ID A0A1L7WVP4_9HELO Unreviewed; 351 AA.
AC A0A1L7WVP4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Glyoxylate reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PAC_06727 {ECO:0000313|EMBL:CZR56838.1};
OS Phialocephala subalpina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Mollisiaceae; Phialocephala;
OC Phialocephala fortinii species complex.
OX NCBI_TaxID=576137 {ECO:0000313|EMBL:CZR56838.1, ECO:0000313|Proteomes:UP000184330};
RN [1] {ECO:0000313|EMBL:CZR56838.1, ECO:0000313|Proteomes:UP000184330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11012 {ECO:0000313|EMBL:CZR56838.1,
RC ECO:0000313|Proteomes:UP000184330};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJOG01000009; CZR56838.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L7WVP4; -.
DR STRING; 576137.A0A1L7WVP4; -.
DR OrthoDB; 1111153at2759; -.
DR Proteomes; UP000184330; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12168; Mand_dh_like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000184330}.
FT DOMAIN 82..348
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 136..316
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 351 AA; 38967 MW; 2E13D4F9CF73642D CRC64;
MEFKPLTPLS KPTVLLVHGD TRTIRHEQWN RVQQKFNILT YDCIDADEFC KRLAPGGTYC
NINAIVRTGW RKAEPYASHF LYTAEVAKHY PPSLKLIVSS GHGHDEADMD TLTRMGIWYC
NTPDTCTEAV ANTALYLILS AYRHFTFAEY CARNDWALSR SLGMKTVDPL GSMLGIVGLG
DIGTSIARKA ALGLGMKLCY FNRRRDVERE RQVGADISYC ESLAELLKNS DCVVLACPYT
ASTHHMLSTK EFALAKEGGM RIVNIARGRL IDEAALLQAI KDERVTGVGL DVHENEPGIN
EGWSGDYMAT VLPHIGVCSK TSWDGFEKGC WDNAEAFFDT GKPLTPVNSI V
//
