ID A0A1L7X771_9HELO Unreviewed; 3173 AA.
AC A0A1L7X771;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Related to polyketide synthase {ECO:0000313|EMBL:CZR60866.1};
GN ORFNames=PAC_10762 {ECO:0000313|EMBL:CZR60866.1};
OS Phialocephala subalpina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Mollisiaceae; Phialocephala;
OC Phialocephala fortinii species complex.
OX NCBI_TaxID=576137 {ECO:0000313|EMBL:CZR60866.1, ECO:0000313|Proteomes:UP000184330};
RN [1] {ECO:0000313|EMBL:CZR60866.1, ECO:0000313|Proteomes:UP000184330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11012 {ECO:0000313|EMBL:CZR60866.1,
RC ECO:0000313|Proteomes:UP000184330};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; FJOG01000017; CZR60866.1; -; Genomic_DNA.
DR STRING; 576137.A0A1L7X771; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000184330; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF22; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000184330};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..431
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2483..2561
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT ACT_SITE 2897
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 3173 AA; 349640 MW; EA1C50CC5D0A45B8 CRC64;
MTNQVPIPIA VVGIGCRFPG GANSPQKLWQ MLSEGRSGWS EVPHDRWNSN SFHHPSAEAK
DGFDVHGGHF LDQDISVFEP SFFGISANEA ESMDPQQRIL LETTYEALEN AGIPQEKIRG
SDTGVYVGYF ARDYDRMVFK DTSDLPKQHI TGGGDAIVSN RISYVFDLKG PSMTIDTGCS
GSLVALHLAC QSLRAGESAM SIVGGVNLHL SPDYDVMMSF VNVLNKDGKC YAFDSRGSGY
GRGEGSATIV LKRLDEALAN GDSIRGVIRN TGINQDGKTN GISLPNKEAQ KGLIRSVYQS
SGLDPYDTGY VEAHGTGTVV GDQAEVDSIA ELFTGYGKQD DEIFVGSVKT NLGHLEAASG
LAGLIKTLLV LEKGLIPPNL NLQKEKEGLH LETRKIKVPL KLERWSKSGI RRASVNSYGY
GGTNCHAILE AVPTANVNGF KVEVASKSSN GTLSNGFHTE TVSVNGNGIL SNGFHKETVQ
INSNKSLVPV RNNTLYKITD QTSKGAQLFV LTSKSQKSLP VIAENLRRVL ASYPGDNAYL
KDLAYTLSCR RSLLQWRCCV IATNHQELVA ALDPTKLRIF KSNIDVRVFI FTGQGVQWPT
MGRDLITRYS TFRESLDTSA NILRVLGADW DLIDELTKDT SSRVNESEIS QPVTTAIQVA
LVDLLAAFNI KPQEVLGHSS GEIGAAYAAG VLSHEAALTV SYRRGFVATA CRRAVSGGGA
MLAAGIGEDE INSYIERLRA GIVCVACMNS PSSTTISGDT AAIDELHAHL DEAGIFNRKL
KVDVAYHSHH MRGFANQYLQ SIEGLVAKNP SPGVKFFSSV TGKQKVSGFG AEYWMENLVS
QVKFSIALEE LSRSQHTGAT FIEIGPHSAL QGPIRQIMTQ PNLESYKYSY FPTLLRNNDG
VRTLLDLSKH LFESGCLINL GVINSLNDSK HRYAVVKDLA PYAWDHSVKY WRESRLSKDH
RLRPHPYHDL LGLRIVSSTV NEPIWRHIIN ADRLPWLRDH VVDDSVIFPG SGYLCMAIEA
IRQITQDRRV AGTVLNYIFK DVSFRKALIV PDSPGSVEML LALTPSIKTV ADRNSTMREE
FRISSLAADG SWREHCNGLV SVEFDATNVD EVEGQRETHL SVIGEQEQLR DTEDNTPTVV
NTVAMYEDLA ANGNTYGPSF ALVKQLRLGQ HQGLATIEIP DVQAIMPSHF FQPHVIHPTT
LDALMQIEVP LFNQHCGFGA VMPVFFEDLA ISADIVNTPG SNLTAMTKVF PAGSKSLTFD
STVFQTRGDV QTAVVKLTHG ELQRIGRPAS TADQTSNLRM NYNIEWNQDV NFLTQETIQI
TPRETPENEV SPQQRMESLD RAASLYISEC LNQIGAIDPA ISKLHLLALF DWMKRYTASE
DSKLLIDNIS SSDKASLFAQ LAALGAEGEM LSRLGGNLQS ILQGKLDALS LMLDEDLLYR
VYAENMSIQR CYLHMADYLK LLSVKEPFIR VLEIGAGTGS ATVHILDVLS HEQGVWLDRY
DFTDISSGFF EKAKPKFEKY AGYMEYKTLD IENDPAKQGF EIGTYDLVIA SNVLHATSRI
DATLSNVRKL LKPGGRLILV ELTKLRPYLN ITFGTLSGWW AGVEDGRKDC PLLSLDRWDK
ALAKNSFNGV EVAVNDYKGS AQTGALIVSK ATSDLDSTIL APVEVICGSA STHLQAFAGE
LVSAFEKVGY PATAKTWPSQ VQRDVIYIVI DDGAKPLLVH PSREQFYQII TLTTSADSVL
WISAHEDAST KSNAETGLIT GLARVARTEN TEMKFVVVHI QQNIVEERDN VVSALSKLVR
STFGATPEGE KSTETEFLYR DSQLHIPRVL PNTAFDQWMD AGKEKKDMGS FHQPSRFLKL
HVETPGLLDS LVFLNDDLVQ EPIRPDEIEI ETKAHGVNFK DVYIALGQMK PAERMTGESS
GFVTRVGSDF ETKFKVGDRV CGWGSLSPFA TRSRVLGNCA YPLPDYMSFT SAASIPVVFL
TAYIGLVRIA KLQKGQVVLI HAASGGVGQA AIMIAQHIGA TIIATVGSIS KSELLSGKYG
IPKSHIFSSR LRTFKQGILR LTQGRGVDVV LNSLSGDYLH DTWAGIAPCG TFVEIGKADI
VKRNQLSMAP FDKMVIFASL DLGVMKDYRS LELASAFAEV MSLFEKGLLK PVEPINVFNI
GNIEEAFRFI QARKHRGKVV LSSGDDAMVK IMSARPPLRL KSDATFVIAG GLGDLGRRIC
HFLAQHGAKH IVTLSRRNLD AAVRRVFEEE IRAFGAEVHI LACDVNDSER VQEIASECAA
TLPLVRGIIQ AAMVLRDRAL NKMEYDEFMT AFKPKFDGTR HLRQAFQNPN LENFIMLSSV
AAILGNPGQG NYAAGCAYED ALANSQTESN THFISLNLGL VEGSDIDTPE RRAYLLAQGA
APVRMNELFS LLEYSLSSQA REDKCNQIIS RLDRDSLSQR LGKLLKFPML NHLQRATNTK
DSRATATVSM DVAGFIGAAK AAEEVNDIVS NAIVSKISSL VALEAEDISM DVTMAEFGLD
SLVAIELKNW IARNLQAQIQ TIEILDMPSI RHLATTVIER SALVTKPVQA AAAEVQLEEV
ETANTISPNT RHPLTCCRAA KEVRKLPLHG LEQILQSYLL GIRHLVTDEE YTNSVEATEE
FQQPGSPGQL LYSQLMKMKD DPAVENWMED LYLQSMYLSR RSPTALYYDI MGTFGAVTVL
HTQAERAAVI SVTAFKFKQD LGANAVSPVC LNEMPLCMDS QDWLFNATRV PLPGSDEVVK
YKDPEYDYLI VLRLGHFFKV PLTEGNRNSS IEQLRASFQS ILDLELEDCW VGILTADERD
SWATIRNKLV SLDPENEQAI RVIDGASFLI CLDHVSPATP EDRIRNFMMD RGINRWHDKS
LQFLIASNAS TGFIGDHTKL DGGSVHQLLG SIKKAIFTYE PTGSACDNSP SLFEEVVFKT
SPDIEFEIRR MRKTWLDQCA DIDYANLEYT GFGATYLKDR RCNPQSGFEV VAQLASRMIF
GRFEACWQPV NMAHYHKGRT EIIQTMTSTM SSFITSALAS PPPRPDPALK TLFFAATREH
STSMALAQKG HGYHRTLTAM EMLAKQQGGK IPSLYSDLAW CKTGPENIMT GPRDGLFTEV
ASVWPKRESL FVNYEVGDDR ARFSVVGHGG RAHEYCKLLE KAAGIVKSIL DEE
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