UniProt: A0A1L8EMK6

Database: UniProt
Entry: A0A1L8EMK6_XENLA

LinkDB:  A0A1L8EMK6_XENLA 
Original site:  A0A1L8EMK6_XENLA

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (15)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (3)   
   SMART (1)   
All databases (22)   

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ID   A0A1L8EMK6_XENLA        Unreviewed;      1943 AA.
AC   A0A1L8EMK6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Myosin-7B {ECO:0000313|RefSeq:XP_018093911.1};
GN   Name=myh7b.S {ECO:0000313|RefSeq:XP_018093911.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018093911.1};
RN   [1] {ECO:0000313|RefSeq:XP_018093911.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018093911.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018093911.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC       ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   RefSeq; XP_018093911.1; XM_018238422.2.
DR   STRING; 8355.A0A1L8EMK6; -.
DR   PaxDb; 8355-A0A1L8EMK6; -.
DR   GeneID; 108702765; -.
DR   KEGG; xla:108702765; -.
DR   AGR; Xenbase:XB-GENE-11536246; -.
DR   CTD; 108702765; -.
DR   OMA; ITMLQAF; -.
DR   OrthoDB; 2877572at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 108702765; Expressed in heart and 4 other cell types or tissues.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd14927; MYSc_Myh7b; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.340; -; 3.
DR   Gene3D; 1.20.5.370; -; 5.
DR   Gene3D; 1.20.5.4820; -; 1.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 6.10.250.2420; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR004009; Myosin_N.
DR   InterPro; IPR008989; Myosin_S1_N.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR   PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF02736; Myosin_N; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 5.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51844; SH3_LIKE; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT   REGION          664..686
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   REGION          1913..1943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          851..1165
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ   SEQUENCE   1943 AA;  223955 MW;  4A140813EA8AE2AF CRC64;
     MSSLLDMTEF GEAADYLRKS DRELMKLQTI PFDGKKKAWI PDDKEAYIEV EIKDSSGGNV
     NVETKDKKTL SVKEDDIQQM NPPKFDMIED MAMLTHLNEA SVLDNLKRRY ANWMIYTYSG
     LFCVTVNPYK WLPVYTATVV AAYKGKRRSE APPHIYSIAD NAYNDMVRNR ENQSMLITGE
     SGAGKTVNTK RVIQYFAIVA ALGEGFGKKS QAPATKTGGT LEDQIIEANP AMEAFGNAKT
     LRNDNSSRFG KFIRIHFGPT GKLASADIDI YLLEKSRVIF QQPGERSYHI YYQILSGKKP
     ELQDMLLVST NPYDYHVCSQ GVTTVDNLDD GEELMATDHA MDILGFSQEE KTGSYKIVGA
     VMQFGNMKFK QKQREEQAEA DGTESADKAA YLMGISSADL IKGLLHPRVK VGNEYVTKGQ
     NVEQVVYAVG ALAKATYDRM FKWLVSRINK TLDTKLARQF FIGVLDIAGF EIFEYNSFEQ
     LCINFTNEKL QQFFNHHMFV LEQEEYKKEG IEWVFIDFGL DLQPCIDLIE KPMGILSILE
     EECMFPKASD MSFKAKLYDN HLGKSPNFQK PKLDKKRRYE PHFELMHYAG VVPYNIMGWL
     DKNKDPLNET VVTVFQKSSN KLLASLYENY ISSYSVEHQK PGVKEKRKKA ASFQTVSQLH
     KENLNKLMTN LRSTQPHFVR CIIPNESKTP GVMDPFMVLH QLRCNGVLEG IRICRKGYPN
     RLLYADFKQR YRILNPNAIP DDKFVDSRKA TEKLLGSLDI DHTQYKFGHT KVFFKAGLLG
     QLEEMRDERL AKIITMLQAR SRGRLMRIEY HKIIARRYAL MVIQWNIRAF NAVKHWSWMK
     LFFKIKPLLK SAQTEKEMAN MKEEFLKLKE ALEKSEAKRK ELEEKQVTLI QEKNDLGLQL
     QAEQDNLADA EERCDLLIKT KIQLEAKVKE LTERLEDEEE MNSDLTSKKR KLEDECAELK
     KDIDDLEITL AKVEKEKHAT ENKVKNLIEE MAALDEIIAR LTKEKKALQE AHQQALDDLQ
     AEEDKVNTLT KAKAKLEQQV DDLEGSLEQE KKLRMDLERS KRKLEGDLKL TQESVMDLEN
     DKQQLEEKLK KKDFETSQLN SRIEDEQMMC AQLQKKIKEL QARIEELEEE LEAERATRAK
     VEKQRAEVAK ELEELSERLE EAGGATSVQI EMNKKREAEF LKLRRDLEEA TLHHEATAAG
     LRKKHADTVA ELGEQIDSLQ RVKQKLEKEK SEMKMELDDF TSNIEQLTKN KANAEKLCRT
     FEDQLSEAKC KVDELQRQLA DISLHRARLQ TENGELSRLL EEKESFVNQL SRGKASFTQS
     IEELKRQLEE ETKAKNALAH ALQASRHDCD LMREQYEEEQ EAKGELQRSL SKANAEVAQW
     RNKYETDAIQ RTEELEEAKK KLAARLQDAE QAVETANAKC SSLEKTKHRL QTEIEDLVID
     LERANSAAAA LDKKQRNFDR ILGEWKQKYE ETQAELEASQ KESRSLSTEL FKLKNAYEES
     LDNLETMKRE NKNLQEEIAD LTDQISASGK MIHELEKVKK ALESEKSDIQ AALEEAEGAL
     EHEESKTLRI QLELSQIKAD VDRKVAEKDE EIENLRRNHQ RAMESMQASL DAEAKARNEA
     IRLKKKMEGD LNEMEIQLNH ANRQAAESQK MVRNLQSHVK DLQIELDDTL RHNDDLKEQA
     AALERRNSLL LAEVEELRAA LEQAERGRKL AEQELLEATE RVNLLHSQNT GLINQKKKLD
     ADISQLTTEV EESVQECSNA EEKAKKAITD AAMMAEELKK EQDTTAHLER MKKNMDQTIK
     DLQMRLDEAE QIALKGGKKQ IQKLEAKVRE MEGELENEQK KNAETQKGIR KYERRIKELT
     YQTEEDRKNL ARMQDLIDKL QMKVKSYKRQ SEEAETQANS NLLKYRKIQH ELDDAEERAD
     VAEGQVNKLR ARTREAASSK HEE
//

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