ID A0A1L8CQC9_9PROT Unreviewed; 893 AA.
AC A0A1L8CQC9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Assimilatory nitrate reductase catalytic subunit {ECO:0000313|EMBL:GAV21132.1};
DE EC=1.7.99.4 {ECO:0000313|EMBL:GAV21132.1};
GN ORFNames=MMIC_P2112 {ECO:0000313|EMBL:GAV21132.1};
OS Mariprofundus micogutta.
OC Bacteria; Pseudomonadota; Zetaproteobacteria; Mariprofundales;
OC Mariprofundaceae; Mariprofundus.
OX NCBI_TaxID=1921010 {ECO:0000313|EMBL:GAV21132.1, ECO:0000313|Proteomes:UP000231632};
RN [1] {ECO:0000313|EMBL:GAV21132.1, ECO:0000313|Proteomes:UP000231632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ET2 {ECO:0000313|EMBL:GAV21132.1,
RC ECO:0000313|Proteomes:UP000231632};
RX PubMed=27766355; DOI=10.1007/s00203-016-1307-4;
RA Makita H., Tanaka E., Mitsunobu S., Miyazaki M., Nunoura T., Uematsu K.,
RA Takaki Y., Nishi S., Shimamura S., Takai K.;
RT "Mariprofundus micogutta sp. nov., a novel iron-oxidizing
RT zetaproteobacterium isolated from a deep-sea hydrothermal field at the
RT Bayonnaise knoll of the Izu-Ogasawara arc, and a description of
RT Mariprofundales ord. nov. and Zetaproteobacteria classis nov.";
RL Arch. Microbiol. 199:335-346(2017).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV21132.1}.
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DR EMBL; BDFD01000021; GAV21132.1; -; Genomic_DNA.
DR RefSeq; WP_072660436.1; NZ_BDFD01000021.1.
DR AlphaFoldDB; A0A1L8CQC9; -.
DR STRING; 1921010.MMIC_P2112; -.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000231632; Unassembled WGS sequence.
DR GO; GO:1990204; C:oxidoreductase complex; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0008940; F:nitrate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0045333; P:cellular respiration; IEA:UniProt.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04324; Fer2_BFD; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:GAV21132.1}.
FT DOMAIN 2..58
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 893 AA; 98245 MW; 2269BE7F469A0AB1 CRC64;
MTRTVNSVCS YCGTGCGIKL ESDEKRIISL IGDTRHPTNQ GKLCSKGREL HHTVRTDDRL
LRPQLRTSLD APFAPVDWDT ALDYGAQQFA DIIREHGPEA VAFYVSGQLL TEDYYAFNKL
MKGFIGTNNI DTNSRLCMSS AVAGYKRAFG ADGPPTCYAD IELAEHFFII GGNPAYAHPI
VFRRLEAAKE ANPDLKVVVA DPRRTDTCSI ADLHLPLRPG TDVALMQAML NVLIWENVID
RDYITQNTQG YETLAESVRS MTPRKAAEIC GLNAADIVQA ALWFAENRTL SFWCQGMNQS
TSGTDNGNAL TNLHLATGQV GKPGCGPFSL TGQSNAMGGR EVGGMANMLA AHRDYANPTH
REEVATYWGV DQISDKPGLT ATELFASLES GEVKAVWIAC TNPVVSMPDA KRIESGLKKA
ELVMVSDAYH PTDTTRFAHV LFPASGWAEK EGSVTNSERC ISHLEQALPA AGMSRPDWKI
TADFATALGQ KLGKNWQSSF AWEKAEDLFN EHRGLTRGMD LDITGLSYAI LDEHGPQQWP
YPEGSIPRVA KRLYENGLFE TPDNKARFVD MTFIPVAEPV NEEYPLSLTT GRIRDQWHTM
TKTGNVPALM QHYAIPQLQI HPDDAALYKL EEDDLVRIIS RRGEVIAPAR ISKDIRKGLV
FLPMHWGEMT AKGGRTNSLT KTAIDPVSKQ PEFKHAAVQL ESFNPVWRGM MLIAGEKMQL
GRIMIEGYTY GVSSCAGSDH PVTAVELACS KTLKAEQYKR LDHLLEQGQS FETLTYSDRK
HGINRKAWLQ DGHLIAVRWV GGDIAEAQWL RKLMLEGRDV GELRPYLLAP GGPVTKEDTK
GRIICACQNV GELELKDAIK KGADSIDALK ACTMAGTGCG SCIPELKGLL SGP
//
