ1; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000184330; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000184330};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..847
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012656859"
FT TRANSMEM 715..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 480..615
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 641..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 194
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 232
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 404
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 847 AA; 92865 MW; FF2D6DF68D24BACE CRC64;
MRLHSVLGLI GLGYLASASN LRARNYDAQD YYVLHLDPTT PPAQVAVELG LTHEGKLGEL
EDHHIFSCHK QDDDVVHTAL KERRRRKRSI GGSDLLDGVK FAQKQKMKAR MEKRGIIPPR
PAGYAAPIEE RQTSPEDAAL IKQAAVATQL GILDPIFAEQ WHLFNTVQIG HDVNVTDVWM
QGITGHNATV AIVDDGLDMY SDDLKDNYFA EGSYDFNDNQ LEPKPQLADD RHGTRCAGEV
SAVKNNVCGV GVAWDSKIAG IRILSKLITD ADEAIAMNYA FQKNQIYSCS WGPPDDGRSM
DAPGILIKRA MLNAVQNGRG GLGSIYVFAS GNGAANEDNC NFDGYTNSIY SITVGAIDRK
GLHPYYSEKC SAQLVVTYSS GSGDAIHTTD VGTNACYSGH GGTSAAAPLA AGIFALVLQI
RPDLTWRDMQ YLVMQTALPI DIDTGEWQTT SIGRKFSHTF GYGKIDSWAT VEAAKTFKNV
KPQAWFYSPW IHVNQAIPQG DQGLAVSFEV TADMLKAANL ERLEHVTVTM NVDHTRRGDL
SVELVSPDKI ISHLAATRRL DTAPEGYDDW TFMSVVHWGE SGIGTWTIIV KDTMVNEHNG
TFVDWHLKLW GESIDASKAT LLPMPSEHDD DNHDQVISTT TIAGATTSVT PVSTPTSMMA
NPTDHPDRPT KPKPSGTTED ENTPTTSSSP AATTSASSWL PSFFPTFGGS SKKQIWIYGA
AALILVFCSA LGIYLYMARR KRLRNNPRDE WEFDLLEEDE TEGLTGGGKK GAKKGGKRRA
GELYDAFAAG SDESDTEYLD DNEGGDEREK KLYESDDEGK HVIGDDEDED EEGHNEKSHQ
GEHLLRK
//
