ID A0A1L7X2E7_9HELO Unreviewed; 1449 AA.
AC A0A1L7X2E7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=PAC_09093 {ECO:0000313|EMBL:CZR59201.1};
OS Phialocephala subalpina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Mollisiaceae; Phialocephala;
OC Phialocephala fortinii species complex.
OX NCBI_TaxID=576137 {ECO:0000313|EMBL:CZR59201.1, ECO:0000313|Proteomes:UP000184330};
RN [1] {ECO:0000313|EMBL:CZR59201.1, ECO:0000313|Proteomes:UP000184330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11012 {ECO:0000313|EMBL:CZR59201.1,
RC ECO:0000313|Proteomes:UP000184330};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
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DR EMBL; FJOG01000013; CZR59201.1; -; Genomic_DNA.
DR STRING; 576137.A0A1L7X2E7; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000184330; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000184330}.
FT DOMAIN 31..418
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 497..664
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 712..805
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 826..1113
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1124..1316
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 737..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1400..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1440
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1449 AA; 164367 MW; 8CCAC9CFBB8A614E CRC64;
MAPTTRVKEA AKSEVEGARP TVADVEGDDG FAQLAKTHWL KKTKKTTKVK VKQDVLKNEI
WEVLEKDGFP FKSLLVLENL QILESYLWPG FSEDSSNIHI LLIVLIANVK TREHLPVWDI
FTDNSAEFSG LFRRVLSMTL DTTLSPTIRT YLLCFVITSF QSLDSGIVRK ECAPLVSISV
WHNMSTEKKR ERKLDQSVQL RKAWRAAAKR YDAADEETKP RLRFERAWLF TLVLDFLNQL
YNEKSKSENI RYCERFVEFL SDLQSQLPTR RYVNTLLQDL NILSAIRLSP AFNDEDNSLL
RDLYALLKHY TYFSIDDHTG IQHTRTEAYE KHCATLASLQ RTALKHFKEK LTILALSNYG
SIDKRSELEG HLEALTDEEV TQLCELLEFR TSYPSSTHVV ADRRFLTEVL LSGHEKRKTF
QETARDLSIL PTELTLFEPT LLRNDSYNGS EPLAIPKLNL QYLTVGDFLW RSFILHRCES
FYEIRNHVED VIKRLRPSTN RAGKTNFDGY SRMALPISKP SILEVVPPLV GSDKPSAVRA
EIALDVSRLA DNVRQEWETL RPDDVIFLLA VQGPDNSNMI TNGGEIPSDA QKIGLRYLRA
AEVTQVLDEK GRSLRDQDRQ NSYGRPRLRR LQVKIDAAVY KEDMDRVSRG KPDIYEGMNL
IVRRRGRENN FKPILESIQS LTLSDVPLAS WLHEVFLGYG DPAGATYTHL SNAIKKIDYR
DTFLDWQHLI ESLPGKTLEP SDDVEGSFGP PYVLQSAPKA EEAAPMKPSK KRRRDAEPAP
PAAAPQAVQI STYKPPNTGP YPMDAPKLNQ VRFTPTQVDA VISGTQPGLT VIVGPPGTGK
TDVATQIINN IYHNFPEQRT LLIAHSNQAL NQLFQKIVAL DIDERHLLRL GHGEEELDTE
ANFSKHGRVE SFLENRDGYL REVDRLAANF GAPGAHGASA ETAGYFNSVY VEPAWTRFEE
VSKTSDATAE AIMSSFPFHY YFSNALQPLF PPDADKDTVV DIANGCYHHV RKIFTELADV
RPFEILRRDR DKANYLLTNE ARIIAMTSTH AAMRRREIAT LGFHYDNVIM EEAAQITEIE
NFIPLALQNP KNGQMPLQRV VLCGDHFQNS PVIQNLAFRQ YANLEQSLFS RLVRLGVPTI
NLDQQGRARP SIASLYSWRY QNLGSLPVVS TAQEFITANA GFKYDYQFIG VPDYKGKGES
EPTPHFIQNL GEAEYAVAIY QYMRLLGYPA EKISILATYA GQRALIKDVL AHRCAKNPLF
GLPQIVTTVD KYQGEQNDYV ILSLTRTSRV GYLRDIRRLT VALSRARLGL YILGRRAIFE
SCFELRQAFD ILLQRPDKLQ LVTGELWPSN RILSEEEGKD VPGQTQMEGL EHLGQYVFEM
TNSKIQQLRA ERGLGELITQ DTPGVVDGNE EEEGYVDGDG YLGPEDEEEI EEEIKEGFEA
EDGPDDQKL
//
