ID A0A1L8ELK7_XENLA Unreviewed; 437 AA.
AC A0A1L8ELK7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Histamine H3 receptor {ECO:0000313|RefSeq:XP_018093706.1};
GN Name=hrh3.S {ECO:0000313|RefSeq:XP_018093706.1,
GN ECO:0000313|Xenbase:XB-GENE-17343139};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018093706.1};
RN [1] {ECO:0000313|RefSeq:XP_018093706.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018093706.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018093706.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_018093706.1; XM_018238217.2.
DR AlphaFoldDB; A0A1L8ELK7; -.
DR SMR; A0A1L8ELK7; -.
DR STRING; 8355.A0A1L8ELK7; -.
DR PaxDb; 8355-A0A1L8ELK7; -.
DR GeneID; 108702622; -.
DR KEGG; xla:108702622; -.
DR AGR; Xenbase:XB-GENE-17343139; -.
DR CTD; 108702622; -.
DR Xenbase; XB-GENE-17343139; hrh3.S.
DR OMA; DIFHEVH; -.
DR OrthoDB; 5405331at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004969; F:histamine receptor activity; IEA:InterPro.
DR CDD; cd15296; 7tmA_Histamine_H3R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR041998; 7tmA_HRH3.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003980; Histamine_H3_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF194; HISTAMINE H3 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01471; HISTAMINEH3R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_018093706.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 49..404
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 437 AA; 49906 MW; 201FD0174D14FBDE CRC64;
MDSTQQNGQQ LNDTWRSSGG DNVPGVPDFS WTVFLAVLMG VLIVSTVLGN ALVMLAFVVD
SSLRTQNNFF LLNLAISDFF VGALCIPLYV PYVLTGRWSF GRSVCKLWLV LDYLLCTSSV
FNIVLISYDR FISVTRAVSY RAQQSNSRHA VLKMTMVWIL AFLLYGPAII IWEYIAGGSI
IPDGECFAEF FYNWYFLITA STLEFFTPFI SVTYFNVSIY MNIQKRTKAR LDLLQEVQSH
MTTDDIRVPP EKARSSSLKC WKLHQKMTRF GGSNQKKTIK ITESEMIERV RGMKRNSLNG
STVTTMGKSR SARRSFNESS STPSLEKKMR VVSQGIAQRF RLSRDKKVAK SLAVIVCVFG
LCWAPYTLLM IIRAACRGHC VPNYWYEASF WLLWVNSAVN PILYPLCHNS FKRAFKKILC
PQKLKLKANG KFHYCWK
//
